My GFR went from 54 in 2014, to 41 last month. My cholesterol is 254. I have to go redo my blood tests in 2 month. My GP told me that he is baffled at why my GFR keeps dropping. My blood pressure is good, I am not a diabetic. After reading all of your posts, I think I know why GFR is decreasing. I have had back problems for years and I have taken so much ibuprofen. My GP prescribed Percocet, but it does not last long, so I still take ibuprofen. I do not drink water, but a lot of ice tea. I am going to stop taking ibuprofen and start drinking water instead of ice tea and see if it makes a difference in my GFR. I am a nurses aide and my job is really hard on my back, I just hope I can stay away from NSAID's. Has anyone else's B12 level been low. My homocysteine level was 12, so he now gives me B12 shots.