Good CA125 result again: Hi everyone. Just a... - My Ovacome

My Ovacome

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Good CA125 result again

drdu profile image
drdu
37 Replies

Hi everyone.

Just a quick post to say that my CA125 was 6 again this week. It is now over 4 years since my last dose of chemo - Nov 7th 2014. And it will be 10 years soon since diagnosis in early September 2009. I am so thankful that ibuprofen appears to be working for me as an anti-cancer agent. More info is coming out regularly re aspirin and ibuprofen/other NSAIDs as agents against cancer. See my last post a few days ago.

It seems oncologists are willing these days to recommend or agree to use of aspirin in particular, 75mg once daily to try to prevent cancer recurrence. And there is increasing evidence that this is effective for some with cancer. Please see my previous posts.

Best wishes to you all.

Eileen x

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drdu
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37 Replies
Katmal-UK profile image
Katmal-UK

Great news! long may yr good health continue xx

MH500 profile image
MH500

Great news Eileen

I often think about how you are doing.

Re the NSAIDS....Do you think that you need a specific gene mutation for this to work, or is it a help to us all?

Marian x

drdu profile image
drdu in reply to MH500

The specific gene mutation I wrote about a few days ago (PIK3CA) is obviously an important discovery re how aspirin and NSAIDs work against cancer. However it is thought that aspirin and NSAIDs may work in other ways against cancer, and these need more research to sort out. See an article I have linked to before

journals.plos.org/plosone/a...

This is a very good article from 2016, and mentions PIK3CA. Note especially under Results, and Conclusions and Implications in the Abstract at the start. Note also, under Introduction, the important paragraph starting Chan et al... Cellular apoptosis means killing of cells. And see the Conclusions at end of article - very important. There is a need for more trials, they say. In the meantime, they say, aspirin should be considered as an additional treatment in cancer patients - oncologists should discuss this with their patients.

Hope this helps. Basic message: aspirin/NSAIDs may help v cancer in a variety of ways, in addition to PIK3CA mutation, yet to be discovered/proven by trials. So it is still worth trying.

Best wishes.

Eileen x

RonLitBer profile image
RonLitBer in reply to drdu

A good article thank you. It does mention the PIK3CA mutation so interesting to have the more current articles as further confirmatory statements.

drdu profile image
drdu in reply to RonLitBer

Yes indeed.

E x

ElayneZ profile image
ElayneZ

OTC ibuprofen is 200mg in the US. Seems I read the dosage suggested here is 75mg ibuprofen - is that right? Thank you. It’s truly wonderful and encouraging to read positive posts!! Thank you for sharing!

Petrolhead profile image
Petrolhead in reply to ElayneZ

In the UK it is available as 200 and 400 mg tablets. (800mg is prescription only) As 100mg meltlet tablets for children. Also as liquid 100mg per 5ml.

So if you wanted 75mg you would have to take 3.75ml of the liquid via a medicine syringe. Just info if you needed it.

Fay

ElayneZ profile image
ElayneZ in reply to Petrolhead

Thank you Fay. I thought I read to get a script from the doctor for the lower dosage which confused me since 200mg is otc. Hope you are doing well! Blessings!

drdu profile image
drdu in reply to ElayneZ

No, the dose of aspirin is 75mg once daily. I think you have a different size of aspirin in the USA. It is a very small dose of aspirin, often called "baby aspirin" here, but found to be sufficient. I take ibuprofen 400mg three times a day, but you MUST take a stomach protector like omeprazole 20mg daily if taking ibuprofen or similar to protect from stomach bleeds. All this needs to be discussed with your doctor/oncologist. Don't take both ibuprofen and aspirin - take one or the other.

Best wishes.

Eileen x

Manchesterlady profile image
Manchesterlady

So pleased that it’s working for you , long may it continue. Good luck

Sheila x

drdu profile image
drdu in reply to Manchesterlady

Thank you very much, Sheila. All best wishes to you.

