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Almost ready for phase 1: JHU083 (or JHU-083) a selective glutamine metabolism blocker
Specifically, JHU083 can only be turned into its active,
glutamine
-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that PCa is
glutamine
dependent but that
glutamine
is super useful in many biological processes inside our body, so
Specifically, JHU083 can only be turned into its active,
glutamine
-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that PCa is
glutamine
dependent but that
glutamine
is super useful in many biological processes inside our body, so
Maxone73
in
Advanced Prostate Cancer
4 months ago
Will Androgen-nourished Prostate Cancer Cells Succumb to "Glucose/Glutamine Starvation"?
If prostate cancer cells are enriched with androgens that normally propel their growth and spread, could they still be "starved" by selectively inhibiting their GLUT receptor expressions to block their uptake of glucose and also by limiting their ability to turn to and utilize
glutamine
as a backup
If prostate cancer cells are enriched with androgens that normally propel their growth and spread, could they still be "starved" by selectively inhibiting their GLUT receptor expressions to block their uptake of glucose and also by limiting their ability to turn to and utilize
glutamine
as a backup
back2health
in
Advanced Prostate Cancer
4 months ago
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
This subgroup presents an intriguing opportunity for targeted therapy focusing on
glutamine
metabolism.
This subgroup presents an intriguing opportunity for targeted therapy focusing on
glutamine
metabolism.
God_Loves_Me
in
Advanced Prostate Cancer
4 months ago
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L Glutamine
Hi everyone, could anyone advice me on L
Glutamine
, I have Intestinal Metaplasia and I don't know if I should take it. I have read it supports the stomach lining but I am concerned that this would only help a 'normal stomach' and I may do more harm than good. Thanks
Hi everyone, could anyone advice me on L
Glutamine
, I have Intestinal Metaplasia and I don't know if I should take it. I have read it supports the stomach lining but I am concerned that this would only help a 'normal stomach' and I may do more harm than good. Thanks
Helliborous
in
Pernicious Anaemia Society
7 months ago
Zinc L- Carnisone with L- Glutamine
Hi everyone, have any of you tried the above marketed as THERA NORDIC REZCUE. It is supposed to be benificial in healing inflammation in the digestive tract. Your comments would be welcome , thanks
Hi everyone, have any of you tried the above marketed as THERA NORDIC REZCUE. It is supposed to be benificial in healing inflammation in the digestive tract. Your comments would be welcome , thanks
Helliborous
in
Pernicious Anaemia Society
6 months ago
Glutamine
Hey, has anyone any experience using
glutamine
for Atrophic Gastritis
Hey, has anyone any experience using
glutamine
for Atrophic Gastritis
Helliborous
in
Pernicious Anaemia Society
10 months ago
Bloating
I've decreased probiotics to 1 per day and am still taking Zinc, Iron tablets, Akkermancia, L
Glutamine
and the fibre. (1 teaspoon of milled flax/chia in my breakfast porridge around 08:30).
I've decreased probiotics to 1 per day and am still taking Zinc, Iron tablets, Akkermancia, L
Glutamine
and the fibre. (1 teaspoon of milled flax/chia in my breakfast porridge around 08:30).
Sardinesagain
in
IBS Network
7 months ago
Are Functional Motor Symptoms Influenced by Glutamate and Glutamine Fluctuations?
I was reading an old post and someone commented about this, so naturally I asked the question and found this study: https://www.neurologylive.com/view/functional-motor-symptoms-influenced-glutamate-
glutamine
-fluctuations Interesting reading and saying that the "functional movements" are down to biology
I was reading an old post and someone commented about this, so naturally I asked the question and found this study: https://www.neurologylive.com/view/functional-motor-symptoms-influenced-glutamate-
glutamine
-fluctuations Interesting reading and saying that the "functional movements" are down to biology
Lady4
in
Functional Neurological Disorder - FND Hope
8 months ago
L glutamine benefits ?
Hi everyone, I am thinking of ordering some of above but not sure if taking it is safe as I have AMAG with neuroendocrine hyperplasia can anyone offer any advice please.
Hi everyone, I am thinking of ordering some of above but not sure if taking it is safe as I have AMAG with neuroendocrine hyperplasia can anyone offer any advice please.
Helliborous
in
Pernicious Anaemia Society
9 months ago
confused about supplements and certain foods
I take creatine would like to add bcaa/lucene and
glutamine
. Any issues here? Also I tend to consume a reasonable amount of Greek yogurt, mostly low-fat, and I add feta cheese to my salads and vegetables for lunch. Is dairy an issue?
I take creatine would like to add bcaa/lucene and
glutamine
. Any issues here? Also I tend to consume a reasonable amount of Greek yogurt, mostly low-fat, and I add feta cheese to my salads and vegetables for lunch. Is dairy an issue?
SierraSix
in
Advanced Prostate Cancer
1 year ago
Supplement Guidance
Now my nutritionist wants me to start taking Slippery Elm and
Glutamine
3 x a day but if have found that she has prescribed quite a lot that doesn’t agree with me. Originally it was 7 different things but 2 didn’t agree with me and are just sat in the cupboard and they weren’t cheap!
Now my nutritionist wants me to start taking Slippery Elm and
Glutamine
3 x a day but if have found that she has prescribed quite a lot that doesn’t agree with me. Originally it was 7 different things but 2 didn’t agree with me and are just sat in the cupboard and they weren’t cheap!
