Methylcobalamin vs hydroxocobalamin - Pernicious Anaemi...

Pernicious Anaemia Society

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Methylcobalamin vs hydroxocobalamin

toph
toph

Apparently methylcobalamin is better to take than hydroxocobalamin. Is this true.? I have been taking hydroxocobalamin 1mg per 1ml with a strong folate capsule. Methylcobalamin injections dont need the folate apparently? Methylcobalamin comes in 5mg/ml ampules so do you just take 0.2ml. Why dont you inject more than 1mg surely this would speed recovery!

7 Replies
oldestnewest

No it’s not true. Hydroxocobalamin is easier to obtain, cheaper and more stable than methylcobalamin. It’s also as, if not more, effective. ncbi.nlm.nih.gov/pubmed/258...

When any form of B12 enters the cell then the top ligand (hydroxo, cyano, methyl or adenosyl) is removed to form cobal(II)amin. That then goes to the part of the cell where it’s needed.

For the reaction to convert homocysteine to methionine the cobal(II)amin binds to the methionine synthase enzyme. Then a molecule of methylfolate binds to the same enzyme, as does a molecule of homocysteine. The methylfolate passes a methylgroup to the cobal(II)amin which then passes it on to the hCys, converting it to methionine.

So methylcobalamin is formed for just an instant.

Any methylcobalamin floating around in the cell couldn’t bind to the enzyme, so would be pretty useless.

Gambit62
Gambit62Administrator

some people respond well to methyl - some respond badly - some people don't respond at all.

It isn't clear who will respond and how - possible that genetics and environmental/life-style factors are involved but how isn't understood yet.

The only way to know which type you respond best to is to try and see - there are lots of downsides to methyl as listed by fbirder.

Personally I use a mix of all 4 types of B12 - hydroxo/cyano as injections, hydrox/methyl as nasal spray and adenosyl as sublinguals. Methyl does nothing for my mood if taken alone and I just get rattier and rattier. adenosyl seems to work well with incontinence issues - but those are just my responses.

jarlethblue
jarlethblue in reply to Gambit62

may I ask please where you source your nasal spray from and do you find it good? thanks so much. J

Gambit62
Gambit62Administrator in reply to jarlethblue

I source from a company called detox people. they do a range of sprays and also 'drops'

it works for me but no guarantee will work for anyone else

jarlethblue
jarlethblue in reply to Gambit62

thanks so much. J

jarlethblue
jarlethblue in reply to Gambit62

last question i promise...where do you get your adenosyl as sublinguals from? thanks again. J

Gambit62
Gambit62Administrator in reply to jarlethblue

same place

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