Eileen xx

Lind58 profile image
Lind58

Great news! Long may it continue :)

drdu profile image
drdu in reply to Lind58

Thank you very much. All best wishes to you.

Eileen xx

Petrolhead profile image
Petrolhead

Good news again.

Did you see that Dr Stewart Adams who was the lead discoverer of Ibuprofen (trade name Brufen) died just a day ago aged 95. He used it as a hangover remedy as we all did! (Still do if needed but not as much as when I was in my clubbing days). Even better as a hangover prevention. A couple of tablets with a big glass of water after a night out before I went to bed. No hangover. 👍.

Happy days

Fay

drdu profile image
drdu in reply to Petrolhead

No, I didn't see that. Actually it's probably not a good thing to take after a load of alcohol because of risk of irritating stomach and causing bleeding, but never mind, you have got away with it! Paracetamol, 2 x 500mg tablets, is safer! Yes, those were the days!

All best wishes.

Eileen x

Zssu profile image
Zssu

Great news Eileen, This subject is on my list for discussion with my oncologist next week. I am wondering why you have not had a parp inhibitor? Is it because the ibuprofen works for you and you not brca affected?

drdu profile image
drdu in reply to Zssu

Yes, exactly. Ibuprofen works for me, fortunately, and so Parp inhibitor not needed. And I am BRCA negative.

Best wishes.

Eileen xx

Peg8080 profile image
Peg8080

That is awesome news! Thank you for sharing! Long may your great results continue! 💖 Peggy xx

drdu profile image
drdu in reply to Peg8080

Thank you very much, Peggy. Good luck and all best wishes to you.

Eileen xx

ladygooner-uk profile image
ladygooner-uk

Hi Eileen congrats to you!

I have just passed my 10 year survival anniversary, I haven't tried aspirin, did take turmeric for a year, but stopped it due to bowel issues( too much info, I know!) Will ask my onc about the aspirin when I go for check up at the end of the month tho. am on 6 monthly check ups now, due end Feb. Still got my fingers and toes crossed.

Sue

X

drdu profile image
drdu in reply to ladygooner-uk

Hi Sue. I remember seeing your name over the years. Thanks very much. Yes, looking at your past story, I would think aspirin might well be a good idea, worth discussing with your oncologist.

Congrats to you on passing 10 years. Good luck at end of February.

All best wishes.

Eileen xx

Hopefulgal1 profile image
Hopefulgal1

So amazing and encouraging... I really applaud you. If only I could get down to a low CA125 on my current chemo cocktail 🙏 I shall introduce low dosage (75mg) aspirin. I am currently on a pain killer daily as part of my cocktail ( extoririb) which is a NSAID... who knows we all are willing to do anything. Metformin is also a well documented drug apparently that some people use too ( this needs a prescription) x worth reading up on Andy. Discussing with oncologists to understand these further.

drdu profile image
drdu in reply to Hopefulgal1

If you are on an NSAID then don't add in aspirin, I would say, as you risk stomach bleeding etc and the NSAID should act like aspirin. Yes, discuss all that with your oncologist. Yes, metformin has also got anti-cancer effects.

Best wishes and good luck.

Eileen xx

WoodyB profile image
WoodyB

Fantastic news, Eileen. If there was money to be made in ibuprofen there would be clinical trials all over the place. Very pleased it is working for you and, provided you (as I know you do) take a stomach protection drug, there is no need to watch your blood counts closely like there is for PARP inhibitors. Long may it continue to do the job xx

RonLitBer profile image
RonLitBer in reply to WoodyB

clinicaltrials.gov/ct2/show...

drdu profile image
drdu in reply to RonLitBer

Thanks very much for that link. This trial is looking at aspirin (acetylsalicylic acid) as a possible preventive of ovarian cancer, rather than a treatment, it appears. But it is a good start. Thanks again.

