failed cycles after success

[Lucyhannah1]

Just wondering if many people have experienced a successful ivf cycle and then repeated failures after for a sibling?

I was very lucky that my first frozen cycle with two frozen embryos resulted in my daughter who’s now 2.5. We have had 2 failed single frozen transfers since then. Embryos are from the same batch as my daughters. We are now considering a double transfer as we have 4 frozen embryos left. I can’t see myself being able to go through it all 4 more times if I’m honest so am thinking double transfers after the failed single transfers however the worry is the risk or multiples. So hard to know what to do!

[Orangeflowers]

Yes, I was successful on my first frozen double transfer and have had 5 fresh cycles since last April with no success yet for a sibling. The fact you have so many blasts is a good sign. Depending on your age, it may be recommended to transfer double. Good luck x

[JA-fnuk Partner Nurse Fertility Network UK]

Each cycle can be and frequently be entirely different from the one before Just to wish you luck when you resume treatment

Take care

Janet

[SianieShorts]

hi I was successful with our first round of ivf in 2017 and we have a beautiful son. We have since had 5 more transfers. 3 failed, 1 resulted in miscarriage at 9 weeks and the sixth transfer…I’m currently 10weeks pregnant.

Many times we thought it was the end of the road for us but that feeling and desire just didn’t go away. We considered double transfer and very nearly went down that route but for us we decided that we would rather be 41 or 42 with 1 baby(assuming the transfers would be successful) than 40 with twins. This was just our decision and it was a very fine line.

I can totally understand why people go for double transfers as each and every cycle takes such a toll and time is ticking .

I wish you lots of luck …rest and reset xx

[Twiglet2]

🙋🏻‍♀️ trying and trying for a sibling and it’s not working 🤪 we had our little boy after first round of IVF with 3rd transfer (4th embryo).

We started trying again 6 months after he was born and he’s now 2 since then we’ve had:

2 single transfers of the remaining embryos from first round

Fresh round double transfer then single frozen

Fresh round double transfer (chemical)

Fresh round double transfer negative this week. Nothing to freeze this time or last.

I dont know your age or quality of the embryos that you have left as that’s a big deciding factor for me and the clinics usually on the multiples risk you mentioned but if you want to go a little faster it’s defo an option but as you can see not always a guarantee! It’s so hard when you know it can work from past experience and it doesn’t! at first I felt I could just try a couple of time but here I am a year and a half later contemplating another fresh round! You find the strength from somewhere 🤗💜 xx

[Lucyhannah1]

Oh wow so you’ve had double and single transfers too. It’s like the roll of a dice. Did you have any add ons? Like endo scratch or glue?

I’m 35 in July. All the embryos I have transferred in total (4) were all 5AA or 5AB. I’ve got 4 left which are 5ABs and 4AAs I think. I am still in two minds about a double as I would much rather a single pregnancy than a multiple but at the same Time I’ve had two failed single transfers now. The embryos I’ve got left are from a fresh cycle from when I was 31.

wishing you luck if you decide on another fresh!

[McQueeny]

my son is the result of our second IVF cycle (3rd embryo transfer). We then had 2 egg collection and 6 transfers - one chemical and the rest BFN.

We decided to do one last egg collection (no. 5, I’m now age 40) and I’m currently 8 weeks with a sibling 🤞🤞💫 early days but at least we’re here. It was much tougher to get the sibling than I expected, I thought it would be more similar to the first time - but I guess we’re both older…. (We started trying again with IVF when he was 18 months, he’s now 3.5). x

[rainbowbaby8320]

Hi Lucy

I'm sorry you are going through this. Yep - this is happening to me. I fell pregnant with my son on my first round of ivf in 2019... I had three frozen embryos put into the freezer. They were all good/B grade embryos. This is what happened next:

FET 1 - Miscarraige

FET 2 - not pregnant

FET 3 - not pregnant

Assuming it was my eggs (ratio was 1/4 would be good from those eggs or 25% live birth), I proceeded with another fresh cycle. I ended up with two B grade blastocysts. This time I had them screened - one was genetically normal, the other one wasn't. I had the ok one transferred a month or two ago - result: not pregnant.

I have mentioned on another post that my consultant now thinks I have an auto immune diease (she has also checked my womb and it's normal and my lining is normal). I also mentioned that the covid jab is causing a 'new onset of auto immune diseases'...

See one medical paper here on gov website in America:

ncbi.nlm.nih.gov/pmc/articl....

Another thing with me is my breast implants - that also causes it...

Maybe you should talk to your consultant and ask them to give you auto immune drugs and blood thinners at your next cycle. You will see on a post I made about my body killing my embryos that lots of women responded with the same issue and they were given auto immune drugs and went on to have a baby (or a few!!). I really hope this works for me... I am also having my breast implants taken out in July...

I hope you find some success..

You might also want to consider pgta testing... I don't know your age, but this helped me go into the last FET cycle because I was sure it would work?! the disappointment was obviously crushing when it didn't! but the interesting thing is, out of my two B grades on the last fresh cycle, the one that was developing fastest, was not genetically normal in the end!! so they probably would have transferred that one without the pgta screen and right now, I might have been having a miscarriage! so I'm really glad I did the screen. Also, it made me sure that it's not my eggs? and it allowed us to consider other issues?

I hope that helps?

[Lucyhannah1]

thanks so much for your reply. It’s crazy how you can have a successful first try and then the struggles after.

I have thought about the genetic testing on the embryos I’ve got left. As I have used all brilliant grade embryos which haven’t taken. They’ve also said my lining and endometrium (I think) is fine. I’m 35 in July.

Interesting re the Covid jab - I’ve heard lots of mixed views on this.

[LSandJ]

So frustrating! I have a friend who went for a double for the sibling and ended up with twins (after double the first time just ended in one!) It is certainly a risk. As it is the same batch you know the quality is roughly the same (although obviously can vary). But doing a double doesn't increase your chances that much - I can't remember the stats but more like 10%. I'm assuming they're not PGTA tested? I'd be inclined to stick with one (if you definitely don't want twins). Although I understand how hard it is and whether you can keep going. I'm getting near then end of what I can manage (although I think that one minute and then plan in the next breath what I could do next!) So bloody hard to know what's best!

[gerifit]

Hi lovely, yes. We got very lucky and had my little boy from a fresh transfer from our first cycle. We’ve been trying for the last 2.5 years for a second, but had 3 failed transfers and one miscarriage. We ran out of embryos so have done another egg collection and had the new embryos PGT-A tested so we can rule out any issues with the embryo if we continue to have failures. It’s totally heartbreaking when you just want to give them a sibling. Sending loads of love and luck to you. Xx