When I was 49 I had a hip replacement and a year later I felt off so the doctor ordered a blood test in which it came back my platelets being too high. (1000) I was sent to a specialist straight away and was put on aspirin then Interferon. After an eighteen months I stopped taking them but eventually the platelets started to go up again so the specialist put me on Hydoroxy. I was on these for quite a while up until three years ago when my platelets started to drop so I was taken off them. Since then I have been taking Jakavi but the specialist wanted me to have a blood transfusion in which I wasnt very happy about so I started taking iron tablets. My platelets have gone up a little so I dont need a transfusion at the moment. I get very tired and have put allot of weight on since I have been on this drug. Is there anybody out there that has had a hip replacement then found out after a while they have a blood problem as I read a while ago that it can cause this after having an operation?
Hip Replacement : When I was 49 I had a hip... - MPN Voice
Hip Replacement
An operation like a hip replacement can cause reactive thrombocytosis. This is a normal and temporary response to the insult to the body. Essential Thrombocythemia (ET) is different in that the thrombocytosis is caused by the upregulation of the JAK-STAT pathway, usually due to one of the three driver mutations, JAK2, CALR, or MPL.
Thrombocytopenia (low platelets) can result from too high of a dose of a cytoreductive medication like Jakafi or due to a change in your MPN status. Reference to taking iron or a whole blood transfusion sounds like treating anemia (low RBCs/HGB). Have you seen a reduction in the levels of your RBC/HGB? Has your diagnosis been changed from ET? This would be important to know in order for you to make good treatment decisions. Note that many people who need a transfusion feel much better after having one. Iron supplements can help in some cases but takes longer to be effective.
Wishing you all the best.
Yes my diagnosis has changed but I never see my results as I have a blood test every two months and my haematologist just sais I am doing ok and then sais to come back in two months. I reduced the Jakafi from two to one as it was pushing my cholesterol up and up to now I dont feel much different. Yes I think you're right about the iron supplements but I dont feel like having a monthly transfusion.
May I ask why you never see your blood test results?
I think you need to correct this situation. There may be several ways of doing this, either your GP, or the specialist. It is important you have access to all your test results and learn how to read them even if just to see if they are going up or down and by how much. I would be very wary of any Dr who wants to keep this hidden from you .
Regarding a link to hip replacement, i was also just wondering about the effects of metal in the body. I had plenty of dental work before dx, braces etc and still have metal bar behind lower teeth. It made me wonder if there might be a link with metal toxicity. 🤷♀️
I had a knee replacement in a private clinic in September 2022 and I was very ill afterwards. I stayed in the clinic a week and was sick the entire time and when I was discharged I felt like I was dying and had to go see my own GP and was immediately sent to the Accident and Emergency Dept (National Health Service UK) . There I found out I had a blood clot in my leg (which can happen during surgery) plus a viral infection and dehydration but during the course of being treated for the blood clot over the next three months, the hospital discovered that I had ET Jak2. I don’t know if I had ET before surgery although I had had a pre-assessment done and bloods checked a few weeks before surgery and all was ok. So I don’t know how long I might have had ET but it only came to light after the blood clot caused by the surgery. So I don’t know if having the surgery was a good thing or a bad thing. I’ve been on hydroxy 500 mg since February 2024 and bloods are doing well but all I can do is keep my fingers crossed. I am very grateful for this site and the comments and queries made as it gives me an idea of what may lie ahead and helps me to be prepared.
Yes it does make you think whether or not the operation caused your ET. Mine was 26 years ago and my hip is still going strong but since then I had to stop my Hydroxy as my platelets came right down and was off them for about eighteen months then my white cells went haywire and started getting night sweats. Thats when he put me on Jakavi but have put on heaps of weight and cant get into my old clothes. Since I have reduced my tablets down to one and so far so good. I hate feeling tired all the time though . I was 49 when I had my hip replacement
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