Eileen xx

drdu profile image
drdu in reply to WoodyB

Thanks very much. Yes, a good stomach protector like omeprazole 20mg daily is essential if taking an anti-inflammatory like ibuprofen. Yes, I have been very fortunate in responding to ibuprofen.

Best wishes.

Eileen x

Cyndyc profile image
Cyndyc

Thanks so much for this information and I am now reading all of your previous posts. I am Ovarian Stage 3C and am doing all I can to keep my CA125 down. I finally have hit 12 and am juicing plus cut out all sugar and meat. The chemo makes me so sick I struggle with it so badly I can't even work. I have been battling this for a year now and had such extensive surgery plus a double bowel resection a year ago but am hanging in there.

I would love to read your story and am very interested in trying the ibuprofen.

And where can I get the omeprazole?

Also can you share the link to your story? I am definitely going to try the ibuprofen and it will probably help with all this daily pain I have from the surgeries. Even a year later and I suffer so much.

Thanks for sharing this information to help others! God Bless you and I pray that your NED continues! You are an inspiration to all of us!

Cindy

drdu profile image
drdu in reply to Cyndyc

Thanks very much Cindy. My story can be reached by just clicking on my name, and all the details come up. They should do anyway. You should speak to a doctor/oncologist before starting ibuprofen and omeprazole, as I don't know all your past medical story, or what you are taking now. It is possible you might not be suitable to take ibuprofen and omeprazole. Omeprazole can be bought over the counter, in UK, but is quite expensive. You should definitely speak to your doctor/oncologist before starting this.

That is great that your CA125 has got to 12. Good luck with all you are going through.

All very best wishes.

Eileen xx

tanyanpc profile image
tanyanpc

Amazing story! I am so happy for you.

I have PIK3 mutation and this story is definitely something to try. Eileen, do you have BRCA mutation?

drdu profile image
drdu in reply to tanyanpc

Thanks very much. No, I am not BRCA positive. Good luck with everything.

Best wishes.

Eileen xx

ingrid48 profile image
ingrid48 in reply to drdu

Hi Eileen

I'm still here as you, but still battling.

I started in 2011, primary peritoneal (ovarian)

Brca positive, at ca125 3000. I’m in the US

I’m 70 now, had several rounds up and down all the way to ca125 to 7

Became platinum resistant, went to olaparib, then other chemo, now waiting for Zejula to arrive...because now Ca125 is up to 300

I’ve had some good years and I’ve seen all my grandchildren being born and enter school! which I didn’t think I would.

At one point I was taking ibuprofen and Omeprezole because I saw your posts and it was working great.

Then on one chemo I was not supposed to take any extra med and I stopped

I also lost you!

Found you again and not on chemo.

I’m going to take Zejula soon and go back on omaprezole and ibuprofen

I believe that cancer is caused by inflammation and infection

My doctor also wants to check into an upcoming immunotherapy that will be available in a couple of months in Rockville, Maryland, about half hour from where I reside.

I know you are a doctor. Do you have any suggestions or recommendations for me!

I look forward to hearing from you.

Sincerely

Ingrid

drdu profile image
drdu in reply to ingrid48

Yes, if you get the chance try to get back on ibuprofen and omeprazole if your oncologist is happy with that. Glad you have seen all your grandchildren born and entering school. I feel the same, didn't think I would see any grandchildren. It's lovely.

Good luck with your treatment.

All best wishes.

Eileen x

ingrid48 profile image
ingrid48 in reply to drdu

Thank you.

So glad to hear u are great and I’ll keep u posted from time to time!

God bless us all!!

Ingrid

drdu profile image
drdu in reply to ingrid48

Thanks Ingrid. Yes indeed.

E xx

Melody6 profile image
Melody6

Congratulations, Eileen! That’s great news - hoping you stay in permanent remission and that your excellent results continue. 🎉 🍾 With very best wishes, Mel xx.

drdu profile image
drdu

Thank you very much Mel.

All best wishes.

Eileen xx

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