Has anyone had experience with the Biosimilar Yuflyma ( Adalimumab)
I’ve been having fortnightly injections for the last 2 months
I was on injectable methotrexate but became quite ill with it after 2 yrs use
I’m now going through a terrible flare in my hands wrists fingers knees ankles and shoulders- in so much I cannot walk , dress or even hold a glass to drink - far worse than in the last 5 years that I’ve encountered
Am I being impatient - how long do I need to wait to know if it’s going to be effective or not ?
I do have a hospital appointment this Friday to see the rheumatology nurse specialist… but guessing I may be told that it’s going to take longer to be effective but I’ve had no relief at all so
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skinclinic
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I’m almost in the same boat as you. I’m about to have my 5th injection next week. I was in a treble state a week or two ago, until I had the 4th injection- that seemed to turn the corner for me - but I had to massively increase the steroids to get me there. But this last week I can walk and move more than I have been able to in 3 months. Like you methotrexate made me very ill, then coming off it made everything worse.
I still have some swelling and am finding that my hands and feet are painful at night. But the improvement is amazing considering the time scale.
I am really encouraged by your reply. I take methotrexate injections and now yuflyma also fortnightly. I have been feeling worse in the first 4 weeks. Will persist now in the hope of improvement.
I had almost instant relief with adalumimab (sorry!) but other people have said it takes longer. You could ask for a short course/injection of steroid to tide you over until it starts working?
I’m glad you had early relief… and I will be asking my rheumatology nurse specialist this Friday for more steroids .. I have been taking 2 pred daily but it seems I now need to move on to a higher dose for awhile
Hello.After 2 months you should've seen some difference but it can rake 12 weeks, I have no positive for that drug as I had a horrible complication from it. What has your Rheumy said?
I did hope that I’d get some relief especially as this has being going on since August last year and I was without RÃ meds for 6 months ( due to Latent TB antibiotics )
Maybe I’m being too optimistic in a 2 month time and also I had a dental abscess and the tooth extracted which really kicked things off .
5 years ago I had a dental abscess and a tooth extracted because of it ….. and it was then that my RÃ was initially triggered .So maybe my current debilitating flare has been induced by the same abscess/ extraction. And it’s probably been too bad a flare for my new Biologic to ge effective yet
Thanks got taking the time to reply to my question
Anything can trigger a flare especially infection, I had a toe removed in January 2023, I had an infection that was caused by the head of damaged joint trying to make its way out.. which caused an 8 month flare and ILD, I've just realised I've confused 2 biologics, the adalimumab (Humira) did work for me for a few years before it stopped altogether, abatacept is what caused problems for me,.. I'm so sorry!I would speak to your nurse or consultant and ask for some advice..
I hope you start to feel better.
I was put on Rituximab in August last year after the worst year of my life and it's given me life back, I did have to learn a new normal again but I'm well and pretty much in Remission after 22 years, ❤️
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