Hello, I posted a while ago as I was taken off Rinvoq in September due to elevated liver enzymes. Had a 3 month Kennalog injection in October due to a serious flare up that left me bedridden and unable to walk for a week.After a raft of blood tests, MRIs, Xrays and CT scans I was told by Rheumatologist that she wasn't sure what to do next as I needed DMARDs but having been through everything from Methotraxate, to biologics to Rinvoq there wasn't much else left to try and due to liver damage results I was excluded from lots of options. She wasnt in favour of steroids and steroid injections as an option either. I left that appointment feeling very scared and frustrated.
I saw Rheumatologist again just before Xmas and she said she'd like me to try Yuflyma which is a new biosim of Adalimumab, didnt have a great experience with Humira but I've agreed because there really isn't any other option on the table.
I'm just awaiting delivery, has anyone else taken it and if so what results and side effects etc?
Many thanks in advance
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Lucena62
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Hi Lucena62 , I'm so glad to hear a suitable treatment option has finally been found for you, what a relief that must've been after the earlier conversation with your rheumatologist.
I've heard about many people getting great results with Yuflyma, sometimes within a couple of doses, so hopefully that'll be the case for you. I've tried it myself and while it wasn't the answer for me personally, there were no problem side effects and I did appreciate the doses being only fortnightly! The injection is low-volume and citrate-free, so non-stingy and much more comfortable than many of the others. Fingers crossed you'll get a good result 🌼
Thank you VR, I'm hopeful and will try anything. The Humira worked for the RA but my back came out in a mass of varicose and red spider veins which was odd and scary.Hope you found something after Yuflyma
Oh goodness that does sound scary, perhaps it was something specific to the Humira formulation and Yuflyma will be different. Not sure on my next step yet, might be rituximab but we're waiting for a test result to clarify - hopefully it'll come through soon x
I also was switched to Yuflyma and I have to agree that it is very much less stingy than my previous bio-similar. Still not sure it is working as well, but have decided to give a go for a bit longer. I hope you finally get one that works for you.
Thank you, it is a complicated process sometimes, isn't it! I hope you get a good result with Yuflyma in the end - I didn't see any effects at all until 4+ months in, so it seems it can be quite slow to take effect sometimes.
hi. I’m on it. I have been since June. After about 5/6 weeks I really started to notice an improvement. It’s taken a long time for me to get well, they have subsequently added leflumide and my yuflyma injection is now weekly. With 2 months of that I am getting there now. 🤞🏻it stays that way (it has all come undone this week thanks to norovirus, but that’s another story!)
I do notice that the day after my injection if I’ve had a busy week then I find I am quite exhausted and need a good rest. But start to feel better by lunchtime if i take it steady. Other than that all good.
Have you been on azathioprine? I find that many rheumatologists have forgotten about this useful DMARD. Although if you can find a biological treatment that suits that would be even better.
No I haven't but good to have as an option. Over 13 years I've had methotraxate tablets, methotraxate injections, sulphalzine, leflunomide, several biologics and DMARDS
Just been put on this alongside MTX which I've taken for over a decade. Started 23 rd December had my second lot so far so good. Was nervous about starting it, was supervised via video for first time which was fine, nurse was lovely.
So glad you have been given another option, especially after your initial consultation. I hope and pray this works for you. I haven't tried it myself but from what others have said there is a positive response with many.
Thank you Wilfdog, it's been a very troubling time and the thought of living without any dmard support is scary, the Dr has high hopes so we shall see. I got the green light on 23rd December but no sign of meds yet, I can feel the Kennalog is pretty much at the end of it's run so will be chasing tomorrow.Will keep you posted on progress
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Methotrexate 
Severe Reaction to Hydroxychloroquine
Rinvoq (upadacitinib)
Left confused by my visit to the rheumatologist.
