I just spotted this article; it doesn't mention Hughes Syndrome or Lupus specifically, but does talk of autoimmunity in general:
"An Irish mathematician has helped crack complex codes about our immune system which may ultimately lead to better treatments for Crohn's, coeliac disease, diabetes and rheumatoid arthritis."
"The team's ultimate aim is to help design new therapies for auto-immune diseases and improved vaccines and also take what they have learnt so far and use it to explore how immune systems can resist bacteria and viruses."