Transfer of our hatching 5AA blastocyst has failed. I am sad to think it could be because my lining was too thin. It only got to 6mm though clinic insistent was healthy and trilaminar.
We have one 5AB in cryo from our latest 5th cycle now.
Because of our disastrous 4th cycle in September with no blasts, these two were not PGTA tested. Our other blasts from the first 3 cycles were also not PGTA tested but given age at the time and number of good quality blastocysts made, the odds they were all aneuploid would be very very bad luck though I guess not impossible.
Only had one biochemical in 6 transfers (after being prescribed pred 25mg, clexane 40mg, Lubion and utrogestan for my transfers following various tests. Lower doses of pred and clexane did not help ). I’ve had all the recurrent implantation failure tests now. DH has had DNA frag and semen culture etc.
I turn 38 early next year. I’m not sure if I should transfer that remaining untested embryo in January and see what happens. Or decide now to do a 6th cycle while I’m still 37 or only just turned 38 and bank some embryos, likely abroad, with PGTA testing where more affordable given our small numbers of eggs/blasts. I have low AMH and when I stimmed to get more eggs we got no blasts but when I’m stimmed to get 3-4 eggs we get 100% fertilisation and a very good quality blastocyst rate.
Any thoughts welcome.
I am just really tired of it all today and hard to see the light. But I know we are not ready to stop. Thanks for reading this far xx
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I'm so sorry it's another BFN - I know the feeling well. My journey sounds quite similar to yours.
My clinic have always said that even if your lining is on the thin side, as long as it's even and trilaminar then it should be ok.
We opted for PGT-A testing as we had a fair few embryos in storage from 3 different rounds - and didn't want to keep putting back embryos that stood no chance.
Have you had an ERA test done? It looks at the timing of transfer and for me it was 24 hours out - so this could be worth looking in to?
I honestly don't think between 37 / 38 there will be much difference in your egg quality. If it were me I would be tempted to use the remaining embryo first, rather than do a whole other cycle only to find that the original embryo stuck. But then if you would be happy with other embryos in storage then maybe it is the right move. It's a really tough call.
I was 38 when ours finally worked on our 6th transfer with: new ERA timing, PGT-A tested embryo, steroids and intralipids. But then tried for a sibling last year with exactly the same protocol and the first 2 failed and the 3rd was an mmc.
Thank you 🙏🏼 I have had ERA (and EMMA/ALICE) done after our first two transfers failed. I think we just have to keep going. DH is keen to try this embryo first I think. I think he worries about the effect of the stims on flaring my endo back up. Finances are a struggle now though as we’ve had to self fund due to my AMH at 34, all the investigations and my endo excision adding to that cost - if I had more money I’d probably bank embryos, do PGTA and see a proper RI. But we’ve already had to spend tens of thousands to get to this point with nothing to show for it. Thank you for sharing your story, it gives me hope ❤️
Hi. I’m so sorry to hear that your cycle failed and hope you have plenty of support just now. My thought was perhaps your lining was a little small, but I guess we have to trust the specialist. I did wonder whether you have had your Fallopian tubes checked for scarring or blockage, which in turn could cause excess lubrication to leak into your womb, where it is often believed to prevent implantation . A hysteroscopy could look inside the womb and biopsy the lining too. Apologies if already done. Some women do have acupuncture to help with lining thickness. As you suggest it could be an idea to have a fresh cycle and store some embryos. Lots to think about, plus the one you already have stored. Maybe take a little time for yourselves. I wish you both well with whatever you decide. Diane
Thanks Diane 🙏🏼I have had hysteroscopy, lap and dye and HSG. DH and I have always said we need to feel we’ve done everything we possibly can and leave no stone unturned (within limits of finances) so I’m always happy to hear suggestions in case it’s one we haven’t done yet. I love my acupuncturist! She’s great and while it hasn’t boosted my lining thickness maybe it does mean it’s nice and healthy. Thanks again ❤️
Hi lovely I’m really sorry to read this if I was you I would put the one back you have you never no lovely and while you are doing that you can get your little plan together of what to do next .
