Failed transfers

[Flounder84]

Hello, I’ve had x3 ivf failed transfers ttc a sibling, x2 bfn and x1 chemical. Eggs were collected when I was 35

Apparently these have all been “top” embryos which actually makes me feel worse! I have x1 “nice” embryo left in freezer but been advised to have hysteroscopy before transferring.

Someone told me because the previous transferred failed this last ones more likely to fail too because they’re from the same “batch” if that makes sense (all from same egg collection) I just wondered if anyone knew anything about this as I can’t find out anything about it - I don’t really want to wait /go through a hysteroscopy and go through all that if this just isn’t a great batch of eggs! Probably part of me just wants this journey to be over now but any information really appreciated x thanks

[Football61]

Hi. I’m certainly no expert, but I’m not sure there’s such a thing as a “bad batch” of eggs. You can still have a precious euploid egg amongst a group of aneuploid eggs. Or it could be a problem with implantation, rather than the eggs themselves. Can you speak to a consultant or embryologist at your clinic about this? Wishing you the best of luck x

[Ttcasibling]

Hi, oh gosh what a journey. How old are you? Could you start IVF again? We had our 1st through IVF but no other embryos were left to freeze. We are trying naturally as I feel pregant a year after our 1st was born but sadly the baby wasn't meant to be. I don't know how much it will take out of me/us doing IVF again and worry how much it will detract from enjoying our 2 year old 🙈

[Ttcasibling]

Just looked up about the hysteroscopy, it doesn't look too invasive I'd definitely consider it... Good to get things checked out and much less invasive than having to do the whole IVF process again if they pick something up they can do something about to increase the chances of this last embie staying put!

[Fruitandflowers]

I don't think based on my experience you typically get good and bad batches - I think that's more something that impacts whether you get any blasts at all. Each egg and sperm is individual. I guess if there was a genetic issue that had somehow only arisen because something went wrong at the point the sperm developed, and that didn't happen again, then that may be possible but I'm not sure how likely that is. All my blasts have been 'top quality' and it was FET number 1/transfer number 3 that worked. I also got an early loss and a BFN from that same batch. My clinic said the odds were about 1 in 3 with transfers where nothing else was an issue, and that's proved right for me. It's incredibly upsetting and frustrating though when you feel you've come so far and I totally get that it makes you feel worse when they say it was a great embryo becausethen it feels more like you and your body are to blame (not at all btw). I had a hysteroscopy years ago so I didn't need to repeat it but that and every other test I've had have shown no problems, so it's still unexplained. x

[DianeArnold Partner Nurse Fertility Network UK]

Hi Flounder. Good you thinking about a hysteroscopy. I would consider getting your Fallopian tubes checked too for any blockages or scarring as fluid drips can be responsible for an embryo not implanting. Good luck. Diane

[Flounder84 in reply to DianeArnold]

Thanks Diane. I conceived my first child via iui, he is now 3, so my tubes were checked prior to the iui and there were no problems. Is it likely there could be blockages or scarring etc since they were last checked ?

[DG2022]

hey. So sorry this has happened to you. I’ve had 3 miscarriages (ivf) and one ectopic (natural)

I had some further investigations into my immune system and natural killer cells. Turns out was likely reason for my miscarriages although I will never know 100 %

I also hear from other ladies at my miscarriage clinic they had one child then keep having recurrent miscarriages.

I’m currently pregnant with my 4th FET on immune protocol and it’s the furthest I have ever got.

I would really recommend have these tests done.

Don’t give up hope x

[Lucyhannah1]

hi, I have a daughter who’s nearly 3 from my first cycle of ivf. We had a frozen transfer and we had 8 embryos in total. I’ve since had 3 failed transfers, like you all top grade embryos. There seems to be no reason behind it 🤷🏻‍♀️. I’ve done single & double. Although I do think the last failed one in august my progesterone levels weren’t checked till the day of transfer and they were below what they like it to be. I’ve got two embryos left not as good quality as the other 6 but who knows. They offered me hysterscopy or the endometrium receptivity test but there is no evidence this helps . I also agree with you, part of my wishes I could move on and end this journey but I know I can’t leave the last two embryos. Good luck x

[Flounder84 in reply to Lucyhannah1]

Sorry to hear you’re in a similar position 😞 do you mind me asking if you are going to do the hysteroscopy etc or just proceed with another transfer? I feel exactly as you describe after my last transfer I said I wasn’t going to do anymore but then realised I actually can’t leave that last embryo so I am going to have to go through it again but the hysteroscopy business is delaying the agony in a way as theres a wait for that, I’m just not sure if I see the point at this stage of having that procedure however I tend to do as I’m told and find it hard to say no if that’s what the consultant advises as you don’t want to have any regrets I suppose. x

[Lucyhannah1 in reply to Flounder84]

No I’m not going to, it’s added cost and delaying further cycles. If I hadn’t had a success with my daughter I would probably explore further testing. I’ve had 3 failed cycles in 12 months. I do wonder if it’s just down to the embryo, who knows. Once I’ve used these two embryos I won’t do another collection though. I will have to accept that I tried my best to give her a sibling but it wasn’t meant to be. Good luck for your tests and cycle xx

[Flounder84 in reply to Lucyhannah1]

Thanks I feel the same I know I will have tried my best, wishing all the best to you too thanks for your replies xx

[Bonita928]

hi, I’ve been in a similar situation. My first was conceived from 1st IVF cycles when I was 38. I since had 1 failed and 1 early loss. I’m currently on 3 attempt. This time my consultant prescribed Lubion injections. Not sure if it’s helped but just tested positive and now waiting to see how the next couple of weeks go. All mine were “good” embryos so no real reason for the unsuccessful rounds, especially as I already have one special boy from that IVF round. I would look to have the extra investigations anything to help with your next attempt. Wishing your all the best xx

[Twiglet2]

the batch thing is nonsense! We got 6 embryos from our very first round. The fresh transfer failed, 2nd double transfer was an early loss and 3rd transfer was our wee boy (our 4th best embryo a 4BC). After him we went back and tried with the other 2 remaining both BFN. So out of that ‘batch’ of 6 one of them was just perfect whilst the ones hadn’t been 😊🤗 fingers crossed for you the one left on the freezer for you is your ‘one’ too xxx 💜

[Flounder84 in reply to Twiglet2]

Thanks so much this is just what I needed to hear ❤️ i still feel on the fence whether to do the hysteroscopy really but I suppose will see what consultant says and I will put the embryo back where it belongs either way and just give it a try

[Twiglet2 in reply to Flounder84]

I opted to not have the hysteroscopy they had suggested earlier in the year too (as time is not on my side and it’s a few thousand ££s) but that was a really personal choice as if I had the time and money I may well have done it even for peace of mind xx

[Wishinandahopin]

I wouldn’t have thought it was a batch thing - though I have thought that at times. We had two failed Euploid transfers from the same batch. But then did loads of testing, inc hysteroscopy and immune testing etc over a year and I’m now pregnant with a mosaic embryo from the same batch. I think it’s likely there’s something else going on than just a ‘bad batch’. The problem is you can never really know without testing everything. Which is what we did.

[Spicycurry]

Have you thought about doing Emma, era, Alice, nk cells before next transfer. I had a biopsy which showed I had low nk cells in endometrium and slightly high in blood. For endometrium, I had neupogen infusion on first day of confirmed ovulation and hcg infusion on transfer day.