I'm pretty sure there are 3 indicators for PBC and you need 2 of the 3 to be diagnosed. If this is wrong, I'm sure someone more knowledgeable will be along shortly. One indicator is the AMA. One has to do with elevated LET. The third one is that it shows on a biopsy. I believe that is correct. You can search on here for more information though. I just did not want you to go a long time with no response.
AMAs alone are not enough to formally / officially diagnose PBC.
The presence of AMAs (sub-type M2) are one of the indicators of PBC, but more relevant positive tests are needed for a formal diagnosis, as some people just 'have' AMAs.
(I do, have had since they were noted in 1992, and I don't have PBC - as confirmed by one of the UK's leading PBC consultants, after a local liver chap had tried to suggest I had PBC. Apart from getting a bit older and odd normal general issues, I am in good health and don't have PBC.)
If they have checked your liver function tests, and they are fine, then you could ask for a biopsy. This is the third line of diagnosis for PBC (usually people are diagnosed with PBC because of AMAs and abnormal liver functions tests (lfts) that are typical of PBC - it has to be both. AMAs alone are not enough and if lfts were abnormal they would probably do a biopsy.
However, they should be ruling out all other possible autoimmune conditions, especially those related to the other subtypes of AMA, and also checking for all liver conditions, and doing full blood panels to check that everything has been covered.
I hope this helps, but do talk to the advisors at the 'PBC Foundation' (link at top of page), as they will be able to help and direct you to their recent publication about the official guidelines for the diagnosis of PBC.
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