My wife has had a very low platelet count (between 0-5) for a few months. She was put on Romiplostim injections but they did not have any effect. She was then given a round of Rituximab and following this her platelet count increased to over 200. The Romiplostim injections were halted. Her platelet count has now increased to over 1600. Has anyone else had issued with extremely high platelet count following a very low platelet count.