I’m looking for any suggestions to coming off duloxetine after 10years+ and if anything helped these awful and debilitating symptoms I’m having. I’ve gradually reduced from 60mg since last May 2022, currently on 20 mg every 3 days and desperate to stop taking them as I’m this close but I feel so awful! Nausea, shivery, headaches, etc. seeing GP next week but wanting to hear if anyone has had this and anything that helped them?
thank you xx
Duloxetine is a horrible drug. I was only on them for a short period of time maybe a year but the withdrawals were horrendous even when only slightly dropping the dosage, as you say shivers nauseous headaches.
I ended up going cold turkey in the end as I thought well I’m feeling like this on a small reduction so I may as well just stop altogether. I did and it took a while to get over it but the main symptoms stopped after a few days.
No medication should be stopped cold turkey - take advise from your GP please.
That was just my way of dealing with it as I didn’t want to continue like that for months on end.
It is the worst drug I have ever had and I always try to deter people from taking it if possible because of the addiction.
Good luck and I hope you get there okay.
Hello! I'm new here, I have just been diagnosed with Fibromyalgia after 7 years of symptoms from the age of 23. My Rheumatology consultant has suggested I begin taking Duloxetine, but now I'm a tad bit terrified 😂 Is it really terrible? I have been on Gabapentin and Pregabalin in the past, with unfavorable results, they messed terribly with my mental health and made me a miserable mess. I would rather not go through that again. Any experience you have with it would be a great help. Thank you ☺️
I’ve taken Gabapentin and Pregabalin previously and didn’t like them. I’m now on duloxetine 120mg daily. My main problem is having a really dry mouth but found a great mouth spray that I use regularly to help with that. It’s all just trial and error I guess x good luck
Thank you so much for your reply. I will keep the spray in mind when I try them 😊
What mouth spray? That has been my issue as well...
It’s called Oralieve dry mouth relief spray. You can use Xylimelts tablets too (they stick to the gum and gradually dissolve, releasing a small amount of minty liquid into the mouth.) I use these for bedtime as they stay put on the side of the gum. I bought them both from Amazon and I couldn’t be without them x
Thank you so so much! I will check these out!
aww no problem. X good luck 😉
Hi, apologies I didn’t mean to frighten you but I was just sharing my experience of it. Everyone responds differently to medication. A lot of people say that they do get a lot of relief from Duloxetine and so did I but it was the withdrawal when trying to come off them.
I would never go on it again.
Thank you for your response and for sharing your experience! I will try to take precautions when/if I come off them, now I know that it is rather unpleasant. Thank you so much 😊
Hi thank you for replying to my post, and well done for coming off these things.. I just want this withdrawal over with it’s so awful. I’d never go on them again! My GP is monitoring everything. Did you take anything else after stopping duloxetine?
Hi, my consultant put me on methotrexate after that which basically helped all the other meds I am on.
Zapain, tramadol, naproxen, folic acid, biological therapy injections.
I do have other conditions though.
Spondylitis arthritis in my spine degenerative disc disease.
I have a discectomy and fusion in my spine last year (January) and will possibly have to have another one quite soon as the next disc down has gone now.
I have started taking magnesium tablets this year so I’m hoping they will ease the pain a little (but not as yet)
I have tried gabapentin and pregabalin both worked for a while but then made no difference as my body just got used to them so my consultant took me off them.
Hope you get sorted soon, best wishes.
hi Gemimafibro, I just joined yesterday, so a newbie too. I’ve been up to 60mg of Duloxetine but been on that for about 5 years, was on 40mg before that for 4 years +. I tried Pregab & Gabapentin but couldn’t get on with them at all. I think Duloxetine really helped me, for depression and pain, but having been on it soooo long and now struggling with my mental health , my GP wants me to try to come off them as we don’t think they are working for me now after so long. I would try to do more research into them if I was at the beginning of my journey, especially taking a larger dose. If I’d missed taking one dose in the past I certainly knew about it, so it should have given me a heads up of what was to come if I came off them in the future. It’s a huge struggle for me at the moment, the withdrawal is quite debilitating.
Remember tho, that everyone is different, everyone’s reaction the meds or coming off them will be different.
