yuflyma - adalimumab

[skinclinic]

Has anyone had experience with the Biosimilar Yuflyma ( Adalimumab)

I’ve been having fortnightly injections for the last 2 months

I was on injectable methotrexate but became quite ill with it after 2 yrs use

I’m now going through a terrible flare in my hands wrists fingers knees ankles and shoulders- in so much I cannot walk , dress or even hold a glass to drink - far worse than in the last 5 years that I’ve encountered

Am I being impatient - how long do I need to wait to know if it’s going to be effective or not ?

I do have a hospital appointment this Friday to see the rheumatology nurse specialist… but guessing I may be told that it’s going to take longer to be effective but I’ve had no relief at all so

[Tealblue2]

hi.

I’m almost in the same boat as you. I’m about to have my 5th injection next week. I was in a treble state a week or two ago, until I had the 4th injection- that seemed to turn the corner for me - but I had to massively increase the steroids to get me there. But this last week I can walk and move more than I have been able to in 3 months. Like you methotrexate made me very ill, then coming off it made everything worse.

I still have some swelling and am finding that my hands and feet are painful at night. But the improvement is amazing considering the time scale.

I really hope things get better for you soon!

[Theoddjobman in reply to Tealblue2]

I am really encouraged by your reply. I take methotrexate injections and now yuflyma also fortnightly. I have been feeling worse in the first 4 weeks. Will persist now in the hope of improvement.

[Tealblue2 in reply to Theoddjobman]

I felt worse before I got better. Fingers crossed for you!

[skinclinic in reply to Tealblue2]

Thanks Teslblue2 . Yes I do hope it will kick in soon … To date this is the worst and most debilitating bout of RD that I’ve ever had

[oldtimer2]

I had almost instant relief with adalumimab (sorry!) but other people have said it takes longer. You could ask for a short course/injection of steroid to tide you over until it starts working?

[skinclinic in reply to oldtimer2]

Hi Oldtimer

I’m glad you had early relief… and I will be asking my rheumatology nurse specialist this Friday for more steroids .. I have been taking 2 pred daily but it seems I now need to move on to a higher dose for awhile

Thanks for replying

[RAat13]

Hello.After 2 months you should've seen some difference but it can rake 12 weeks, I have no positive for that drug as I had a horrible complication from it. What has your Rheumy said?

[skinclinic in reply to RAat13]

Hi RÃat13

I did hope that I’d get some relief especially as this has being going on since August last year and I was without RÃ meds for 6 months ( due to Latent TB antibiotics )

Maybe I’m being too optimistic in a 2 month time and also I had a dental abscess and the tooth extracted which really kicked things off .

5 years ago I had a dental abscess and a tooth extracted because of it ….. and it was then that my RÃ was initially triggered .So maybe my current debilitating flare has been induced by the same abscess/ extraction. And it’s probably been too bad a flare for my new Biologic to ge effective yet

Thanks got taking the time to reply to my question

[RAat13 in reply to skinclinic]

Anything can trigger a flare especially infection, I had a toe removed in January 2023, I had an infection that was caused by the head of damaged joint trying to make its way out.. which caused an 8 month flare and ILD, I've just realised I've confused 2 biologics, the adalimumab (Humira) did work for me for a few years before it stopped altogether, abatacept is what caused problems for me,.. I'm so sorry!I would speak to your nurse or consultant and ask for some advice..

I hope you start to feel better.

I was put on Rituximab in August last year after the worst year of my life and it's given me life back, I did have to learn a new normal again but I'm well and pretty much in Remission after 22 years, ❤️

[skinclinic in reply to RAat13]

Hi RÃ at13

Thanks for your reply

Glad to here that you’ve got your life back after 22 years

Thanks for your well wishes - hopefully I will get some help tomorrow when i attend for my rheumatology appointment

[virtualreality]

Hi there, I'm in a very similar situation to you, recently started adalimumab and not seeing any improvements at the two month stage. In fact, symptoms are worse because I had to stop one of my other medications when I started it. The plan for now is to give it a full six month trial, and to have a steroid injection for symptom relief while the adalimumab (hopefully) gets going. See what happens. How did your rheumatology appointment go, was it any help?

[Tealblue2]

I thought I’d see how you are doing now? In my elation last week for feeling the most well I have in years, I managed to forget that I’d upped my steroids. When they were reduced again and starting wearing off, I crashed. Not the worst flare I’ve had, but it’s getting steadily worse as the week is progressing.

I’ve spoken to the rheumatologist nurse today who’s putting the steroids back up again to get me through the next month until my appointment with her. But she said it’s best if I go back on to methotrexate as well and I need to think carefully about it as it’s my best option to make this work. The problem is methotrexate wasn’t working very well for me and I became very ill and wound up in hospital for a week because my heart was in a state. Now I don’t know if that was a reaction to the methotrexate or such bad inflammation that I got poorly. But I’m really worried now. But I did not feel well at all the year I was on it and hated the side effects. I’m convinced it caused depression- but they tell me I’m mad and it wasn’t possible. I don’t know what to do! The biologics aren’t working well enough- i am pacing in that I’m only active 12 hours and am resting or in bed 12 hours a day and I’m not at work until I start a new job in 10 days. They told me this is stress induced- but I’m excited to start and my life is no where near as stressful as the last 5 years. I’m anxious because I don’t feel at all well not the other way around. Living like this isn’t feasible given my situation- but I’m not sure I can put myself through the hell of methotrexate again and run the risk of loosing another job because I’m so ill. I really don’t know what to do….