Hydroxocobalamin or methylcobalamin

[toph]

I have been injecting hydroxocobalamin and taking hydrocortisone. I'm feeling really good. I've read that methylcobalamin is better to inject than hydroxocobalamin. Has anyone any experience of injecting methylcobalamin as I might swap to it. It is more expensive than hydroxocobalamin x6 or 7 times. Is it worth changing???????

[fbirder]

No, it's almost certainly not worth switching.

Methylcobalamin is less stable and more expensive than hydroxocobalamin. Some people think it's better because it doesn't need to be converted before it can be used by the body. What these people don't take into account is...

1. There are to forms of B12 required by the body. Methylcobalamin is one, but adenosylcobalamin, the other, is just ignored.

2. Even methylcobalamin needs to be converted to methylcobalamin once it gets in the cell. With all forms of B12 the first thing that happens when it gets into the cell is that the top ligand (methyl, hydroxo, cyano or adenosyl) gets removed. The remaining part then gets shipped to where it's needed in the body where it's converted to methylcobalamin or adenosylcobalamin.

ncbi.nlm.nih.gov/pmc/articl...

That might seem a daft thing to do. But it's a lot easier than the alternative - check each B12 molecule as it comes in, send the methylcobalamin to the right place and the adenosylcobalamin to its destination and remove the top ligand from anything else.