I wish you luck with it all xx
I'm so sorry that your having a horrendous time coming off Duloxetine, I can only imagine the strain on your body and mind 😞. I hope you are able to find something that gives you relief. Thank you for sharing your experience, I really appreciate it ❤️
my oh took 1 capsule it was supposed to help his migraines, the lowest does and some hours later was stuck in small room with what usually happens with eating gluten, has declined to take any more. banana a day seems to helped him more.
for my fibro am on paracetamol, (was on meptid as well however i decided to drop that) and a magnet bracelet. gluten dairy free diet i.e almond milk, and no yeast.
everyone reacts differently to meds,
my only suggestion is never to start a new med on a weekend or late at night to allow any side effects to happen in normal working hours..
Everyone reacts differently to each drug. You have to weigh up the pros and cons. I couldn't take strong painkillers so Duloxetine had to be worth a try, start on a low dose, I'm on 20mgs twice a day and that's all I need plus paracetamol. I'm going to cut down to one a day in the spring if I'm still this good. I'm 67years old so if I have to stay on them for the rest of my life I decided it won't be a problem as I just want to have a life😁
I have Fibromyalgia and Cervical Spondylosis with osteophytes catching the exit root nerves at C5/6/7 so get terrible pain down my arms. I was on Tramadol & Pregabalin and felt so spaced out I was walking like I was drunk half the time.
I had 3 cervical nerve root blocks with diminishing effect, I had cervical traction which helped for a while. I went to an Opiate withdrawal workshop and gradually came off Tramadol and had the Pregabalin changed to Gabapention with Co- Codamol PRN, it worked okay for a while, then when my neck got worse and surgery was not an option the consultant recommended Duloxetine 60mg one a day. Last year the dose was increased to 80mg daily in split 40mg dose morning and night which works well for me.
On the rare occasion that I have gone out and forgotten my meds I certainly know about it later in the day. The pain increases and I get what I can only describe as low grade electric current down my arms, and I feel cold/tired from the pain no nausea or anything. There is no easy answer with pain meds as it depends on the person the condition(s) and what other meds they are on as to whether they will work or react to one another its basically trial and error and you need to read meds instruction leaflet which describe known side effects/interactions and report anything unusual to your GP or if you can't get an appointment to your Pharmacist who will liaise with GP.
I guess its whatever works for you.
Thank you for your reply. I thought I'd given an update. I have been on Duloxetine 60mg for a month, but unfortunately I will be coming off them over the next week. Taking them has brought to the attention of my GP that I seem to have an undiagnosed heart condition. Over the month I had been having heart palpitations that have been getting steadily worse so I visited my GP and found that my resting pulse was 140. He flew into a whoosh of action, calling all the nurses in the surgery to get an emergency EKG done. Which she did over and over, it seemed like she couldn't believe the results because I appeared fine and honestly I felt fine. So their reactions did cause a bit of panic in me. I will be having a 24 hour monitor in the future and have been put on a beta-blocker. This has brought my heart rate down to 89 after just three days and I have normal coloured hands, which have been blue my entire life. It's much better than it was, but still a bit high. I was told to stop the Duloxetine immediately, but after reading others experiences of coming off them I have chosen to take 30mg for seven days and then stop. I'm struggling with my Fibro as it is and a withdrawal might send me over the edge. Thankfully.. I think thankfully 😂.. I was experiencing worse pain whilst on the Duloxetine so I'd have requested to stop anyway. Again, thank you for your reply. It's very helpful to read other people's experiences as I have only just been diagnosed with Fibromyalgia after seven years of symptoms from the age of 23.
Hi lovely, please be careful if you go cold turkey on the duloxeltine, it can cause worse withdrawl symptoms...mine did and now im on a slow taper as i cant cope with the nausea etc. please take care xx
Thank you for your reply and concern 🥰 I have chosen to take 7 days of 30mg that I had spare because of a mess up at my pharmacy, from my regular dose of 60mg once daily. My GP told me to just stop them, I suppose he was worried about me having a heart attack. But after reading others experiences with withdrawing from them I didn't want to put myself through that. I feel a bit weird, a little flu like, on day 2 of the taper, but currently I'm managing. I will try to take it easy next week when I come off them completely though. I appreciate you informing me xx
yes, i understand the heart implications, rest and hydrate, i just have come to realise that our gps just dont understand the withdrawl of drugs like these, and im lucky mine understand now that its not a quick thing. please keep us up to date lovely xx
OMG, its just as well the duloxetine has brought the heart condition to the attention of GP, its probably been something lying dormant since you were young and luckily for you your GP has been on the ball. I hope he is going to investigate further and not just put it down to duloxetine as a sole cause. Hopefully you'll find something more suitable for you.