My body did not get the memo.

[WIZARD6787]

I accept that a test had been done measuring the amount of Hydroxocobalamin and Cynocabalamin that can be measured in the urine at different times after the injection and that the numbers are likely repeatable.

I do not know if any testing was done on a subject that was B12 deficient. I find it unlikely.

I also expect that the urine test was measuring total cobalamin without regards to what form it was.

I am confident that what is known to happen when any form of cobalamin is injected with regards to the 25 processes that my body utilizes cobalamin for is not at this time understood although there is much information.

I do not find that treatment of 1mg hydroxocobalamin EOD adequate to treat my body based on the fact that my body responds favorably to more frequent injections and a higher dose than 1 mg every 48 hours. (There is no blood test that can indicate the efficacy of any amount or form of cobalamin which is all that matters to me.)

So my body did not get the memo that it is supposed to pee out any more than 1 mg EOD.

[Wheat]

I agree. I am not that interested in rules, only what is right for me. Although I do research carefully.

After loading doses I am only a few months into self treatment, I was hoping 1 ml hydrocobalamin ED s.i. would be enough and that after an unspecified period i could reduce to EOD.

No, I m finding my body needs more: currently 2 si ED plus sublingual drops, up to 3 times per day. My brain/body knows what it needs and it tells me, I listen and respond.

[WIZARD6787 in reply to Wheat]

Good on you! You are well ahead of the curve! Being honest I am jealous of the speed you got to where you are.

I like rules only when they are effective. Following rules is easy just often ineffective.

It does seem to be proved the loading then maintenance concept is not applicable to a lot of people's bodies. That concept is often applied when not applicable.

[Wheat in reply to WIZARD6787]

Thanks for your reply. I do not and cannot expect to achieve your level of physical activity, but I will be the best I can be. Time fo me is relatively short and quality of life important. I appreciate your posts as informative and helpful.

[WIZARD6787 in reply to Wheat]

I am glad you find my posts helpful and informative. It is the result of my expressing, questioning and sharing. I am not at all evangelical or instructive.

Your comment about quality of life resonated with me. That morning I had taken a stroll around a pond at the base of a mountain which I have climbed over a 100 times starting in 1972.

That stroll had as much meaning to me as the times I climbed the mountain.

Journey on!

[Bellabab]

B12 works hand in hand with folate and heavy doses of B12 will therfore use up a lot of folate. I suspect you are deficient in folate and would benefit from 5mg folic acid a day. Best to talk this over with GP. No evidence that this dose of folate is dangerous BTW.