Suggestions after second failed implantation

[Smang]

Hi everyone,

I’ve spoken with my clinic and doctor and as I suspected they said it is just bad luck the second transfer failed as well. I was wondering if you could please give me some suggestions on what I could ask the doctor? Or if anyone else has had failed implantation was there any other testing that they could do either on my uterus or the donor eggs we have remaining?

I have had a hysteroscopy which they did not find anything. I have also had implantation cuts. My husbands sperm had been tested and it came back with great results. The donor eggs we had all made were grade 5aa blastocyst. We have three remaining.

The doctor would like me to try again on the next cycle, to take advantage of the implantation cuts while they are still there.

Any insight or feedback would be great.

Thanks

[NDE1987]

Hey hun, I have had two failed Implantation aswell. I went on to have my NK cells testsed at covernty and Warwick hospital and they came back slightly high. So this next cycle I am going to take steioids to see if this aids implantation. Fingers crossed it does help! Sorry for your cycles not working. Take time to heal and when you feel ready try again xx

[Smang in reply to NDE1987]

Thanks for respond NDE1987,

I will ask about the NK cells but I know was given prednisone which I think is used for treating NK cells?

How do they test for NK cells? Is it a blood test?

Thanks

[NDE1987 in reply to Smang]

They took a biopsy of my womb. Again yeah those are the tablets I am going to be put on! I also had a scratch done on day 21. Let's see if these changes work! X

[Smang in reply to NDE1987]

I have my fingers crossed for you!

[Cinderella5]

We had some biopsies taken at same time as hysteroscopy, consultant cut away what he called thickened scar tissue. Biopsies came back clear but my bloods have come back with a few clotting issues so on clexane for next round and also having intralipids before transfer this time to help with slightly raised nk cells. I have had two failed transfers with my OE cycles and thought we had cracked it moving to DE. We transferred 2 hatched blastocysts and our consultant was convinced this would be our time but no. Hoping the changes help for next round. Perhaps it's just bad luck, nobody really knows!xx

[Smang in reply to Cinderella5]

Thanks Cinderella, I know I had some tissue cut away as well during the hysteroscopy. And both of these failed rounds I have been taking the clexane injections for clotting. I will ask about the NK cells but I know was given prednisone which I think is used for treating NK cells? Maybe I need a higher dosage?

I hope both our rounds are ours next time. I will have my fingers crossed for us both xx

[Cinderella5 in reply to Smang]

My consultant wasn't keen for me to do the prednisolone. I'm doing intralipids only....bit unsure of the reason. Hoping we've just had really bad luck!!xx

[Smang in reply to Cinderella5]

I’m not sure what intralipids are? I will have a look and see what the difference is and see what my doctor says. Thank you though for your support and the information xx

[Cinderella5 in reply to Smang]

I posted about intralipids if you look back my posts. I've no idea of the science behind it as it's basivally an IV of soya oil & eggs but seems to work for some. lianm8 used this on both of her successful rounds! You're welcome, it's good to know we're all there for each other!!🤗xx

[Smang in reply to Cinderella5]

Great thanks, I’m going to have a look at your post xx

[Hopeandwishes in reply to Cinderella5]

Hi Cinderella, hope you’re well? Did you get the level 2 bloods done? I recall you were thinking about exploring the nk cells testing. How did you get on? I think nk cell testing will be my next step following my 3rd miscarriage. X

[Cinderella5 in reply to Hopeandwishes]

Not sure what level 2 bloods are?! My clinic have done so many bloods and have been very thorough! Found clotting issues & no cell issues. So clexane and intralipids for next round. I really hope you you find answers for your miscarriages!xx

[Hopeandwishes in reply to Cinderella5]

Chicago level 2, nk cells I believe. Level 1 tests cover the blood clotting issues x

[Cinderella5 in reply to Hopeandwishes]

Yes, had them all I think!x

[Hopeandwishes in reply to Cinderella5]

Thank you! Fingers crossed I can get some answers. Glad that you have a plan going forward, fingers & toes crossed for you! 🤞🏼 x

[Cinderella5 in reply to Hopeandwishes]

Sorry just googled! Yes had all the tests done through our clinic in Athens.xx

[Hopeandwishes in reply to Cinderella5]

Brilliant! Was it expensive if you don’t mind me asking? Xx

[Cinderella5 in reply to Hopeandwishes]

I had mine done altogether with my hysteroscopy which includes uterine biopsies & level 1&2 bloods. It came to €2000 so not sure how much it would have been separately.xx

[Hopeandwishes in reply to Cinderella5]

Thank you! That sounds quite reasonable for everything. Food for thought xx

[Cinderella5 in reply to Hopeandwishes]

Yes it's definitely a lot cheaper than some of the clinics here!xx

[sanchia46]

Are you doing double or single transfer?

[Smang in reply to sanchia46]

Double transfer, they don’t seem to want to stick We have three frosties left now. So will do two again and then will have one left

[Hidden]

My clinic has suggested a huge list of bloods to check for possible causes. In uk normally only done after at least three failed or miscarriages xxx

[Smang in reply to Hidden]

Thanks snuggles, any idea of the list of blood tests? My doctor just said it was bad luck, but I don’t know. I’m just worried

[Hidden in reply to Smang]

Protein c and s lupus anticoagulant,

Anti thrombin 111 homocysteine, anti b2 glycoproteins IgG and igm

Anti cardiolpin IgG IgM iga

Cykoteines th1/th2

Lymphocytes sub population

Prothrombin gene factor 11

Detection of 2 mutations gene cftr and

Detection of polymorphism mthfr

Hope this helps

Ps this I might need a blood count after all of these lol xx

[Smang in reply to Hidden]

Brilliant thank you! And yes I think you might just lol

I’m going to speak to my consultant and GP about getting some of these tests done. Thanks so much again xx

[Tugsgirl]

Sorry to hear this. It is very hard. Have you thought about using the embryo glue? According to the HFEA it shows promising results. We always use it xx

[Smang in reply to Tugsgirl]

Thank you! I’m sending the consultant an email with questions and will definitely see if we can use embryo glue.

[Hopeandwishes]

Hi Smang, I’m not sure if it’s relevant or not but following my third miscarriage I am going to look into natural killer cell testing and I have read that it can also impact implantation. Quite a controversial subject but could be something to look at? Good luck! X

[Smang in reply to Hopeandwishes]

Thanks, I’m defin going to bring it up with my consultant xx

[Desperate4blue123]

Hi. I have had 2 failed cycles as well. I timed both with the bcp pill and I don't next time I have a transfer. I feel it just doesn't suit my body. There is a bacterial infections test you can do at locus medicus in Greece. If u search it u can send your samples via post and then they provide the results via email and if diagnosed advise a way forward. I hear that bacterial infections can cause embryos not to stick or make if further. Yes nk cells are a must to test. I'm hoping to go to Coventry to check mine but only after I have had a hysto. Dr s in London usually puts people with elevated nk cells on 20mg steroid daily and other meds such as resveratrol high omega fish oil and vitamin d. Hope this helps.

[Smang in reply to Desperate4blue123]

Thanks for your message, I’ve had the bacterial infections test as my clinic is in Athens also, they took a sample when I did my hysto. Interesting though about the vitamin D I started taking last month and that was because my GP suggested it. So hopefully for next round it would have kicked in.

[Cinderella5 in reply to Desperate4blue123]

My clinic has put me on resveratrol, omega fish oil, vit D and but C too Smang .xx

[Desperate4blue123]

I guess any thing is worth a shot isn't it hun. For my next round the only thing I won't be having is the LIT otherwise I'm trying it all.