1.5mg methylcobalamin, 1.5mg adenosylcobalamin, 1mg hydroxocobalamin. SC injection 5 times a day including setting an alarm to inject at night. 50 mg B6 in the form of P-5-P or pain from peripheral neuropathy returns.
Results of this trial are positive. Much closer to knowing what is most effective, even oral works.
I made an error in design and kept the amount of B12 the same and added hydroxocobalamin. To get valuable results I should have kept the same amount of the two forms I was injecting and added hydroxocobalamin. I corrected after a few days.
I get results in a few days now that I am not under supplementing as I was before. When making a change I experience a uptick for a few days then a downturn as my body heals with the more effective treatment. Then I experience healing. Then I design and implement a new trial.
The last trial required 25 injections a day due to my keeping the concentration of B12 at 1mg/ml constant to minimize variables.
I am now doing a trial of more concentrated B12 and not diluting as I have been. No need to design a new trial until I have established the effect of a higher concentration.
That being said I expect that my next trial will be adenosylcobalamin exclusively. As far as I know it is the least stable of the forms of B12 which is why it is not readily available (Not profitable). Rationally it makes sense that the least stable might be the most effective.
This would be a racial trial and I would have to guess what the overlap effect is having injected other forms recently. It will be the last trial with regards to form as I have experience with all forms and combinations. There are other forms than the big four and at sometime I will do what it takes to try and procure them. One is aquacobalamin I have to find the list of the other forms.
Although I have a regiment that ‘works’ that I will be able to go back to I do have trepidation when trying a new trial and those that are not positive take a lot out of me.
My methodology requires tenacity to discover and explore. I am much closer to being able to design when what is required is discipline. Looking forward to that day.
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There is no medical evidence that cold water therapy has an effect. Meaning there are no blood tests. I have used it effectively for 58 years to mitigate my transcobalamin issues.
The power went out and I had no heat and got very cold. (10% of my state was without power. It happens and we are used to it.)
That being cold and then getting warm was good for my neurological system as it has been for my whole life. A very valuable understanding as I move forward. It, like nutrition is not at all a solve for my B12 deficiency. The knowledge will be an asset going forward. It is a matter of degree being cold for long periods is not healing. My body can get to where it is too weak to get warm.
B12 deficiency is the most boring subject of exploration and discovery I have ever undertaken. Being less mediocre seems to be the standard for successful treatment.
That being said, it has only been 6 months since I reviewed the rational used for frequency and amount and found it to be pseudoscience.
Can you take too many sublinguals? 
MCV 95.3 fL and MCH level 32.2 pg (27-32) but gp refusing trial of b12 injections
I'm new here - does anyone else take sublingual B12 tablets as a treatment for PA?
