Pick of the Month: JANX007, why?

[Maxone73]

Ok, I have been reviewing my notes and I must say that, even if it's still a phase 1 trial, I like JANX007.

JANX007 focuses on PSMA, delivering immune cells directly to cancer cells while avoiding healthy tissue. This precision minimizes side effects and maximizes the attack on cancer.

To further improve safety, JANX007 uses a "masking" technology. This keeps the drug inactive until it reaches the tumor, reducing the risk of triggering unnecessary immune reactions in the rest of the body.

This is the theory, but in practical terms:

- in 16 patients treated with the drug (in November 2024, but they are still recruiting), every single one saw at least a 50% drop in PSA,, which means activity in 100% of the population

- over 60% of these patients experienced a PSA drop of 90% or more (a darn deep response in a heavily pre-treated population, not easy to achieve)

- side effects have been mild, showing that the drug is not only effective but also safe (which confirms that both their masking technology and immune cells delivery work well)

- it's being tested as mono therapy, which leaves plenty of space for a combined therapy (immune checkpoint inhibitors come to my mind).

If larger trials confirm these results, JANX007 could become a key treatment, a real game changer for advanced prostate cancer. And their masking technology is very interesting as it's an example of very targeted delivery.

JANX007 is still in early testing, yes, so fingers crossed and eyes opened 😜😜

Tomorrow, I’ll have another PET scan, and I could really use some positive thoughts. Thinking about JANX007 has helped me relax a little. As many of you know, these tests can bring a lot of stress. Well, I can’t speak for everyone, but for me… they definitely do! 😂😂

[4tunate1]

Good luck on the scan, Maxone73. Praying for you! Appreciate all you do! Targeted therapies sound fantastic and I hope they are all polished up and ready for us very, very soon.

[Maxone73 in reply to 4tunate1]

Thanks a lot! 🥰

[Broccoli24]

Good luck with the scan Max, sending positive thoughts and good wishes for a good result.

I have my first PSMA pet scan & bone scans coming up at end of month, and am trying to relocate my anxiety into a focus on the positive advances we’re seeing all around us.

JANX007 is sounding very promising isn’t it, and with a suitably assassin like name.

[Maxone73 in reply to Broccoli24]

Yess!! Agent janx 007!

[KocoPr]

All the best with your scan tomorrow! I look at my scans and say it is what it is and i have time and knowledge that i can find ( dreaded word on other group “research”) a solution whether through trials or MY best option of SOC via my OC. We just need a little more time!

Very good treatment! Lets get this fast tracked FDA!

Anti-PSMA/CD3 Protease-activated T-cell Engager JANX007

A protease-activated, masked T-cell engager (TCE) composed of a prostate-specific membrane antigen (PSMA)-binding domain and a CD3-binding domain conjugated, via a tumor protease-cleavable linker, to a peptide mask that prevents CD3 engagement on T-cells and an albumin-binding domain that extends circulating half-life, with potential immunomodulating and antineoplastic activities. Upon intravenous administration of anti-PSMA/CD3 protease-activated TCE JANX007, the tumor protease-cleavable linker is proteolytically cleaved in the tumor microenvironment (TME), which separates the active PSMA-targeted TCE from the peptide mask and the albumin-binding domain. The PSMA-binding domain targets and binds to PSMA expressed on tumor cells. The CD3-binding domain targets and binds to T-cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against PSMA-expressing tumor cells in the TME. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors. The peptide mask allows specific activation of JANX007 in the TME, thereby minimizing systemic toxicity and increasing efficacy.

[Maxone73 in reply to KocoPr]

Thanks!

[GardenReno]

good luck. I have another PSMA scan next Monday as my psa is climbing even though feel good. Always a nervous time for sure. JANX007 sounds very promising

[Maxone73 in reply to GardenReno]

Good luck to you as well! Good luck to us all!

[Scout4answers]

Good luck with your scan, be well.

[Maxone73 in reply to Scout4answers]

Thanks!

[Orange95]

Good luck with scan. Thank you for your posts!

[Soumen79]

Hi Max, best of luck, yes each test brings such anxiety, unthinkable

[Soumen79]

I hope this janx007 is found to be repeatedly usable and make this disease chronic

[JolleySprings]

This trial would not be recommended for PC that doesn’t emit much PSMA would it? My husband had All clear PSMA scans and when they finally did a CAT scan it had progressed into his lymph system. ?????

[Maxone73 in reply to JolleySprings]

Hi. It binds to psma and cd3 but I would look into 67Cu bombesin or bisfap, I have written an article about them. If you can't find it using the search bar I will look for it later.