Will Androgen-nourished Prostate Cancer Cells Succumb to "Glucose/Glutamine Starvation"?

[back2health]

If prostate cancer cells are enriched with androgens that normally propel their growth and spread, could they still be "starved" by selectively inhibiting their GLUT receptor expressions to block their uptake of glucose and also by limiting their ability to turn to and utilize glutamine as a backup food source?

[Cebubob]

mdpi.com/2072-6694/12/1/154

Been asking myself the same question. Some research findings.

[Maxone73 in reply to Cebubob]

Interesting but not even preclinical, tested on cell lines, which means 1-3% chance to work on humans.

[Maxone73]

one of the articles I have posted recently talks about an experimental selective glutamine inhibitor. They can only be selective because otherwise, if you block it completely, you are simply killing yourself because glutamine is used in many important chemical reactions within our body. So they are aiming at inhibit it only in cancer cells. Same goes for glucose, you cannot deplete it completely if you want to stay alive (plus cancers adapt themselves to produce glucose from many different sources).

[back2health in reply to Maxone73]

Please, this is not an answer to my question. My question is not about the "selectivity of glutamine inhibitors." I already realize that they have to be "selective" to avoid starving healthy cells as well.

The question isn't about this. Rather it's about whether or not "androgen-nourished prostate cancer cell will succumb to glucose/glutamine starvation?"

[Maxone73 in reply to back2health]

I was simply adding that they are already investigating the issue. The answer you are looking for can come just from such experiments, not from speculation. That’s all. Sorry for invading your thread, good luck!