Has anyone had Chilli recommended (as a treatment to deplete Substance P)? google it!! I've heard alot about FM sufferers having 3 times normal Substance P, hence tenderness. But this Dr said rubbing it on depletes Sub P. Chilli contains Capsaicin, ingredient in anti-inflamatories. Remember to wash your hands, and don't touch eyes or other sensitive areas.. Will try it out and let you know.