First FET: when did you start baby aspirin? Anyone has MTHFR heterozygous gene?

[FrancyItaly]

So the doctors here in the UK state I do not need baby aspiring, while my doctor in Italy recommended it due to my recurrent miscarriage and the fact that I have heterozygous gene. Nothing worrying but I would like to try the baby aspirin. When did you start?

[XOXO13]

Hey, I started aspirin on D1 of my stims journey. Before this and before I actually started IVF, my consultant advised that if I were to fall pregnant naturally, to start taking baby aspirin daily straight away. Best to check with them to confirm though! X

[FrancyItaly in reply to XOXO13]

Thank you, I will start today! x

[Pnw2020]

Hi. It should be perfectly safe to take as it’s such a small dose. I think some clinics also prescribe clexane with recurrent miscarriage. I presume you will also be on progesterone. Also I think you need to take methyl folate rather then folic acid with the MTFR gene. Good luck for your FET x

[FrancyItaly in reply to Pnw2020]

I am with NHS now and they said I don’t need anything but I will self prescribe my low dose aspirine from today. Will buy Methyl folate too, thank you for the suggestion. What is the dose I need to buy? Thank you x

[Pnw2020 in reply to FrancyItaly]

"It starts with the egg" recommends at least 800 micrograms daily but maybe you could check with your Dr in Italy? Presume you have had your thyroid checked?

[FrancyItaly in reply to Pnw2020]

Yes Thyroid and Thyroid antibodies all good, I’ve checked it many times. It’s the one thing I don’t have 🙏🏻

[MrsOrangejuice]

I didn't take it for my fresh transfers but tried it for my FET - think I started a couple of weeks before the transfer and then carried on after BFP. I asked my fertility consultant about aspirin before I had the FET, having had a couple of early losses and read blood clotting can sometimes be a factor, and he said he wouldn't prescribe it as I didn't have any diagnosed medical condition and even if I did there were better blood thinners they would use before aspirin. However, he said one small dose of aspirin a day wouldn't hurt and if it made me feel better he had no issue with me taking it.

[FrancyItaly in reply to MrsOrangejuice]

I will start today with the baby aspirin and if I get my BFP I decided I will go back to my old private clinic and hopefully be monitored closely there. Thank you x

[Millbanks]

Hi lovely, I took it for all my FETs and started on the same day as oestrogen.Best of luck xx

[FrancyItaly in reply to Millbanks]

I started oestrogen last Tuesday but hopefully it’s still ok if I start today! Thank you x

[Millbanks in reply to FrancyItaly]

Oh yes that should be fine. I think it's most important to help the blood flow to the uterus, so can help with your lining but mainly for helping the embryo implant.x

[FrancyItaly in reply to Millbanks]

I am also doing acupuncture so hopefully all of this will help! After 2 unexplained miscarriages I would try anything! Hope you are doing well hun x

[Millbanks in reply to FrancyItaly]

It's definitely worth a try! BTW I took 75mg Aspirin which was fine x

[FrancyItaly in reply to Millbanks]

Do you know if you have this mutation? x

[Millbanks in reply to FrancyItaly]

I don't know, I've never been checked xx

[Chel91]

Hi lovely, I started it at the beginning of my cycle. I take 81mg where I am, but I think in the UK they usually sell it as 75mg tablets. You can get it over the counter at most big supermarkets and pharmacies. Do you have the methyl folate instead of regular folate also for the MTHFR? xx

[FrancyItaly in reply to Chel91]

Ok I will get the one I find, probably I won’t find the 100mg but the one you mentioned should be fine. I am switching to Meth folate now, running to Holland and Barrett. Any particular dosage?

[Cinderella5]

I have the same gene and took at on day 1 on my FET cycles. I was also on 5mg of folic acid instead of the normal dose. xx

[FrancyItaly in reply to Cinderella5]

I started medications on Tuesday and transfer should be on 15th-16th if all looking good at the scan on Monday. I shall start aspirin today! I am switching to Methyl folate but thank you! x

[Cinderella5 in reply to FrancyItaly]

Good luck.xx

[Hidden]

My clinic were on the fence (in Spain) however at my first health visitor meeting in UK, I was advised to take it. I was 8 weeks pregnant by then. I started taking it 2 months prior to transfer. X

[FrancyItaly in reply to Hidden]

Thank you for sharing, I have started it yesterday! x

[Hidden in reply to FrancyItaly]

Wishing you all the very best x

[MamaWeez]

Hello Francy! I am MTFHR homo not hetro but I started taking aspirin and clexane 5 days before transfer. It is risky to take aspirin before egg retrieval as it could make you bleed during the procedure. Doctor made me stop at least 48h before the retrieval. I stopped clexane at 6 weeks and kept taking aspirin throughout pregnancy

[FrancyItaly in reply to MamaWeez]

Both doctors here and in Italy say I don’t need heparin. I don’t have to do egg collection just a FET in around 10 days if all goes well. I started aspirin yesterday, only 75mg. This is the only dose they sell here in the UK right? x

[MamaWeez in reply to FrancyItaly]

To be honest, my hematologist said I do not need it as well but my fertility expert recommended and I was desperate due yo previous miscarriages. I bled heavily around 5 or 6 weeks pregnant and stopped clexane. Pregnancy progresses with only aspirin 100 which was recommended by my hematologist so I believe you are on the right track. I live in Dubai and not in UK anymore, so not sure what dose they sell in UK anymore.

Also, keep in mind that I have both gene mutation and you have one, so my case is more ‘severe’. My cousin is hetro as well and her pregnancy progressed without clexane or aspirin (she is allergic). Wishing you all the best in your FET xxxx

[FrancyItaly in reply to MamaWeez]

Sorry to hear about your miscarriages. Here they sell 75mg, I asked my doctor in Italy if I should take one and an half and she said 75mg ie even better so I am sticking to that. Thank you so much and wishing you the best for 2022 x

[MofM]

My Greek clinic wanted me to start low dose aspirin 5 days before embryo transfer (with the progesterone), my British one on the day after (but I was already on Clexane, due to coagulation issues). The dose is 75mg.

I am also on 5mg of folic acid, which I have been told is the standard if you have mutations on the MTHFR gene -- and which is also quite standard in Italy. Btw, if you can source it in Italy it will be much cheaper!

[FrancyItaly in reply to MofM]

Thank you so much, tbh medicines are more expensive in Italy! But anyway, the cost is ok, I just want to make sure I do the right things this time! Thank you for your help x

[MofM in reply to FrancyItaly]

I am not sure regarding all medications, but I paid 10€ for 120 pills of 5mg folic acid while here is 5£ for 28 (with Pharmasure). Also, Lentogest is 3.85€ or 25£. But low dose aspirin is cheap everywhere!

Fingers crossed for you! xxx

[Eternalwarrior]

Hello lovely,I have had 5 miscarriages and I am now pregnant for the 6th time and on 150mg aspirin, as advised by the NHS Rainbow Clinic. I started the day of my BFP. I have blood clotting problems and I am also on heparin. Have you seen a haematologist? Wishing you lots of luck! xx

[FrancyItaly in reply to Eternalwarrior]

No I have not but I have had all tests and do not need heparin apparently. If I get my BFP I will go to my private clinic and I’m sure they will monitor me well! Thank you! x