Investigations after failed transfers

[Ttcbythesea]

Hi all,

Any experiences with investigations after failed transfers please? I'd like to know what tests etc have been worthwhile to ask my clinic about. I don't think they do that much advanced.

I know hysteroscopy is an option and DNA frag.

We've had three failed transfers with seemingly good embryos, then a round with no fertilisation.

Tested thrombophilia, vit d, had a scratch but was with failed fertilisation cycle and I'm sure biopsy was taken with that.

Thank you. X

[Orla9298]

I used locus Medicus in Greece for lots of investigations, they were really good and did a free telephone consult. They did the dna frag test for us but also semen cultures, vaginal swab cultures, hidden infection period blood tests, and some genetic tests

[Ttcbythesea in reply to Orla9298]

Thank you, so did you just have tests with them but treatment in UK?

[Orla9298 in reply to Ttcbythesea]

It was all by postal kits - they send it all with instructions and you send back all the samples and blood draws. There was very specific instructions on the period blood one about storage. Xx

[Ttcbythesea in reply to Orla9298]

Thanks thats helpful x

[Future1000]

I had 3 failed transfers, preparing for my 4th.Did a full hormonal check up + thyroid test for me and semen analysis for my hubby b4 1st transfer and 2nd transfers. Changed clinics, did the blood clotting tests (Factor V, thrombophilia, MTFHR etc...) and autoimmune tests all came back normal, did 3rd transfer, it failed.

Before the 4th transfer did a laparoscopy and hysteroscopy to check for silent endometriosis, we found stage 1 endo on ovaries and pelvis and removed it. Now recovering and my next FET will be by end of september and crossing my fingers it will work this time.

I'm 40 yo doctor says age is the main reason, but investigation is very important, bcz i have a good amh and everytime we get a good number of embryos of good quality.

[Ttcbythesea in reply to Future1000]

So frustrating, wishing you well for the next.

Not heard of factor v or mtfhr...always something new! Was the lap and hysteroscopy with sedation? Hope you're recovering well. X

[Future1000 in reply to Ttcbythesea]

Factor V and MTFHR are genetic mutations related to blood clotting which in some sort affect pregnancy. Lap and hystero were under general anesthesia, but went home 4 hours after surgery, took me 1 week to recover and another week to fully go back to my normal routine (driving, exercising and home work). Yes it's frustrating and exhausting, but we keep our fingers crossed with every new transfer.

I wish you all the the best in your journey, and doing further investigation after failed cycles can be an additional step toward success 🍀🤞

[GrowingUp in reply to Future1000]

Hi Future1000, did you have to do the lap and hystero privately or could this be done on the NHS?

[Future1000 in reply to GrowingUp]

Hi darling, I don't live in the UK. In my country NHS covers 80% of lap and hystero if doctor's report lists that I have a fibroid or any other condition that requires surgery. In my case there's a small fibroid so they covered it and the remaining 20% were covered by my private insurance.

[GrowingUp in reply to Future1000]

Thank you for your explanation!

[Buisquits]

I've just came back from my follow up appointment after failed FET. It is so frustrating and upsetting. The whole journey is a lonely, long challenge but the reward at the end of it is making up for all the pains..

We. Are going for hysteroscopy and prostap. Another 4month wait...

[Ttcbythesea in reply to Buisquits]

I empathise completely. Not heard of prostap so one for the list. Thank you. Is it 4 months to give time for those and recovery? I should prob have jan in my head x

[Buisquits in reply to Ttcbythesea]

4 months time is to calm down my endometriosis and do hysteroscopy. Otherwise we would be starting in 2 months.Prostap is a hard experience and I am not looking forward to it at all. But we all do whatever we can don't we

[Hanj10]

My first FET (with Chromosomally normal embryo) failed so we did TH1:TH2 blood test to check for immune problem. It came back high so I did 2 x intralipids infusions before transfer as well as steroids and endometrial scratch and it worked! Prior to starting IVF we did the sperm DNA frag test as I had 5 natural miscarriages and that came back high so hubby was on menevit supplements for 3 months prior to ICSI. I also tested positive for PAI-1 polymorphism which causes blood clotting issues and so was also on Inhixa blood thinners and aspirin from transfer days.

[K8dferXdder in reply to Hanj10]

Hi there, can I please ask you where in UK did you perform your tests? I am looking for London but can’t find where to book. Everywhere they seem to require GP referral. Thanks 🙏