how do all you people with mpn’s feel about having yet another booster for Covid? I’m only having it if it’s Pfizer like the previous jabs.
Covid jab no.6: how do all you people with mpn’s... - MPN Voice
Covid jab no.6
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HazeBlue
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I’m really not looking forward to having mine. I’m having it together with the flu jab on Saturday 22nd September at my local doctors surgery. The last 3 covid19 vaccinations have made me really ill with full on flu symptoms afterwards resulting in a weeks worth of time off work each time. I’ve got an appointment with my occupational health doctor at work before this next one due to the sickness it has been causing me each time. I’ve never had covid19 so I guess the side affects of the vaccinations are hopefully less than actually getting covid19. I hate the way they affect me as I hate being off work sick.
I was just watching an update on the new COVID vaccine on the news. the doc being interviewed recommended spacing out the COVID booster and flu vaccine by two weeks. I had already planned to do this. Last year I had the flu and pneumonia vaccine at the same time. I had an unusually strong reaction to doubling up on vaccines. I do not plan to repeat that experience.
Definitely agree with not wanting to get sick from the vaccines. Hope your experience goes well.
I feel the same, Haze Blue. Pfizer has suited me for the last 5 . However, my sister had NHS email telling her to book now and had her jab on Sunday. On enquiring she was told that all the roll-out this time is Moderna. Up to now thankfully she’s ok, just a slight sore arm. I’d like to know if it’s the new vaccine just approved for the two latest strains. It’s not quite 3 months since my 5 th so don’t expect to be notified just yet. Fran
In UK as I understand it, the bivalent vax is for Ba.1 version of Omicron. So it is not the latest Ba.4 and ba.5 that are circulating worldwide. But it was tested in a clinical trial while the ba.5 on in the US is not yet so tested. (I plan to get the US version soon) The ba.1 version worked ok against ba.5.
For Moderna:
"Covid-19: UK will roll out Moderna’s omicron BA.1 vaccine as part of autumn booster programme"
For Pfizer:
"‘Comirnaty bivalent Original/Omicron’, half of the vaccine (15 micrograms) targets the original virus strain and the other half (15 micrograms) targets Omicron (BA.1)."
i have been holding off having my next one as it is only Moderna being offered. All my others have been Pfizer and been ok. Not sure if Moderna will be as non reactive or non risky
Moderna is a larger dose (50mcg) than Pfizer (30mcg). There has been a trend that Moderna has more effects than Pfizer, likely for this reason. Similarly there has been a stronger immune effect with larger doses, as in this post (Pfizer is not available in that 60 mcg size):
healthunlocked.com/mpnvoice...
These are the vaxes being offered in UK. But as always there are exceptions and indiv differences and both vaxes are effective.
thanks EPguy. That is helpful.
UK info on approved Pfizer bivalent booster
i had the Astra Zeneca first and had a bit of a sore arm and shiveringfor 12 hours. .Pfizer second and third dose - much more sore arm, but generally ok. Had Modurna for 4th dose. This one really knocked me. Felt so tired and feeling unwell for 3 days. Have to see what the next one does. I know of people who have had the virus after 3 doses and they ended uo in bed for 3 days and a barking coughfor 3 weeks. So I'll take a chance with vaccine.
effective for what? It doesn’t stop you getting it or transmitting it
You're right the vax does not block all infection nor transmission. Unfortunately Covid is a slippery foe, harder to block than polio for example. But the vaxes are well proven to reduce odds of the worst outcomes. Even there, just like our MPNs, there are plenty of exceptions.
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This study in crowded prisons for Omicron is consistent, and it continues to show the value of hybrid immunity (get vaxed even if you've had it already)
" those who received at least one vaccine shot were 24% less likely to infect close contacts... and those who had been both vaccinated and previously infected were 41% less likely to pass on the virus compared with unvaccinated individuals without a previous infection...each vaccine dose a person had reduced the risk of passing on the virus by a further 12%, on average" but the benefit does reduce with time.
nature.com/articles/d41586-...
The journal Vaccine also raises concerns on risk-benefit considerations given the concerning heart injuries observed among the vaccinated. On examination of serious adverse events of the COVID vaccines, these researchers complain that “raw data from the COVID-19 vaccine clinical trials are not publicly available,” and “Unfortunately, as we approach 2 years after release of COVID-19 vaccines, participant level data remain inaccessible.” J Fraiman, J Erviti, et al. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. sciencedirect.com/science/a...
This Professor of Immunology started the Specialism of Immunology in Australia and has a lot to say Re these current range of injections which cannot be denied and are part of any informed consent discussion
oh am I rough after having the moderna!!!
I was ok with the AZ. ( 1st 2) I think I’m worse with this because I carried on with my commitments.
I have had 4 vaccines in total. Three of which were before my PV diagnosis. Both initial and follow up vaccine were Astra Zeneca and the booster was Pfizer.
