When I was first prescribed URSO in December 2010 I was told to take two tablets in the day and two at night. I noticed on the leaflet that came with my latest lot of tablets that they recommend you take all four at night.
My last appointment with a hospital consultant was cancelled due to his illness and I am still waiting for a re-appointment so I haven't got anybody to ask but yourselves. My old doctor, who had some knowledge of PBC, left the practice and my new doctor, although he is very keen to learn more, does not know anything of PBC at the moment.
The thing is, since I have been following the advice of the leaflet and taking four tablets at night I have found great trouble sleeping, tossing and turning until 3 and 4 in the morning (I haven't had the itch yet so it has nothing to do with that). I don't know if this has anything to do with my taking four tablets or whether it is a pure coincidence. Has anybody else experienced this?