Hello all. I am 46 and female. I was just diagnosed with pbc. My ama level is 2.3. My biopsy shows inflammation in liver but no scarring yet so... (early stage). My alkaline phosphatate is 350. My alt is 126 and my ast is 117. I had a positive Ana also but low titer. My doctor thinks I may also have autoimmune hepatitis. I am tired in the afternoons. I have had itchy legs for years but better lately with steroid cream and I'm careful not to use shaving cream and lotions. Only unscented dove soap and creams. I will be starting on the urso and nervous about side effects. I have gained 10 to 15 pounds in the last few months. I don't know if it's pbc related. Any advice would be great.