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Experiences with
Levodopa
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Doesn’t the Half-Life of C/L apply only to, while in the bloodstream and once Levodopa crosses the BBB it is stored until used?
The
plasma
half-life of
levodopa
is about 50 minutes, without carbidopa. When carbidopa and
levodopa
are administered together, the half-life of
levodopa
is increased to about 1.5 hours. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?
The
plasma
half-life of
levodopa
is about 50 minutes, without carbidopa. When carbidopa and
levodopa
are administered together, the half-life of
levodopa
is increased to about 1.5 hours. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?
Gcf51
in
Cure Parkinson's
27 days ago
Study review highlights limits of levodopa effectiveness
This seems very promising https://parkinsonsnewstoday.com/news/study-review-highlights-limits-
levodopa
-effectiveness/
This seems very promising https://parkinsonsnewstoday.com/news/study-review-highlights-limits-
levodopa
-effectiveness/
Farooqji
in
Cure Parkinson's
4 days ago
Infusion therapy better than pills at reducing Parkinson’s symptoms
For the trial, 381 patients with Parkinson's disease in 16 countries were randomised to receive continuous subcutaneous infusion of
levodopa
, or oral
levodopa
.
For the trial, 381 patients with Parkinson's disease in 16 countries were randomised to receive continuous subcutaneous infusion of
levodopa
, or oral
levodopa
.
Farooqji
in
Cure Parkinson's
4 months ago
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Subcutaneous combination therapy improves ‘good on’ time in Parkinson’s
dyskinesia compared with immediate-release
levodopa
/carbidopa (IR-LD/CD) at week 12.
dyskinesia compared with immediate-release
levodopa
/carbidopa (IR-LD/CD) at week 12.
Farooqji
in
Cure Parkinson's
2 months ago
Amantadine induced muscle spasm/dytonia
I am not sure my muscle spasm/ dystonia is caused by
levodopa
itself or amandatine. anyone has experience?
I am not sure my muscle spasm/ dystonia is caused by
levodopa
itself or amandatine. anyone has experience?
limcheeese22
in
Cure Parkinson's
2 days ago
5 scientists win 2024 SPARK NS awards for Parkinson’s research
Miller, PhD, a professor at Columbia University, will assess how to prevent further damage of dopamine-producing neurons by
levodopa
and its derivatives.
Levodopa
is the precursor of dopamine and a gold standard therapy for Parkinson’s that effectively reduces early motor symptoms.
Miller, PhD, a professor at Columbia University, will assess how to prevent further damage of dopamine-producing neurons by
levodopa
and its derivatives.
Levodopa
is the precursor of dopamine and a gold standard therapy for Parkinson’s that effectively reduces early motor symptoms.
Boscoejean
in
Cure Parkinson's
25 days ago
Case report: Levodopa challenge test is important in identifying dopamine-induced freezing of gait in patient with Parkinson’s disease
female PD patient complicated with dopamine-induced FOG, which was identified during
levodopa
challenge test. Her symptoms were alleviated after adjusting the medication. https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1464152/full#SM1
female PD patient complicated with dopamine-induced FOG, which was identified during
levodopa
challenge test. Her symptoms were alleviated after adjusting the medication. https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1464152/full#SM1
Farooqji
in
Cure Parkinson's
16 days ago
Effect of Early Levodopa Treatment on Mortality in People with Parkinson's Disease
Early
levodopa
initiation in Parkinsons does neither postpone nor accelerate mortality or PD-related complications, nor does it precipitate earlier occurrence of PD-related complications or mortality https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.14174
Early
levodopa
initiation in Parkinsons does neither postpone nor accelerate mortality or PD-related complications, nor does it precipitate earlier occurrence of PD-related complications or mortality https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.14174
Farooqji
in
Cure Parkinson's
2 months ago
punch drunk and off time
Levodopa
meds don’t do much for me, I say that I feel like bad crap on the meds and really bad crap off the meds,. Does anyone else have the punch drunk feeling in off time and/or
levodopa
not really helping a lot?
Levodopa
meds don’t do much for me, I say that I feel like bad crap on the meds and really bad crap off the meds,. Does anyone else have the punch drunk feeling in off time and/or
levodopa
not really helping a lot?
Jmellano
in
Cure Parkinson's
28 days ago
Levodopa only?
