Ok, I have been reviewing my notes and I must say that, even if it's still a phase 1 trial, I like JANX007.
JANX007 focuses on PSMA, delivering immune cells directly to cancer cells while avoiding healthy tissue. This precision minimizes side effects and maximizes the attack on cancer.
To further improve safety, JANX007 uses a "masking" technology. This keeps the drug inactive until it reaches the tumor, reducing the risk of triggering unnecessary immune reactions in the rest of the body.
This is the theory, but in practical terms:
- in 16 patients treated with the drug (in November 2024, but they are still recruiting), every single one saw at least a 50% drop in PSA,, which means activity in 100% of the population
- over 60% of these patients experienced a PSA drop of 90% or more (a darn deep response in a heavily pre-treated population, not easy to achieve)
- side effects have been mild, showing that the drug is not only effective but also safe (which confirms that both their masking technology and immune cells delivery work well)
- it's being tested as mono therapy, which leaves plenty of space for a combined therapy (immune checkpoint inhibitors come to my mind).
If larger trials confirm these results, JANX007 could become a key treatment, a real game changer for advanced prostate cancer. And their masking technology is very interesting as it's an example of very targeted delivery.
JANX007 is still in early testing, yes, so fingers crossed and eyes opened 😜😜
Tomorrow, I’ll have another PET scan, and I could really use some positive thoughts. Thinking about JANX007 has helped me relax a little. As many of you know, these tests can bring a lot of stress. Well, I can’t speak for everyone, but for me… they definitely do! 😂😂
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Maxone73
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Good luck on the scan, Maxone73. Praying for you! Appreciate all you do! Targeted therapies sound fantastic and I hope they are all polished up and ready for us very, very soon.
Good luck with the scan Max, sending positive thoughts and good wishes for a good result.
I have my first PSMA pet scan & bone scans coming up at end of month, and am trying to relocate my anxiety into a focus on the positive advances we’re seeing all around us.
JANX007 is sounding very promising isn’t it, and with a suitably assassin like name.
All the best with your scan tomorrow! I look at my scans and say it is what it is and i have time and knowledge that i can find ( dreaded word on other group “research”) a solution whether through trials or MY best option of SOC via my OC. We just need a little more time!
Very good treatment! Lets get this fast tracked FDA!
A protease-activated, masked T-cell engager (TCE) composed of a prostate-specific membrane antigen (PSMA)-binding domain and a CD3-binding domain conjugated, via a tumor protease-cleavable linker, to a peptide mask that prevents CD3 engagement on T-cells and an albumin-binding domain that extends circulating half-life, with potential immunomodulating and antineoplastic activities. Upon intravenous administration of anti-PSMA/CD3 protease-activated TCE JANX007, the tumor protease-cleavable linker is proteolytically cleaved in the tumor microenvironment (TME), which separates the active PSMA-targeted TCE from the peptide mask and the albumin-binding domain. The PSMA-binding domain targets and binds to PSMA expressed on tumor cells. The CD3-binding domain targets and binds to T-cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against PSMA-expressing tumor cells in the TME. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors. The peptide mask allows specific activation of JANX007 in the TME, thereby minimizing systemic toxicity and increasing efficacy.
good luck. I have another PSMA scan next Monday as my psa is climbing even though feel good. Always a nervous time for sure. JANX007 sounds very promising
This trial would not be recommended for PC that doesn’t emit much PSMA would it? My husband had All clear PSMA scans and when they finally did a CAT scan it had progressed into his lymph system. ?????
Hi. It binds to psma and cd3 but I would look into 67Cu bombesin or bisfap, I have written an article about them. If you can't find it using the search bar I will look for it later.
that is quite an intricate targeted mechanism for secret agent and assassin JANX 007. May it be so! Good luck with your scans. Whatever results will guide you.
I will know in one week, but they had a 2 seconds blackout while I was in the machine, so they wanted to repeat part of the scan. So for now I only know it took longer than usual. Bloodwork is fine, everything good, psa stable at 0.01
PET scan confirmed a very slightly better situation compared to last June (in June it was way better than the previous one in December, which was better than the previous one...and on and on...).
But substantially stable disease, that goes in line with my 0.01 PSA. Not bad, I had this last PET scan exactly one year after my last chemo.
I was hoping for a miracle but I am enjoying stable disease as well!
Yes! It's just that sometimes I hope for miracles. I tend to forget how serious my disease is, and these things get me back on planet earth! But I never give up. The next one will be even better!
I’m very similar… I have my first pet PSMA coming up… and hoping, somehow, that it shows NED… or much reduction. Never give up, never stop working at it, always keep hope in our hearts… something that looks like a cure, or very durable remission will be coming!
I’m currently 1 of 12 in this trial at Yale and this is by far the hardest thing I’ve ever put myself through. Unless I’m an outlier, which Is possible, the side effects landed me in the ICU after first dose with cytokine storm. I thought this was it for me. I almost bailed but had serious ptsd going back.
Talk to someone who has gone through this before deciding. It has been brutal for me, but the results my be worth it if it keeps trending at -25psa a day.
I will create my own post to document my entire experience so far.
Been banned from Advanced Prostate Cancer community so I am replying here. It really looks like a rough treatment for you, but I am hoping that your super reaction will get you to super results! I will be 52 next week, it's good to have some first hand info by someone close to my age!
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