Since I started taking hydroxychloriquine last year I've gained a stone in weight and simply can't lose it. Has anyone else had this problem? And more importantly, have you found a way to lose the weight? Usually I'm good at dieting. I eat healthily and exercise regularly, but just can't shift this weight. I'm the heaviest I've ever been and I hate it. Otherwise I find the hydroxy helpful as I get fewer flare ups and don't feel as completely exhausted as I did before taking it.