Current Trial (7 Days); 1.5mg methylcobalamin 3mg/ml, 1.5mg adenosylcobalamin 3mg/ml, 1mg hydroxocobalamin 1mg/ml. SC injection 5-6 times a day including setting an alarm to inject at night if warranted. 50 mg B6 in the form of P-5-P three times a day or pain from peripheral neuropathy returns. Benfotiamin B1 300 mg three times a day.
The major change in my current trial is the addition of B1 in the form of Benfotiamine it caused the most dramatic improvement since I started B6 3+- years ago. It has improved how I experience life dramatically where the B6 was about relief from the pain of peripheral neuropathy. I have not experienced debilitating fatigue for 7 months, since discovering the effective duration of B12 is somewhere between 3 and 6 hours. I was using the term fading and brain haze. They are both all but eliminated as is my stuffy head.
My challenge right now is to adjust to the improvement. Had any expert come up with my current trial I would likely never have gone any further and called this good enough. Another way to express the effectiveness is that I am somewhat on par with a year prior to my being in the hospital 4 weeks from death.
I will keep going with my exploration and discovery and my methodology makes it relatively easy to do that work.
So this is what happened. I read pjmhsonline.com/2013/july_s...
It is research about peripheral neuropathy that diabetics experience. It used testing designed by study. Unlike what is called research of B12 which is nothing more than reviewing past studies online and forming a personal opinion. Not leading to any change in treatment.
As I was already supplementing B6 it was a matter of adding B1 and this study even used amounts of supplements. What a concept!
B6 and B1 are not unlike B12 in that the rational approach is to do the testing which is not conclusive and then do a trial.
I did a trial of B1 for 5 days went though symptoms reappeared although not as debilitating. Decided to stop and return to my work with B12. On the second day of stopping that trial I happened to drive 1.5 hours to the ocean. The third day it seemed to me that I was more tired and took the opportunity to recreate the day before. Not often I have a chance to evaluate by repeating that closely.
Sure enough I was more tired the next trip and it was reasonable to assume it was the result of stopping the Benfotiamine. I restarted the Benfotiamine and sure enough I experienced more energy throughout the day. I have come to understand it was not more energy rather less brain haze.
I am pleased and angry this possibility is unknown by all experts.
So now I have to do a major redesign based on this information. The choices I have come up with so far are read what is thought to be true about the ‘cofactors and make rational choices with each one or go with “Simple Spectrum” which although designed for those with autism it is the best substitute for a B complex I have found although I will recheck my notes from last winter which includes an analysis of ANRC. I found the Simple Spectrum to be effective but stopped once I came to understand the flaws in the understanding of B12 treatment. (It does contain Thiamine B1.
I also need to design a new way to evaluate what I am experiencing now. I am leaning towards how I feel when I wake up and how I feel about going to sleep at night.
I may just go with performance for the summer. How much further can I hike and swim. That would be the most desirable although has the risk of me pushing and simply accomplishing.
I have some pondering to do and that is my highest level of analysis. It is also possible I am at the level of understanding and knowledge where I can only work on designing and evaluating once a week. I have done that with other study.
Note: My pee turned reddish for the first time in 3+ years of injecting B12 and the only major change was adding the B1. Interesting.
As always I appreciate that I am allowed to post here. I can not not really contribute to general discussions as my replies would always read like the old man on the porch. "Well back in the days I ...."
I am more about seeing what I do as treating my neurological system rather than B12 deficiency as I have not been B12 deficient for while and treating with B12 is only a small part of how I heal. Supplementing is really adjunctive to how I heal.
High B6
Peripheral neuropathy
B6 injections anyone