My Neurologist told me that he didn't know what else to prescribe me but he would be happy to increase my
Levodopa
dose, even though I have reported to them that I literally could not function on the dose I am or have ever been, and I have been trying to reduce my
Levodopa
intake and not to increase
My Neurologist told me that he didn't know what else to prescribe me but he would be happy to increase my
Levodopa
dose, even though I have reported to them that I literally could not function on the dose I am or have ever been, and I have been trying to reduce my
Levodopa
intake and not to increase
Daisies22
in
Cure Parkinson's
4 months ago
Levodopa Phobia
Key Points 2018 @Nature_NPJ Nature Parkinson's Disease Journal Review by @KRayChaudhuri1 : -
Levodopa
phobia is under-recognized. - The authors cite that there can be 'profound detrimental clinical complications if left to continue.' - Several types of
levodopa
phobia. - 'Fear of
levodopa
-induced
Key Points 2018 @Nature_NPJ Nature Parkinson's Disease Journal Review by @KRayChaudhuri1 : -
Levodopa
phobia is under-recognized. - The authors cite that there can be 'profound detrimental clinical complications if left to continue.' - Several types of
levodopa
phobia. - 'Fear of
levodopa
-induced
Farooqji
in
Cure Parkinson's
5 months ago
Levodopa absorption
What makes absorption of the last (evening)
Levodopa
dose very poor regardless of the last meal taken before, or even on empty stomach?
What makes absorption of the last (evening)
Levodopa
dose very poor regardless of the last meal taken before, or even on empty stomach?
gesundheight
in
Cure Parkinson's
4 months ago
Dyspnea when off
does anybody gets shortness of breath when
levodopa
is wearing off😳😳😳😥😥😥😥
does anybody gets shortness of breath when
levodopa
is wearing off😳😳😳😥😥😥😥
Rupa88
in
Cure Parkinson's
5 months ago
Levocarb side effects
Extreme gait issues which have been treated with higher dosages of
Levodopa
. I am experiencing body pain when I get close to my next dose, which is down to a 3 hour interval. Could the pain be withdrawal as my dosage is usually worn off by then?
Extreme gait issues which have been treated with higher dosages of
Levodopa
. I am experiencing body pain when I get close to my next dose, which is down to a 3 hour interval. Could the pain be withdrawal as my dosage is usually worn off by then?
bullet65
in
Cure Parkinson's
2 days ago
Effective medication for dystonia as first symptom?
Any experience from anyone with
levodopa
, antagonists or mao-b inhibitors as a way to suppress dystonia as preceding PD symptom?
Any experience from anyone with
levodopa
, antagonists or mao-b inhibitors as a way to suppress dystonia as preceding PD symptom?
BlockRuys
in
Cure Parkinson's
3 months ago
levodopa and augmentation
I have also been diagnosed with Parkinson’s disease and prescribed
Levodopa
. Can someone please confirm whether or not this is a dopamine agonist like Pramipexole. If so does it also lead to augmentation?
I have also been diagnosed with Parkinson’s disease and prescribed
Levodopa
. Can someone please confirm whether or not this is a dopamine agonist like Pramipexole. If so does it also lead to augmentation?
Covenant1962
in
Restless Legs Syndrome
3 months ago
question about macuna
If so, i am taking 100mg
levodopa
/25mg benserazide(Madopar) if I want to add 400mg mucuna15%
levodopa
; so I need to take extra benserazide? thx
If so, i am taking 100mg
levodopa
/25mg benserazide(Madopar) if I want to add 400mg mucuna15%
levodopa
; so I need to take extra benserazide? thx
limcheeese22
in
Cure Parkinson's
6 months ago
Too much levodopa?
Other than dyskinesias what clues have people received that tell them that their dosage is too high?
Other than dyskinesias what clues have people received that tell them that their dosage is too high?
puretone
in
Cure Parkinson's
3 months ago
levodopa or not levodopa
So the new young doctor said I should take
Levodopa
and that the dyskinesia caused by
Levodopa
is a myth because nowadays with low dosage this doesn’t happen. I don’t want to take it but my husband insists I should try. It’s my body and I will do whatever I decide is good for me.
So the new young doctor said I should take
Levodopa
and that the dyskinesia caused by
Levodopa
is a myth because nowadays with low dosage this doesn’t happen. I don’t want to take it but my husband insists I should try. It’s my body and I will do whatever I decide is good for me.
LorenzaS
in
Cure Parkinson's
6 months ago
UC study: Subcutaneous infusion pump safe, effective for Parkinson’s treatment
Levodopa
is most commonly administered orally, but this trial tested continuous, 24-hour
levodopa
delivery through a subcutaneous infusion pump.
Levodopa
is most commonly administered orally, but this trial tested continuous, 24-hour
levodopa
delivery through a subcutaneous infusion pump.
Farooqji
in
Cure Parkinson's
6 months ago
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