So to update everyone. I have been unable to tolerate methotrexate, subcut methotrexate, sulfasalazine or hydroxycholquinine but have very active RA. The next step was going to be lefludomide but I was very reluctant to take it. I had an emergency appointment with the consultant on Tuesday.
They confirmed extensive swelling everywhere. They confirmed lefludomide would be the next option however my blood pressure was a bit high and with my history of gut sensitivity it seems they were also reluctant to try it.
At this point I suggested that perhaps we go with what my American Doctor friend had suggested. They wondered if I might have the MTHFR gene which prevents synthetic folic acid being absorbed. Instead it backs up in the liver and causes other symptoms. I've always felt the synthetic folic acid I was prescribed made me ill.
I suggested I rechallenge the subcut methotrexate but instead of taking the prescribed folic acid I take the methylfolate version and combine this with the natural form of B12 (need both to synthesize it properly). I also suggested I combine all this with BCM-95 curcumin extract (turmeric) as it has been shown in some small scale trials that this form has some protective elements over the liver and kidneys as well a anti inflammatory properties when taken with methotrexate.
To my surprise the consultant thought about it and said why not. What is there to lose. They would also bring it to the attention of the rheumatoid pharmacist. They would be interested in the results.
I made it clear I wasn't a natural remedies obsessive or anything like that and I feel the jury is still out as to whether there is any real substance behind the MTHFR gene theory but it was worth a try. If it didn't work we would have to look at an alternative.
Don't know if anyone else has tried this approach?