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Macrocytosis and daily water recommended

I have had PV for 5 years, male 53 years old , treated with hydroxycarbamide, now I have Macrocytosis , corpuscular volume (MCV) of around than 100 femtolitres my hem recomended 5mg folic acid daily.

Has somebody this problem ? How influence?What treatment ? etc.

Other question How much water is recommended to drink per day ?

Any comments please.

5 Replies

Can you tell me more about what Macrocytosis is? I must confess I have never heard of it. I have had PV for one year,treated with Hydroxycarbamide and I aim to drink 4 litres of water per day. When I don't drink enough I do not feel so well. I am struggling to understand why, when my blood is showing satisfactory readings on all counts I still feel very unwell sometimes.


Macrocytosis is a term used to describe red blood cells that are larger than normal. It typically causes no signs or symptoms and is usually detected incidentally on routine blood tests.

Macrocytosis isn't a specific disease, but it may indicate an underlying problem that requires medical evaluation. Common causes of macrocytosis include:


A side effect of certain medications, such as Hydroxicarbamide


Anyway the water is very good for this .

What symptoms do you have?

Why you drink 4l of water?

Is not to much?

Have you side efect due drinking water?

keep in touch


I have seen normal MCV quoted as between 80 - 99. If that is correct then yours is just over the limit. I have checked my most recent result and mine is 135 and nobody seems particularly concerned about it as it is a side effect of taking Hydroxy - which I've been on for 18 years+. I have post ET MF now. 4 litres of water a day seems an awful lot. Did you ask your haem what the folic acid was going to do for you? Whenever a doctor recommends another drug to me I always ask what it will do for me and why he/she is recommending it. If you are worried, go back to your haem and ask questions. Hope that helps.


Folic acid, known as folate in its natural form, is one of the B-group vitamins.

Folate has several important functions. For example, it:

works together with vitamin B12 to form healthy red blood cells .

Normally you found this in greens and diminuate volume to red cell at good level.


Hi, I am with crazydaisy on the water: the more i drink the better i feel.


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