Sorry for the long post . Just got negative test from 8th transfer . Did steroids , clexane inj, pio injection and intralipids extra this time . 8th transfer from 4 ivf cycles . Anything else missing . I did have positives before , pregnancy nvr lasted more than 20 weeks . Had miscarriages, chemical , second trimester termination due to genetic reasons and all pgta tested embryos . Here (Canada)doctors don’t suggest wat to do and what’s wrong . They just transfer that’s it . Have 2 left , planning to just transfer both and finish it . Looks like even pgta is useless no good outcome atleast for me . No lining problems , uterus perfectly normal , Should we move to donor , may be it be better outcome ? Any suggestions
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does anyone swear by era ? My clinic doesn’t believe it . And my history I have explained before had 4 pregnancies with 8 transfers . But I always had slow growing pregnancies from start like off by one week . Anything due to progestrone timing ?
I'm sorry that your transfer didn't work. My last transfer applied results of ERA with extra day of progesterone but it was another negative. I'm getting ready for my fifth and final transfer and my doctor doesn't have clear answers for my failures either. My last one was a perfect 3AA and I did autoimmune protocol and applied the results of recent ERA. I think adding the extra 14 hours of progesterone made me lose my window of implantation entirely because my only chemical pregnancy with IVF was after standard hours of progesterone exposure. At this point I have some hope but not a lot as I have one more shot at this working, but it's a lesser grade 6 day 3BA blast. Maybe getting a second opinion would be helpful? I'm considering going to see a reproductive immunologist as my doctor doesn't believe in use of intralipids or IVIG stating it's not evidence based and could be harmful.
My doctor said the same thing about intralipids , ‘it’s harmful’ I don’t understand what more harmful than losing pgt embryos , I went ahead with intralipids thru naturopathy doctor . But ultimately it din help . To be honest I don’t believe in intralipids cos I had pregnancies without that , and I had pregnancies in normal progestrone window so don’t believe in era too much. Between my last pgt transfer (miscarriage) and current one(failed implantation) I added many things extra like clexane injection , continued steroids after transfer , baby aspirin and intralipids but what I skip is down regulation . I prepared endometrium just with day 1 of period using patches and transferred usually I was put on synarel by previous clinic and lupron by current clinic.
moreover in my 3rd and 4th ivf cycle I did embryo banking and got 13 embryos good grades but after I suffered miscarriage for 4th time we tested frozen embryos and only had 5 euploid a out of 13 good embryos. So perfect embryos doesn’t mean they are euploid. But irony in my case just as we trasnsferred 2 pgta euploid we still had one miscarriage. So in my case euploid vs untested both presented worst outcomes
So sorry to hear of your troubles, it's just awful to go through. I think next steps would depend on whether your clinic think it's an embryo issue or a womb issue. If you can get PGTA normal embryos then it is less likely to be the embryos that are the problem. We have had 9 embryos fail to implant (I'm 31), 3 confirmed euploid and the others untested but excellent quality. Our clinic have suggested surrogacy as an option if we have had enough of trying with me. If your egg quality seems poor then I think donor eggs would be advised as next steps by your clinic. I'm sorry you are going through this, it's so soul crushing. Sending you lots of love xxx
Last three transfers were all pgta euploid . Last one was double and heart beat stopped at 7 weeks mark after two good ultrasounds but they were behind by a week . While pgta says chromosome are right what if there are some genetic factors ? I did terminate one pregnancy in 20 weeks due to no kidneys so I’m not fully convinced at the surrogacy option. Looking for some suggestions
I’m so sorry to hear about your losses. Unfortunately, I’ve had a very similar presentation of pregnancies and losses. 12 embryos transferred, 10 transfers , 7 pregnancies and losses at various stages 1/2 trimesters. All with donor embryos (multiple different donors) and the last two I knew for sure baby boys were genetically normal as they ran chromosomal testing of the babies post D&C.
The last 4 I was on a really heavy and ever increasing immune protocols including drugs they give to people to suppress their immune system post organ transplant. Each time I got pregnant, I’d get a few weeks further along, but like you, I’d start measuring behind and then the babies heartbeat would be gone.
With my last pregnancy a very well known and respected reproductive immunologist who has been looking after me, told me that there is a possibility I had a rare condition called CHI. The only way to confirm for sure is to biopsy the babies placenta post D&C. There are no other definitive tests, only biopsy after loss. Long story short, they didn’t biopsy the placenta as asked during babies histology tests so I’ll never know for sure..but I certainly present as if I have it and I couldn’t keep going.
I’m similarly on a surrogacy journey (which isn’t any easier I may say).
I hope you find your answer. This stuff is so tough. Particularly at this time of year.
Your message resonates so much with me . Even our last pregnancy remains were tested and they found it’s a girl but chromosomal normal . I expected it cos it was anyways pgta euploid . I always kept telling my husband it could be embryo problem causing all miscarriage or failure but he believes we should go surrogate as it could be my body . I was under the impression if I could get pregnant but not carry term my best bet is donor . Your msg is eye opener to me .
It’s probably not my place to say, but it’s unlikely for all your pregnancies to end the same because of the embryos when you’re getting PGTA normals. The commonality unfortunately is us.
It might be worth knowing that the Canadian surrogacy programmes are some of the best worldwide and you know you’ve got a couple decent tested embryos remaining.
Have a think. There is never any pressure to go one way or another. Only what’s right for you.
