I have been caring for my wife full time for several years now. We are both in our mid 70's and we have been together since our mid teens.
Her illness started with weight loss, anxiety and paranoia which was very out of character. The anxiety and paranoia became very serious and extreme, including at times verbal abuse that I can only describe as violent. Really horrendous.
I quickly realised that something was wrong and suspected at the time that it was related to nutrition, despite her eating good, natural food with lots of fruit and veg, salads etc. her illness became more severe. This developed into numbness in her hands legs and feet and 'pins and needles', often unable to feel her legs. Researching these symptoms I soon discovered that vitamin B12 malabsorbtion could be the cause of the symptoms.
Her symptoms continued to worsen, she became totally exhausted, lost her sense of balance, developed a shuffling gait, had pains in her joints (especially her arms), developed severe tremors in her arms and legs, in addition to what can best be described as a 'brain fog'. She also suffered from long spells of constipation followed by diarrhoea and many of the symptoms listed in the book 'Could It Be B12' by Sally Pacholok.
Private blood tests showed macrocytosis. A methylation profile (MTHFR) showed homozygous mutations referring to a difficulty absorbing B12 which was likely to have been present from birth.
After a difficult couple of years my wife is now unable to walk unaided. We have found that methyl cobalamin injections can be of help. (She is currently using 5mg every other day) along with transdermal B12 patches. I feel that because of the severity of her neurological symptoms she would benefit from increasing the amount and frequency and would like to hear from people about their experiences when increasing the frequency of the injections and also what dosages they use?