The fourth 4months ago after Dx was Moderna. I must admit I had no reaction to the AZ, slight reaction to the Pfizer and the worst reaction to Moderna. Saying that it was not that bad, shivering/headache which lasted a day no more.
Everyone reacts differently, I suppose you need to weigh up on the one hand a reaction to the vaccine and if you get Covid how it would be. I have had Covid and it was, for me, like a bad cold whether that was due to vaccines who knows and I know that I was lucky.
I would just love to know if we have built up antibodies with all these vaccines 🤔
I’d had four Pfizer before I got covid. Specialist said to have Pfizer. I still got covid in April this year. I had antibody blood test Before the infusion . I had no antibodies. Hoping I’ve built up a few after having covid. I also had fifth dose a month after the virus. I will defuse the jab if it’s not Pfizer as that’s what was told to have by heamatology .
do you mind telling us why heamo said that?
i get regular antibody tests and all show I still have antibodies in my system. Whether that is related to vaccine, having covid twice or both, who knows.
I don’t have regular tests, didn’t know they done them, but have had two second one said this :-
“Thank you for doing a coronavirus (COVID-19) antibody test.
Antibodies were found in your blood sample. This means it’s likely you’ve had COVID-19 in the last 6 months. We detected antibodies that are made after an infection, and also antibodies that could have been caused by a vaccine.”
Just wonder how long they last.
i am part of ONS covid Research study so thats how I get regular tests.
👍 Mine was done as part of Zoe Covid Study they invited me to take them. Think the government withdrew funding for Zoe few months ago now.
I am thinking along your lines. AZ suited me better. I too have had Covid. Each of the last 3 jabs are like having covid.
it does not stop you getting the virus or passing it on.
Yes I know this but the more antibodies you have the better chance you have of it being milder.
Some members have tested and found very low or no antibodies, UK at least at one time offered these tests. Most do have some. But the less studied effect is on T-cells. These are the long term memories that don't keep the virus out but do prevent it from getting too far in our bodies. Generally T-cell response is good from vaxes and infections.
I have had all of them so far and intend to have the next one next week-I am 77 and have various health problems -I would not miss any of them. If they are a different brand never mind have it anyway. Am having flu vac 2 weeks after.
everyone is different in reactivity.
Currently the moderns spikevax bivalent is being used as boosters as it gives the best protection against the original and omicron variants.
I had mine yesterday and very grateful to the NHS for this.
fwiw I was reactive last time but nothing other than a slight sore arm this morning.
Get protected is my advice.. We are so. lucky to be offered a vaccine.
Is there some current info comparing the Pfizer and Moderna bivalents? It would be neat to see. Moderna does show a stronger reaction here, (reproduced from above in the thread) at 50mcg vs 30 for Pf.
oh I’ve always said I’m no good sympathising with people unless I have some sort of experience of what they are going through. I’m a bit of ‘pick yourself up dust yourself down and get on with life’
BUT I’ve just had covid jab 6 and I’ve had ENOUGH!!
Being stupid I put being really cold at night so no sleep and then having to wear wearing two fleeces all yesterday down to the change in the weather. Being hungry and feeling sick and headachy down to a family upset. Paracetamol did not touch the headache.
The ache in the left of my back I put down to a muscle spasm after yoga. Lol
Later after over 30 hours I managed to eat.
Now approximately 40 hours I’m still very jaded and headachy still don’t want to eat but can manage to get a little down me.
I’ve had covid. I was lucky I was ill for about 5 days only.
I calculate that being ill with each jab has made me ill in total for a lot longer.
After a full recovery I then have to catch up on the household chores.
Along with the fatigue from ET
I’ve had enough!
6 is a very lot of shots, understand your feeling. In the US they are trying a new idea that it will be only once a year like flu since they know people are fed up and confused.
I opted to stop at 3 shots (+ infection) But I will get the new bivalent.
there is now very good research that the incidence of viral infection increases in the those constantly boosting and Professor Clancy has excellent explanations to why that is.
I would only want Pfizer too! I had 4 Pfizer’s and 1 Moderna . Two weeks after the Moderna I caught shingles and still suffering from it. Maybe no connection at all but it has made me wary of any more. I’m feeling very conflicted!
As you can see above, the Moderna shot is quite a bit larger than the Pfizer. So staying with Pfizer might be less risky in your case if you get any more shots
but size of the vaccination is not relevant. an espresso coffee can hold the same amount of caffeine as a latte.
Sorry for confusion. The units 30mcg and 50 mcg are equiv to the "caffeine" it's the actual weight of the active ingredient. There is another unit that is sometimes used mL (volume) that would be the size of the coffee cup. (liquid volume in cc in the syringe) These numbers can be similar which confuses it even more.
