Platinum challenge - reversing platinum resistance

[Phuket]

Hello All

I am platinum resitant after recurring just 2 months after 1st line treatment. Am now on 2nd line weekly Taxol.

I have been trying to read up a bit about platinum resistance and some medical articles talk about platinum rechallenge ie reintroducing carbo/cisplatin with other drugs to reverse the resistance.

I am just wondering what everyone's experince is of this and whether anyone has been retreated with carbo/cisplatin succesfully? Did the cancer respond? If so can you share your experiences?

In particular I'm interested to know how long you had to wait after your last platinum treatment before it was retried?

Thank you!

[Yoshbosh]

Hi Phuket,

I am in a similar situation to you - I’m technically platinum resistant since my second recurrence was picked up at 5 months since finishing carboplatin. I went on to clinical trial that didn’t work for me, then gave weekly taxol a shot which had a decent response for about 4 months before it stopped being effective. As it has now been a year since I last had platinum chemo, I’ve just started carboplatin and gemcitabine. No guarantees it will work, but apparently the two have a synergistic effect and the gemcitabine can help ‘re-sensitise’ the cancer to the platinum treatment. I’ve only done one cycle so far so it is far too soon to say if it is working.

I hope that gives you some info.

Vicki x

[Neona]

I recurred during frontline carbo and taxyl and was told thete was no point in me having either again. I was offered caelyx but decided to go for a second opinion and am now on a clinical trial.

[DianesK]

Hi

I was told after 3rd line that was was resistant and no point in trying again.

I went on caylex which wasn’t successful. I changed oncologists and now I am on weekly taxol with carbo every 3weeks and so far it is responding and my CA125 has gone down from 2153 to 670 after 3 cycles of carbo.

I don’t understand why but glad it has

Good Luck xx 🌻

[ssjmichael]

I came across a drug being used in a clinical trial, and from what I can tell, it may have the ability to resensitize people to platinum again. The drug is called guadecitabine, and is known as a hypomethylating agent. There is another one tested too called azacitidine This may be a game changer in the future if it can work.