yuflyma - adalimumab

[skinclinic]

Has anyone had experience with the Biosimilar Yuflyma ( Adalimumab)

I’ve been having fortnightly injections for the last 2 months

I was on injectable methotrexate but became quite ill with it after 2 yrs use

I’m now going through a terrible flare in my hands wrists fingers knees ankles and shoulders- in so much I cannot walk , dress or even hold a glass to drink - far worse than in the last 5 years that I’ve encountered

Am I being impatient - how long do I need to wait to know if it’s going to be effective or not ?

I do have a hospital appointment this Friday to see the rheumatology nurse specialist… but guessing I may be told that it’s going to take longer to be effective but I’ve had no relief at all so

[Tealblue2]

hi.

I’m almost in the same boat as you. I’m about to have my 5th injection next week. I was in a treble state a week or two ago, until I had the 4th injection- that seemed to turn the corner for me - but I had to massively increase the steroids to get me there. But this last week I can walk and move more than I have been able to in 3 months. Like you methotrexate made me very ill, then coming off it made everything worse.

I still have some swelling and am finding that my hands and feet are painful at night. But the improvement is amazing considering the time scale.

I really hope things get better for you soon!

[Theoddjobman in reply to Tealblue2]

I am really encouraged by your reply. I take methotrexate injections and now yuflyma also fortnightly. I have been feeling worse in the first 4 weeks. Will persist now in the hope of improvement.

[Tealblue2 in reply to Theoddjobman]

I felt worse before I got better. Fingers crossed for you!

[skinclinic in reply to Tealblue2]

Thanks Teslblue2 . Yes I do hope it will kick in soon … To date this is the worst and most debilitating bout of RD that I’ve ever had

[oldtimer2]

I had almost instant relief with adalumimab (sorry!) but other people have said it takes longer. You could ask for a short course/injection of steroid to tide you over until it starts working?

[skinclinic in reply to oldtimer2]

Hi Oldtimer

I’m glad you had early relief… and I will be asking my rheumatology nurse specialist this Friday for more steroids .. I have been taking 2 pred daily but it seems I now need to move on to a higher dose for awhile

Thanks for replying

[RAat13]

Hello.After 2 months you should've seen some difference but it can rake 12 weeks, I have no positive for that drug as I had a horrible complication from it. What has your Rheumy said?

[skinclinic in reply to RAat13]

Hi RÃat13

I did hope that I’d get some relief especially as this has being going on since August last year and I was without RÃ meds for 6 months ( due to Latent TB antibiotics )

Maybe I’m being too optimistic in a 2 month time and also I had a dental abscess and the tooth extracted which really kicked things off .

5 years ago I had a dental abscess and a tooth extracted because of it ….. and it was then that my RÃ was initially triggered .So maybe my current debilitating flare has been induced by the same abscess/ extraction. And it’s probably been too bad a flare for my new Biologic to ge effective yet

Thanks got taking the time to reply to my question

[RAat13 in reply to skinclinic]

Anything can trigger a flare especially infection, I had a toe removed in January 2023, I had an infection that was caused by the head of damaged joint trying to make its way out.. which caused an 8 month flare and ILD, I've just realised I've confused 2 biologics, the adalimumab (Humira) did work for me for a few years before it stopped altogether, abatacept is what caused problems for me,.. I'm so sorry!I would speak to your nurse or consultant and ask for some advice..

I hope you start to feel better.

I was put on Rituximab in August last year after the worst year of my life and it's given me life back, I did have to learn a new normal again but I'm well and pretty much in Remission after 22 years, ❤️

[skinclinic in reply to RAat13]

Hi RÃ at13

Thanks for your reply

Glad to here that you’ve got your life back after 22 years

Thanks for your well wishes - hopefully I will get some help tomorrow when i attend for my rheumatology appointment