I'm no expert, but I think there are a few other tests you could try - Emma and Alice and for NK cells. Seems like you have done everything else and if they are euploid embryos, probably worth doing a bit of additional testing before you transfer any more. Could you pay for a consultation with a doctor to discuss what might be the problem?
ERA is helpful if you’re getting recurrent implantation failure/ biochemical losses, but you’re getting pregnant so I don’t think they will necessarily give you the solutions you are looking for.
with pgta tested embryos I had one miscarriage at 7w3d , 2 implantation failure . Even I feel the same since I’m getting pregnant sporadically not sure era can do much for me
I think that’s fairly in line with the odds. The way it was always explained to me was that you have a 33% chance with every embryo, which is cumulative, so after 3 you should have a pregnancy. The improved odds with PGTA increases the likelihood of carrying to term/less likely to miscarry. Seems like something else is impacting at that point. Something non-genetic, likely immunological, but complex because steroids and intralipids aren’t enough.
Guess hit all time low with this failure . Too scared to transfer and waste my precious embryos . This never ending journey consumed my life completely
It so so tough and heartbreaking. Each time it doesn’t work it’s so deflating, dealing with the thought of starting right back at the beginning again. ’m so sorry. Sometimes a time-out really helps. I know it’s fighting that feeling that everyone else is going past you and moving forward when we can’t. But it might help you carefully consider what you want to do next. Work it all through. Sending love and hugs.
Even both PGS tested embryos, same strong immunology treatment, it doesn’t work all the time. The accurate of PGS test is about 95%, so I would think it is more about our body. I had 3 PGS tested embryos, I transferred one with strong immune treatment (25 mg steroids + Intralipid + injections), I had my son. But this time when I try the sibling, I had miscarriage for the PGS tested embryo with exactly same treatment. I heard it won’t work each time. Some women would be successful for 1/3 PGS tested with strong immune treatment, in extreme case, it could be 1/5 PGS tested (I see a message here, only worked on the 5th). I think I am very lucky to have my son during the first treatment. But it doesn’t work all the time! How much steroids you are taking?
The normal miscarriage rate is 20%, so far, my live birth rate is 25%! (3 miscarriages with 1 live birth). This road is harder for some women. If you have option for surrogacy, it is not a bad idea!
when a pgs embryo doesn’t implant should we investigate anything ? I had one pgs miscarriage I feel it happened becos the clinic stopped steroids just one day after transfer ? I did not down regulate this cycle . Can it be one reason ? My last two pregnancies I did down regulate using lupron or synarel
I never tested but on Aug pgt double transfer we stopped .just one day after transfer. And pregnancy arrested after we saw heartbeat twice but was already behind by a week measuring. But this transfer I din stop when pgt embryos don’t implant makes me upset .
hello! First I’d like to say how sorry to hear this for you! I know this is a hard road (I’m still on it myself). Have they checked for sperm fragmentation? Since your embryo were tested, it could be the sperm? Can they do further testing on that. Have you heard of the Zymot , it helps pick the sperm with less fragmentation. There are other processes they could use as well, but I only know about Zymot. We used it after our last mc… waiting to see if it worked for us. Praying things work out for you.🙏🏽
We did sperm fragmentation test during one of our early cycle . We had transferred pgta euploid so not sure repeating testing of sperm at this point was needed .
can I ask what your immune protocol is? For example; your dose of steriods? My doctor recommends only 25mg steroids with IVs monthly. I also miscarried PGS embryos but when I did full immune protocol it worked…x
How much steroids you are taking for the successful cycle? I was on 25mg and had my son. When I try the sibling, I have a miscarriage for PGS tested embryo on 25mg, not sure whether it is possible to increase?
I had one pregnancy with 10mg steroid had to terminate due to genetic condition . That’s why for this cycle when they gave 16mg medrol and followed by prednisone 10mg I thought would be sufficient. But if I ever transfer my remaining embryos I will for sure take 25mg
Hi, I’m so sorry to hear this.I’m on the same protocol as you and I manage to get pregnant but I keep miscarrying between 7-8 weeks. I have had 11 transfers now and 4 pregnancies all miscarriages. My last 2 have implanted and I think this was due to diet.,Have you changed your diet at all during the 2WW? this time I cut out sugar and caffeine and had beetroot juice and pomegranate juice daily as well as avocados. I have also seen a recurring pregnancy loss consultant who suggested hcq which I added in the last 3 times in addition to clexane/ intralipid /steroids. It’s really hard I know but praying that it works the next time for you
No Hcq but clexane , steroids and lipids were added. I don’t do any diet change as it’s hard to follow thru . I don’t drink alcohol and I take only one decaf coffee thats all all other my same usual diet . I don’t take red meat as well
Its hard not to be jaded and lose hope when you get told IVF with pgt tested embryos are the answer and then have multiple unexplained IVF failures. All my doctor could say is that it was "bad luck" and if there are immune issues that she is treating them with evidence based treatment. I hear you when you say you don't think you believe in intralipids either. I don't know what will work for me and have little hope left but trying to stay positive. Sending you strength and positive thoughts your way and hope that we get to have a healthy baby at the end of this IVF journey.
I agree to each their own . I would rather try something and be ok with it not working instead regret not trying . My take is over the last 6 years of ivf treatment , I did keep some learnings on my body and what worked and not . Someday I hope it will come to help . All the best for your journey . Take care
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