Well just a few months ago my Alp was up. I had broke my finger and we thought that caused it. That was the beginning of June. Now it's Oct. and my finger is healed and my last two blood tests all of it's high. My Alp is high and so is my Ast and Alt. My ALT used to be around 52, a lil high and the other two were more normal. Now Alp is 163 normal range is 44-121. Alt is 153 range 0-32 and Ast is 77 range is 0-40. My Ama M2 is still positive but not as high as it was 7-8 years ago at 68. It's 29.1 about 5 point over equivocal. I'm also taking new meds metformin and doxycycline and linzess every few days. I wonder if they in some way had anything to do with it. My Alp went down in Sep. to 130 and then back up again on the next test. The Dr said he was going to start me on Urso if still positive after hepatic panel that he wanted me to do in the first week of Nov. Does pbc present this way with the other lft's increasing dramatically too?
Lfts are still up: Well just a few months... - PBC Foundation
Lfts are still up
Have you joined the PBC Foundation they have some very good information for the patient and practitioner who may refer you to a gastroenterologist or hepatologist . The following link gives information in leaflet form which is free to download.
pbcfoundation.org.uk/health...
I probably did. I'm not sure. But thank you for the link.
Not sure why they have waited 6 or 8 years to start you on urso. I was started right away by the specialist and my liver panel had remained normal until just recently. In the past two years, my ALP has been somewhat elevated and I am not sure why, but my GP doesn't seem concerned. It went up after two new things - 1000 mcgm daily of B12 and my 4 COVID shots. Don't know if there is any connection. I have had PBC for about 15 years, perhaps the disease is progressing.
I am due for liver panel tests now.
"AMA-M2 is detected in 90-95% of patients with PBC"
Best wishes.
They did the biopsy years ago and my Alp was normal then. The biopsy only showed mild fatty liver at the time. So he blamed the elevated alt and ast liver enzymes on that. My mom has a fatty liver and in her 70's, it actually stated it on her CT scan that she had fatty hepatic degeneration. Her numbers though look great. I had always felt that I probably had it still.
Happy with first follow up labs
Sudden rise in ALP 
Which blood work and/or criteria was used to diagnose your PBC?
Lab Values and Fibrosis 
Experience with LFT's going up and down??