To sum: the plot, reproduced here, shows varying doses by weight of active mRNA agent in mcg. It matches a pattern of more effect with increasing active ingredient dose. (the 60mcg was only for this study, Pfz is offered for adults only in 30mcg
mRNAOmicronDualValent
are you saying this graph indicates that the Moderna has a greater efficacy ?
I believe efficacy is the actual effect in preventing or reducing severity of infection (why we take the vax) while the plot here is the antibody response (how the vax provides the protection). They are different, but of course we need an antibody response to get the efficacy.
-They have found a consistent relation between antibody response and protection with covid vaxes, but as with MPNs nothing is ever all simple. The complex but very important long term t-cell immunity is not in most studies including this one.
-Note that the experts are not that impressed with how much extra protection the new bivalents offer, but it is more than without the bivalent part added.
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With all that qualifier, yes, the Moderna offers more protection in this result. Note that getting a double dose of Pfizer at 60 in this plot (if it were possible) provides the highest effect, but it is only avail as 30.
most of those assumptions on less effects from infection have been convincingly been put to bed as the amount of time and observation of continued boosters is beginning to accumulate and have to be balanced against potential long term side effects of the boosters.
I agree evidence points to diminishing returns after a 3rd shot of the same type vax, and even after a 2nd if prior infection. That's why I did not get the 4th, since I had 4 counting my infection. But there is suggestion that a different vax can be of greater help, I would get the Novavax if it were avail as a booster. So I'll get the bivalent since at least there is some difference over the prior vaxes.
Regarding the data in the plot, it was comparing the original mono valent to the bivalent against Omicron. Whether either actually helps as a 4th+ dose is a good question, but it did show the bivalent had improved antibody effect vs Omicron.
Hello HazeBlue, like you, I am a bit apprehensive at the thought of a 6th vaccine in less than 2 years…and our local GP surgery is combining them with the flu vaccine as well. I am hopeful it will be Pfizer as that was the only one which I didn’t have a reaction too, my last one ..Moderna , knocked me out for a month. I have heard it is mostly Moderna though..so not looking forward to it. It would be good if we knew we were actually getting any immunity from all this stuff being pumped into us too !
I think it's better to get the flu and covid shots separately in time in case one of them makes side effects so we can know which one it was to advise our future vax plans.
I think I read somewhere it’s best to wait 2 weeks between covid and flu jab
have just had Covid despite all jabs & booster so will not be having another . Not sure all these jabs are helping with new variants also refused anti viruls as hospital said best to let body deal naturally for immunity . Had it 5 days like a bad cold & no other side effects after . Julia . Exeter .I
Can you get six Covid shots iN the UK? In the US we are only getting our second booster which means a total of four shots.
If you are considered to be immunosuppressed, you get a booster every three months or so, especially if over 70.
didn’t realise our entitlement was every 6 months thank you
I had two AZ and three Pfizers. AZ was okay with me but Pfizer did not like me and I was not feeling well for days. I am not sure what to do since we have no choice of vaccine.
We don't know what it's going to be yet, but it's thought it's likely to be Moderna. Had AZ last time and it was awful in the days following.
Yes, like most here I am nervous and I am not rushing to get my booster this time - but I will have it regardless of what it will be (I think it will be moderna). I've had 5 pfizers. Last one was in April so I am keen to leave a six month gap. So far I have not caught covid despite my 18 year old daughter being really poorly with it (and she had had 3 jabs) in the summer. I am definitely NOT having flu and covid vaccines together. Like Hunter, I had flu and pnumonia vaccines together once and swore never again. I have been a bit sneaky and nipped off to the pharmacy to book my flu vaccine. I will get that one done and then book my covid booster for a couple of weeks later!
Not for me! One booster shot was enough! Somehow I've escaped so far ever coming down with Covid and haven't been as careful as I should be. The first booster shot gave me a horrible reaction so no more shots.
I do it to protect the NHS but really want to know more now that I’ve had 6 jabs
Not getting it.
the 6th jab in North Yorkshire is Moderna Spikevax bivalent Original/Omicron.Had it 12/9/22 no problems
Are you offered cov jab no. 6 already? Family and friends that I know already have enough after the 2nd and 3rd (Pfizer, AZ, Moderna). Some eventually went on to get the 4th just because they're offered and they even didn't know if it gives them immunity. But it's not. They all got covid few times. One friend even got severe pneumonia after the 3rd and hospitalized for 2 weeks. So traumatic that he didn't leave home for more than a month. My husband felt really sick often this year, so strange with symptoms he never felt before (considered always healthy and no health issues). My grandparents are both 85 and 92, didn't take any jabs. They're the healthiest of us all. We're all baffled. They live their life normally, we never do restrictions with family gatherings. I'm worried what these jabs do to our bodies in the future. I also have enough, will not take any.
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