Happy to share my latest progress report. Note that I am mHSPC, lymph nodes only to pelvis and abdomen. I have been on long-cycle modified BAT for 2.5 years now. 3 months of very high testosterone (400mg T-cypionate every 2 weeks), then one month of ADT using Orgovyx. My PSA has continued to decline on this regimen. It was down by 90% in January 2023 to 0.030. Now it has become undetectable <0.015. These were measured at towards the end of the ADT month of each cycle. So my next step will be to measure it during the high testosterone phases.
This provides a convincing example that, contrary to the "conventional thinking" that BAT is only appropriate for metastatic castrate resistant (mCRPC). That indeed it can be effective in controlling Hormone Sensitive PC. Perhaps even more so? I hope there will be a clinical trial for it soon. (Dr. Michael Schweizer? Denmeade? Anyone?)
However, my treatment also included an aggressive radiation treatment, which no doubt also contribute to the excellent response so far. That was SBRT to my oligometastatic nodes followed by molecular targeting radioligand treatments using the experimental monoclonal antibody ligand for Lu177: Lu-PSMA-J591 from GenesisCare in Perth Australia. Two infusions given one month after the SBRT.
Sending profound gratitude to all of my physicians and care teams for supporting me in my non SOC approaches. And to all of you, my friends and supporters on these forums. MateoBeach / Paul
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Absolutely awesome news!!! Bravo, Bravo... Keep at it, and I hope your case may be a shinning example for others to be encouraged not to fear the unknown and individualize their care!
Congrats to the man with the plan! Your results speak for themselves and reflect your careful planning and superb execution. Maybe an n=1 outlier, but more likely a very brave treatment pioneer. There will be lots to discuss this fall in NE. Be Safe and Well until then.
You are indeed the man with the plan...Congratulations 🎊.... The treatment paradigm is evolving... People with vision are changing it... I believe it is only a matter of time ( and not much ) till your n=1 may become an NIH clinical trial. I think you are right, and it is time to monitor USPSA during high T.
May your healing path continue to be successful...
IndiaMart is an unrestricted marketplace. Posting there can get you swamped with offers. Difficult to sort out. Last year Orgovyx generics were not there, but now I see there are. Two India brand names for generic relugolix are Rexilo 120 and Relupros 120. You could try doing searches for those specifically. Let me know if you succeed. I will need some next year for my BAT regimen. Also darolutamide.
I talked to my MO yesterday. She said that daro studies are underway and that FDA expanded approvals are coming. By the way, if you can prove CRPC and your mets are clear, you should qualify.
I have enough Darolutamide at my present usage of half normal doses for two weeks during each of my castrate months of my BAT program. Just one month after 3 months of SPT. Hoping it will be approved in mHSPC before I run out. Paul
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BAT in the UK: does if officially exist
another undetectable 
Rising PSA following Radiation
