Reasons for high B12???

[Daisykalita]

In the last week of may, did my blood test. And found that my B12 is 1535. Anyone can say what is reason behind this. My vitamin D is 125.

[clivealive Forum Support]

Do you eat a lot of meat, fish, eggs, seafood, poultry or dairy produce?

Doe you know what your Folate level is?

Do you feel well in yourself?

[Daisykalita in reply to clivealive]

Daily 1 egg and 1cup of milk. Other product rarely I take.

[Daisykalita]

I took All 9 D. it contains L-methylofolate calcium,mecobalamin, pyridoxamine 5 phosphate, DHA and vitamin D3 from Aug '16.

[Galixie in reply to Daisykalita]

Your supplement contains B12 (the mecobalamin you listed above).

[Daisykalita in reply to Galixie]

Thanks a lot

[Simplicity17]

I had exactly the same thing...my B12 level was 1410. This prompted my doctor to check if I had a genetic defect called MTHFR...of which I was positive for BOTH genes being defective. What this means is that B12 stays in the blood because it is not able to be absorbed into the muscle, nerves or tissues. She said that high levels of B12 in the blood are an indicator that there's an absorption problem that needs to be rectified, for which I'm now being treated.

[Cherylclaire Forum Support in reply to Simplicity17]

I was diagnosed with Functional B12 Deficiency when my B12 went from 196ng/L in Feb 2016 to over 2000ng/L after treatment: MMA was checked - 6/10/16- and found to be high which confirmed the diagnosis. My blood is currently being tested for genetic mutations relating to this condition, because my MMA continues to rise and 1 injection a month is not enough to stabilise symptoms. Also having an MRI brain scan soon.

I hope that Hidden was right about your dosage being the cause of your high readings Daisykalita - easy to sort out !

Can I ask you, Simplicity 17, what treatment you are getting to rectify your condition ?

[Simplicity17 in reply to Cherylclaire]

I cannot absorb ANY regular B12. My doctor said I could have eaten a cow a day and it would have made no difference B12-wise. I now take sublingual methyl B12 AND methylfolate supplements. You have to take both supplements together as they work off of each other. And sublingual supplements are best because they are more easily absorbed, as opposed to a pill that is only fractionally effective.

As well, I respectfully disagree with high dosage being the cause of your high readings. If you go from a functional deficiency to ultra-high readings, that is still indicating some type of absorption issue. Ask your physician for an MTHFR test. Everything else you've stated, right down to your MMA levels, is (IMHO), pointing to this as your issue.

[Cherylclaire Forum Support in reply to Simplicity17]

No I don't think that my subsequent high readings were anything more than just inability to absorb B12 at tissue level- blood is swimming in it, symptoms remain because tissues are getting not very much of it, that's why methylmalonic acid (MMA) left hanging and level remains high in blood. St Thomas' confirmed GP's diagnosis of Functional B12 deficiency, MMA now higher than when this was diagnosed last October. Even with regular injections (was 2 a week for about 6 months and now once a month)- which I know is not supposed to happen ordinarily. But what is "ordinary" about this ?

Cannot ask for any particular genetic tests, as this has been organised by hospital haematology department- bloods sent to laboratory via hospital, so out of my hands now. Assuming that the genetic mutation tests are for reason that I can't get B12 to tissues, and will include MTHFR test. Also assuming MRI brain scan will be checking for lesions.

Have to hope they all know their B12 stuff !

The funny thing to me : why would someone with absorption issues not be given injections over sublinguals, sprays or tablets- taking it further down the pathway, so to speak?

[Simplicity17 in reply to Cherylclaire]

Addressing your last question: most injections of B12 given by physicians are not the methyl type. That specific kind has to be prepared by a compounding pharmacy, is very expensive, and is rarely (if ever) covered by insurance. Take a moment to call your physician and ask which type he/she gives to their patients. That leaves: methyl B12 sprays ~ which are very difficult to find and expensive when you do (and never contains the necessary methylfolate, as well), which leaves tablets/capsules vs. sublingual applications. Medical science has proven that sublingual is preferable for entry into the blood stream. I am sure there are a multitude of sites on the internet that can explain it with better clarity than I'm obviously failing to do here. All the best.

[Bonniepun in reply to Simplicity17]

I have MTHFR mutation also. I'm given the optimized folate. What other supplement did your doctor give to you? My homocysteine has come down drastically but b12 still high. I was told it'll stay that way.

[Simplicity17 in reply to Bonniepun]

Hi...

Basically the same as you ~ the optimized folate WITH the methyl B12 at the same time, as they both need each other simultaneously to work. I found the best kind that works for me is Jarrow sublinguals. Very glad to hear about your homocysteine level coming down. It's a lifelong pursuit to maintain low levels, but at least there is something we can do to address it. High B12 shouldn't be problematic like high homocysteine levels. All the best.

[Bonniepun in reply to Simplicity17]

I have MTHFR mutation also. I'm given the optimized folate. What other supplement did your doctor give to you? My homocysteine has come down drastically but b12 still high. I was told it'll stay that way.

[fbirder]

Interestingly, there was, until recently, an erroneous entry in Wikipedia that said people who only supplement with methylcobalamin should also take adenosylcobalamin (or hydroxocobalamin) as methyl couldn't get converted to adenosyl.