Hi I have been advised by the thyroid UK forum to come here, I have high antibodies (Hashimotos) and I have posted symptoms and results below. Supplementing 210mg ferrous fumarate once a day and 800iu vitamin D3 both on prescription and taking 25mcg Levothyroxine for the hypoythyroidism/Hashimotos diagnosed in 2012. Thank you Advice welcome.
Serum folate 2.0 ug/L (2.50 - 19.50 ug/L)
Serum vitamin B12 214 pg/L (190 - 900 pg/L)
Serum ferritin 56 ug/L (30 - 400 ug/L)
Iron 9.2 (6.0 - 26.0)
Transferrin saturation 13 (10 - 30)
MCV 77.1 fL (80 - 98 fL)
MCHC 386 (310 - 350)
MCH 28.1 (28 - 32)
RBC count 4.41 (3.80 - 5.80)
WBC count 6.17 (4.0 - 11.0)
Platelets 228 (140 - 400)
Haemoglobin estimation 120 (115 - 150)
Neutrophil count 0.5 (0.0 - 1.0)
Basophil count 0.0 (0.0 - 0.2)
Eosinophil count 0.2 (0.0 - 0.5)
Monocyte count 0.8 (0.0 - 1.0)
Lymphocyte count 1.4 (0.5 - 2.0)
Copied from Thyroid UK main site:
Excessive tiredness
High cholesterol
Cold extremities
Slow movements
Slow speech
Pins and needles
Breathlessness
Palpitations
Anaemia
Lack of co-ordination - especially of hands and feet
Insomnia
Loss of libido
Repeated urinary tract infections
Heavy eyelids
Hoarse voice
Goitre
Muscle cramps and weakness
Joint stiffness
Heat/cold intolerance
Low basal temperature
ADHD
Vertigo
Balance problems
Dizziness
Puffiness of eyes
Puffiness of face
Puffiness of feet
Puffiness of ankles
Difficulty swallowing
Sore throats
Swollen tongue
Choking fits
Dry mouth
Sensation of lump in throat
Numbness in legs
Numbness in toes
Memory loss and confusion
Mental sluggishness
Poor concentration
Loss of drive
Nightmares
Body hair loss
Head hair loss
Brittle hair
Eyebrow loss
Eyelash loss
Brittle nails
Flaky nails
Dry skin
Flaky skin
Pallor
Boils and spots
Eczema
Bruising
Migraines
Pressure headaches
Back and loin pain
Wrist pain
Carpal tunnel syndrome
Burning feet syndrome
Alcohol intolerance
Constipation
Abdominal distension/flatulence
High blood pressure
Slow/weak pulse
Heavy periods
Poor focusing
Double vision
Dry eyes
Gritty eyes
Blurred vision
Noises in ears
Deafness
Tinnitus
Easily upset
Wanting to be solitary
Depression
Lack of confidence
Increased sweating
Weight loss
Shakiness
Infertility
Longer cycles
Written by
LizzieJ8
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your blood work is characteristic of microcytosis - consistent with iron deficiency
your folate is below range and your B12 is on the low side
if you have a history of B12 levels that shows a downward trend then that would be the clincher in relation to an absorption problem specifically relating to B12.
Are these results from a private blood test? If so suggest that you share with your GP along with details from the above post
Thanks very much for this information. B12 has been low more often than high but on occasion has shot up despite not supplementing or change in diet. The results are from an NHS blood test and GP is deciding not to take action on below range folate. I will go back to GP on Tuesday and insist they do something.
if you have a positive for IFA and you weren't supplementing then that means that you have PA in the sense of an autoimmune response that is attacking the mechanism that allows you to absorb B12 - it can also lead to reduced stomach activity which will affect your ability to absorb other vitamins and minerals.
Your GP should definitely be treating you with loading shots (using the more aggressive regime for neurological involvement*) and then on to loading shots every 2 months - though no guarantee that that would be enough as a maintenance regime.
* 3xweekly until symptoms stop improving - review at 3 weeks.
the other issue would be around the timescales on the symptoms - if they came on quickly that would point to the folate deficiency - if they have developed slowly then that would point to B12 - the overlap with thyroid does make it all very difficult to evaluate what symptoms are caused by what though - so think approach to take with GP is getting them to a) look at absorption problems and b) be open to the idea that there is more than thyroid going on.
When you say shot up - how much? another thing to check is that the same units have been used each time as test results can be expressed in two different units - ng/L and pmol/L - though the results above are from measures that would produce the higher figures.
Just wondering, can/does the auto-immune process fluctuate, thus causing a change in B12 levels? I'm asking coz I don't have a clue but it could potentially be why results are up, then down, then up again etc???
I believe there are a few conditions (eg liver and kidney problems) that can cause the liver to dump the B12 that it is storing, resulting in raised B12 levels - but think the implication is that these would normally raise levels above the top of the normal range.
LizzieJ8 Prior to Feb last year it looks as if the levels were quite stable then they shot up in August 2016 and have been falling ever since. The drop is quite significant and would support an absorption problem - and IFA being positive would suggest that was PA.
The PAS has a microsite aimed at medical professionals - you could suggest to your GP that they take a look at it if they want to understand more about B12.
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Blood results as requested on my other thread
could someone check my test results please to explain them to me?
Some test results 
FBC Test results help please