Kimsy17
in
IBS Network
9 months ago
The steroid with zytiga can be a deal
My Dads new oncologist switched his steroid from prednisolone to dexamethasone - she was distressed at first appointment to see he was on zytiga and prednisolone. She said research pretty clear that dexamethasone is better. On today's PSA results she is clearly correct. We thought that he had become
My Dads new oncologist switched his steroid from prednisolone to dexamethasone - she was distressed at first appointment to see he was on zytiga and prednisolone. She said research pretty clear that dexamethasone is better. On today's PSA results she is clearly correct. We thought that he had become
TomsD1
in
Advanced Prostate Cancer
1 month ago
Antiandrogen Withdrawal Syndrome After Stopping Enzalutamide in Metastatic Castration-Resistant Prostate Cancer: Two Case Reports & Review
https://www.cureus.com/articles/267994-antiandrogen-withdrawal-syndrome-after-discontinuation-of-enzalutamide-in-patients-with-metastatic-castration-resistant-prostate-cancer-a-report-of-two-clinical-cases-and-a-literature-review#!/ Abstract Metastatic prostate cancer treatment is based on
https://www.cureus.com/articles/267994-antiandrogen-withdrawal-syndrome-after-discontinuation-of-enzalutamide-in-patients-with-metastatic-castration-resistant-prostate-cancer-a-report-of-two-clinical-cases-and-a-literature-review#!/ Abstract Metastatic prostate cancer treatment is based on
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Levo up, T3 down
Also I am taking vit D+K, B complex, Magnesium, Zinc,Fish Oil, L-
Glutamine
All help gratefully received
Also I am taking vit D+K, B complex, Magnesium, Zinc,Fish Oil, L-
Glutamine
All help gratefully received
StanleyThyroid
in
Thyroid UK
5 months ago
Glutamine and RLS Does anyone have any info please?
Now they said to take
Glutamine
for the neuropathy and it did help but low and behold the RLS came back. I read a little bit that it might be from the
Glutamine
? And possibly NAC - N acetyl cysteine might help? Does anyone have any experience with either
Glutamine
or NAC?
Now they said to take
Glutamine
for the neuropathy and it did help but low and behold the RLS came back. I read a little bit that it might be from the
Glutamine
? And possibly NAC - N acetyl cysteine might help? Does anyone have any experience with either
Glutamine
or NAC?
charlottesgrandmom
in
Restless Legs Syndrome
1 year ago
Targeting Glutamine Metabolism
As a building block of protein, one would need to avoid fully-formed protein when attempting a
glutamine
-restrictive diet, but it is plentiful in other foods too [3]: The following are the percentages of protein made up of L-
glutamine
in each high-
glutamine
food: Eggs: 4.4% (0.6 g per 100 g of eggs
As a building block of protein, one would need to avoid fully-formed protein when attempting a
glutamine
-restrictive diet, but it is plentiful in other foods too [3]: The following are the percentages of protein made up of L-
glutamine
in each high-
glutamine
food: Eggs: 4.4% (0.6 g per 100 g of eggs
pjoshea13
in
Fight Prostate Cancer
1 year ago
RLS amino acids
I take
Glutamine
, Ornithine and Lyseine. If anyone tries this please let me know how it goes. I have never heard of anyone else using it for restless legs and I can't remember what I was taking it for. I would be really happy if it helped someone else. Tricia C
I take
Glutamine
, Ornithine and Lyseine. If anyone tries this please let me know how it goes. I have never heard of anyone else using it for restless legs and I can't remember what I was taking it for. I would be really happy if it helped someone else. Tricia C
1jeremiah1
in
Restless Legs Syndrome
1 year ago
L-Glutamine
If I take L-
Glutamine
my joints don't hurt, my energy is up, I sleep peacefully all night (with usual pee breaks). How can it be bad for me if it makes me feel so well?
If I take L-
Glutamine
my joints don't hurt, my energy is up, I sleep peacefully all night (with usual pee breaks). How can it be bad for me if it makes me feel so well?
gaija
in
Kidney Disease
1 year ago
Anxiety/depersonalization triggered by L-Glutamine?
So, the episode started three weeks ago, around 1 hour after taking l-
glutamine
. Had taken it for two (one month on, one month off, then one month on again until I felt like this) months (1g per training day, didn’t take over the weekends).
So, the episode started three weeks ago, around 1 hour after taking l-
glutamine
. Had taken it for two (one month on, one month off, then one month on again until I felt like this) months (1g per training day, didn’t take over the weekends).
JoshuaBrownie
in
Anxiety and Depression Support
1 year ago
When shall I start 10K ??
I take (under the guidance of a dietitian) 1 probiotic, 2 digestive enzymes, 2 L-
glutamine
, Vitamin C, D and zinc, Evening Primrose oil (all these mentioned are natural) and 30mg Amitriptyline (for IBS pain management) - all these tablets are mainly to control my IBS.
I take (under the guidance of a dietitian) 1 probiotic, 2 digestive enzymes, 2 L-
glutamine
, Vitamin C, D and zinc, Evening Primrose oil (all these mentioned are natural) and 30mg Amitriptyline (for IBS pain management) - all these tablets are mainly to control my IBS.
adnewg73
in
Bridge to 10K
7 months ago
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