I was going to say go abroad next time maybe you could both do with the break and in my opinion it’s a lot better in other countries the care the treatment the response time to your questions I was doing ivf from 2013 and only got my bfp in 2022 when I found the right clinic for me I’ve always done a double transfer but you can transfer more or less up to in other countries
You are still young lovely I know it’s bullshit what we have to go trough and believe me I was drained for years but you will get there in the end your on all the right meds it’s just your clinic I would change and make it in to a bit of a holiday aswell
hi lovely I'm very sorry for your BFN, i just wanted to send you a big hug, i know how tough this all is. I'd also be tempted to transfer the embryo first, sometimes you do get 1 lucky one, and see where that takes you. If the worst happens it may only be a 3 month difference which might not impact much the results of a new fresh cycle. Regarding PGTA we paid for this on our last fresh cycle, but we only managed to get 1 good quality 5 day blastocyst so we ended up transferring that instead. I'm waiting for a new fresh cycle and we have paid again, but we'd only do it if we get 3 blastocysts at least. Maybe have a chat to your clinic and see if they are flexible like ours?
Also, I know another lady in this forum has got thin lining and had her little boy despite of that xx so it can also work. But you can try to do things from next transfer like beetroot , exercise etc
Allow yourself sometime to grieve and recover from this , is very normal to feel the way you're feeling right now after another failed cycle, try to do nice things and pamper yourself to help you recover quicker, once you're over this you'll see things in clearer perspective. Wishing you all the best of luck xx
I’m so sorry you’re having to go through this again!
I haven’t much experience to offer as my first ever transfer (FET) was cancelled today as they weren’t happy with my lining.
My lining is very thick and they found it to be irregular and have asked me to get a hysteroscopy- though I’m convinced my natural lining is just very thick and irregular so I don’t know where that will leave me after the procedure (I had a hysteroscopy a year ago and it was the same then but there were no issues and I conceived naturally 5 years ago with my irregular thick lining).
The consultant told me they would prefer it be thinner and regular, which I thought you might find helpful to know xxx
Thank you. I’m so sorry your FET was cancelled today. I’ve been there (for thin lining issue back in 2022) and I know it’s so hard. I hope hysteroscopy is helpful. Welcome to DM me if you want to know more about my hysteroscopy experience (which was positive no stress. )xxx
Your post resonated with me as I’m also losing hope but not ready to stop trying and it’s unclear what to do next! I’ll be 38 next month so also worried about another collection when I already had low amh a year ago. How many children would you ideally like? If you want more than one, I’d suggest another collection. Sometimes it’s nicer to do a transfer when you know there are more chances in the freezer. I’m also planning to do pgta next collection, even if I only get one blast, just to know if it’s embryo quality or something else. Going to work with a fertility nutritionist before the next cycle and see if that makes any difference. Have you been to professor Brosens implantation clinic? That’s another route we’re going to try but unfortunately a 3 month wait for an appointment which doesn’t feel very good having such a long wait before we can consider a cycle. Good luck!
Thank you! I’m so sorry you’re facing similar to me. I found Professor Brosens really nice and positive. It helped confirm I definitely need prednisolone which makes me feel better when I feel fat and awful taking it! Gosh that’s a long wait I must have been lucky when I went for the tests.
I found seeing a fertility nutritionist really good as at least I’m doing everything I can control in this. DH too.
I am still so unsure really about PGTA I go back and forth. I think it’s because we make so few eggs/blasts but then it would be so nice to know the embryo is euploid going back.
I have always thought two, but even one child feels so far out of reach now you know.
I just wish someone could tell me the “right” answer but of course there isn’t one. I just have to try and make best decision can.
Gosh you really have tried a lot so far! I’m so sorry you still don’t have answers or success. I know it’s impossible to imagine it ever working let alone working twice but if it does work, it’s about 2 years before you can try again and with age/low amh it’s better to have some frozen from now than face another collection later. I’ve had my most recent treatment abroad and do find they’re a bit more open to trying different things than in the uk. Bear in mind that some countries have different rules on pgta. In Greece you have to submit an application to the authorities to get approval and it takes around 10 weeks to come through which does delay treatment. Have you tried the immunology route? I know it’s a bit controversial and I’m still undecided as to whether it’s worth it. I hope whatever you decide for next steps, you feel it’s the best for you. Sending you lots of luck for your next transfer/collection x
I just wanted to say thanks as always to all you ladies for your support.
We had our review which was a very encouraging appointment. We’ve decided to go ahead with endometrial PRP and two further stims (using the same protocol which gave us 3 blasts, two of great quality in this latest cycle) for embryo banking with PGTA. Wish could do more but all we can afford right now. And then we can focus on transfers.
Now it’s just a case of deciding if we do it in Greece or UK. Off to Greece soon to have immune tests and a consultation, and update hubby’s dna frag and analysis etc before another round. That should give us a better idea.
Thinking of everyone at this challenging time of year. Not a bad thing for us escaping Xmas here for some winter sun in Greece with a good reason to spend the money (still cheaper to do the tests there even with travel costs!!) xx
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