It's been so great to read your posts, it does make you feel you are not alone in this. I have just been diagnosed today and given URSO. As I am both ANA and AMA positive, the doctor thinks that I should do a liver biopsy as well to rule out overlap of both PBC and autoimmune hepatitis. I am very scared about that. I guess I have had PBC for quite a while as I've had elevated liver enzymes for some years but the doctors never suspected it. They just asked about my drinking habits (don't drink at all) and sent me to have hepatitis B and C tested which came out negative and then just shrugged their shoulders. Luckily I've been reading a lot about my symptoms (itchy skin, achy joints, fatigue and irritability) and came across PBC and then I had the tests done and they came out positive. I hope it is not too bad as we have just adopted a little boy and it would be my worst nightmare to cause him any pain. I am so worried that the disease might progress rapidly and he will yet again have to face loss after being abandoned by birth mom. My alkaline phosphatase and GGT were around 250. Is that very bad? I also asked the doctor about liver transplants if the condition gets really bad but she said there are very few performed each year (I live in Eastern Europe) so the likelihood of that is almost nil. Oh, and another question, do any of you have low-grade fever now and then associated with aching joints? Thank you for being there! Hugs to you all!