feeling lost - 2nd FET failure

[Cooperlane450]

Hi ladies,

I’ve just had my negative result from my 2nd frozen transfer and I feel so numb. Im an ‘unexplained infertility’ girl, has anyone else after a second failed transfer thought to themselves that there has to be more as to why this isn’t working?

I had 30 eggs retrieved, but over 60% were not mature so ended up with 3 embryos, 1 A and 2 C’s. I have 1 C left, and if that doesn’t work I’m pretty terrified at the thought of another egg collection. Last time they told my eggs were not the best looking 💔

The last 2 cycles I’ve been on cyclogest 3x a day and the oestrogen patches every other. Does anyone have anything they asked after a second cycle for protocol change or further tests they would recommend?

I just feel so sad and hopeless. I had to go on a course about resilience and I thought to myself this is ridiculous I am resilient I’m doing IVF! But I’m starting to feel a bit defeated.

Sending love to anyone else going through this gruelling process xxx

[Dietcoke2025]

I'm so sorry that you are going through this, I've just had my second fail as well so I know how tough it feels. We did back to back egg collections last year so have a couple in the freezer now. Sounds like another egg collection might be your best bet as scary as it sounds. Have you read it starts with the egg - has some really helpful information in it and definirely think it helped us improve our embryo quality. I've just written a post on next steps after a failure and had some really useful comments on testing ahead of our next transfer that may be worth looking at? Hope you are ok xx

[Cooperlane450 in reply to Dietcoke2025]

Hi there, thanks so much for your reply!

I’ve never read the book actually, I’ve ordered it now so I can be prepared. I’ve had a look at your post and there’s some great options in there I’m going to speak to them about when I go in next time.

Im so sorry your 2nd round was unsuccessful too ❤️ we will get there! xxxx

[Millbanks]

Hello lovely,

Sorry to hear about your 2nd negative - its so hard isn't it. You go through so much to get to this point then.....nothing.

I would also be looking at possibly another egg collection. I would speak to your doctor about a different protocol to stimulate fewer eggs but higher quality. I think sometimes the high numbers can be a lower quality.

I would start taking ubiquinol 600mg a day and NAC 1800 mg a day - these help with egg quality and are antioxidents to help with the developing cells. Whole milk is good for egg quality as is the Mediterranean diet (lots of protein and green veg) - also blueberry powder (in smoothies / breakfast) is a great antioxident.

Unexplained infertility is the worst - we had that diagnosis too but after a HSG exam they saw that both my tubes were blocked so I had these clipped before going ahead with a transfer. We also had issues with high natural killer cells so were lucky to have a positive on our 6th go with a steroid protocol.

Are you with a private clinic? If so I would ask them about everything going. Often after 2 fails they will just chalk it up to bad luck and usually won't bother with other testing until after 3 goes (especially on the NHS) but if you're paying privately I would definitely have the conversations now.

xx

[Cooperlane450 in reply to Millbanks]

Hiya, thank you so much for your lovely response ❤️

All of that is so helpful, I’m going to look at the medications you mentioned now! We’re incredibly lucky that we had the funds to go private, so I think you’re right that I need to be asking the questions now. They’ve been great but if I have another egg collection there’s a part of me that thinks about moving, but we’ll cross that bridge when we come to it.

Thank you again ❤️ xxx

[Millbanks in reply to Cooperlane450]

You're welcome lovely - there are so many options when it comes to IVF, it can be a bit overwhelming. I found that doing my own research helped me before speaking to the clinic, so at least I had a bit of an idea what everything was....

xx

[SprinkleGlitter]

Sorry to hear your news. I to had my result come back negative last Thursday for my 3rd. I had 39 eggs collected of which 26 where mature and 11 made it to freeze. Every round I have a change something to see if it will help but so far it hasn't. I have a appointment tomorrow with my consultant. I know they want to do a uterus scratch before my 4th fet so hoping that might help. But it's all so heart breaking I'm now 45 and trying to say hopeful is so hard. I don't have any advice but wanted to reach out as going through the same feelings currently to you. X

[Cooperlane450 in reply to SprinkleGlitter]

Thank you for your message ❤️ I’m so sorry for your loss too, as you said sometimes there’s nothing you can do but knowing you’re not alone can help ease the pain a little bit.

I hope the appointment with your consultant goes well and they can work out a way forward for your next transfer xx

[SprinkleGlitter in reply to Cooperlane450]

Thank you. I hope and send wishes to you to. Being a ivf warrior is hard work, and sending love and hope to all ❤️