Pernicious Anaemia Society
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Test results

I have previously posted about other results and symptoms. I have paid for a medicheck Thyroid check ultra and have an appointment with my GP on the 11th October. He has been very thorough and I have been referred to a gastro, am awaiting endoscopy and MRI of intestine, and have seen a urologist for the blood in my urine.

My concerns are with the TSH increasing and B12 decreasing. Tests in July intrinsic factor antibodies and coeliac both came back negative, I went Gluten free the day after these tests were taken. I have taken the nice guidelines with previous results and have hit a wall as previous B12 was in range.

Can the low B12 cause the TSH to increase? Any advice is greatly appreciated. (I have also posted this in the Thyroid forum)

Result from sample taken 29/9/17

THYROID STIMULATING HORMONE 3.06 mIU/L 0.27 -4.20

FREE THYROXINE 13.2 pmol/L 12.00 -22.00

TOTAL THYROXINE(T4) 93.3 nmol/L 59.00 -154.00

FREE T3 5 pmol/L 3.10 -6.80

THYROGLOBULIN ANTIBODY <10 IU/mL 0.00 -115.00

THYROID PEROXIDASE ANTIBODIES 9.72 IU/mL 0.00 -34.00

VITAMIN B12 *83 pmol/L 140.00 -724.00

FOLATE (SERUM) New sample required

Inflammation MarkerCRP -HIGH SENSITIVITY *5.3 mg/l 0.00 -5.00

Iron StatusFERRITIN New sample required

Previous results from July '17

Serum TSH 2.257 mU/L (0.34-5.60) [was 1.46 in Feb '16]

Serum free T4 10.2 pmol/L ( 8-18) [was 9.8 in Feb '16]

Serum creating kinase 181 iU/L (35-160)

Serum b12 165 ng/L (>140) [was 147 on 19 June '17, I started supplementing end of may, so results are possibly higher due to this]

Serum folate 5.4 ug/L (>4)

Serum ferritin 41 ug/L (11-200)

Serum Potassium 3.8 mmol/L (3.5-5.3) [was 3.4 in may '17]

Serum creatine 73 umol/L (45-84) [was 86 in may '17]

Thank you

2 Replies
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You B12 is very low. The previous in-range results were almost certainly due to taking supplements.

You need to be started on a course of B12 injections. The frequency of these will depend on your symptoms. Do you have neurological symptoms (numbness/tingling in fingers and/or toes, depression, anxiety, brain fog)?

1 like
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Thank you for replying.

I have the following ingoing symptoms and am currently off work (teacher) due to them.

Fatigue (sleep about 10hrs a day once I can get to sleep)

Struggling breathing (tightness/ heavy chest, not wheezing)

Palpitations

Dizzyness

Brain fog/lack of concentration/ mixing up words

Numbness in left hand

Pins and needles in legs/tight achilles

Headaches

IBS

Stomach pains - ranging from feeling like it's being twisted to 10/10 and I will black out whilst led down (currently managed by eating 1 meal per day)

Eczema

itchy dry eyes and eyebrows (eyebrows now starting to thin)

Extreme irritability - worse with loud noises or multiple people talking at once

Allergies to environmental (dust/pollen/mould/grass/etc)

Sore joints (right wrist and knee, hips)

Poor appetite/ slow to digest

Tonsillitis for last 2 months, with intermittent loss of voice

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