Borderline Positive lupus anticoagulant, other aps antibodies negative

[Sanjumax]

Had 2 twin pregnancy losses , of which one of the twins in my recent pregnancy which I conceived through ivf ,had turners syndrome, hence terminated. I have been diagnosed with borderline Positive lupus anticoagulant but rest of the antibodies in the panel are negative. I m currently 17 weeks pregnant, on aspirin 75mg and prednisolone 5 mg... Confused whether clexane has to be continued as I took till 12 weeks of gestation.. my immunologist wants me to continue but obstetrician has stopped... I want a healthy baby after this prolonged struggle and pain of losing 4 babies (2 pairs of twins).. kindly give advise according to your experience

[Sanjumax]

Thank you, I m from India, I have also been started on hydroxychloroquine 200 mg once a day but due to opposing views of the immunologist and obgyn , I have stopped for past 4 weeks... My DRVVTor LA screen to confirm ratio being 1.22 and the positive result reference range is 1.2, so it's like borderline Positive, hence being in the grey zone confused... But if you could out of experience if the pregnancy outcome significantly improves I will restart clexane... I m really grateful for the concern from your end

[Sanjumax]

No i dont have any symptoms of aps, my first pregnancy, both the fetuses showed delayed development, saw heartbeat only in 10 weeks which was already in bradycardia range and lost them spontaneously by 11 weeks.

I was not tested for aps in first but i couldn't conceive for next 2 yrs, then was evaluated which showed among aps antibodies only lupus anticoagulant was 1.3 , then started on medications... i underwent ivf in march 2017 which was twins and contd LMW heparin, hydroxycloroquine, aspirin but i lost first twin at 6 wks, and second i terminated as it was Turner's syndrome with generalised edema, ie hydrops.. later conceived naturally in july this year and now till date scans looks alright but repeat lupus anticoagulant at 6 wks of this preg is 1.1, n repeat at 17 wks is 1.22.. so confusion arises if to continue LMW heparin as my gynaec feels its not required

[Sanjumax]

Yes i m still in india.. of the three aps testing done firstvtime positive and next it was negative and these were from same labs... recent testbrepeated in a good standardised lab is just 0.2 uniits more than normal value

[Lure2 in reply to Sanjumax]

I can tell you that some of us have sometimes negative antibodies but still symptoms. Others have always positive antibodies.

That is why we need a Specialist who understands these issues.

Usually the anticoagulation should never be stopped if we have HS/APS. Please tell your Doctor about this.

Best wishes from Kerstin in Stockholm

[Sanjumax]

Sure, thank you, that would be helpful