When is it our turn?? Failed DE cycle.

[Hopeful80]

Hello all

Firstly I dont post that often on here but without this forum I would be so lost.

Today I got a BFN on our first DE cycle. This is our 5 th cycle/ 3 rd transfer- first with DE. I was told I had a 5% chance with my OE about 2 years ago but when you are told you have a 57% chance with DE you have to wonder will our day ever come like so many more of you fabulous ladies on this forum!!

Our Donor had 11 eggs collected and 9 fertilised. We only got one to day 5 blastocyst which was transfered and we have a 6 day blastocyst in the freezer( I dont know the grades).- i did ask!! If a day 5 didn't work I'd wonder about a day 6.

I just dont know what to do next- the 2 ww I had symptoms which I did not have before and I really thought it had worked. I know we all symptom spot but honestly progesterone is like some evil drug that gives you false hope!

Should my OH sperm get DNA fragment tested? My lining was 11mm on day of transfer.my donor was a proven donor. What tests if any should I do?the day after transfer I got some hot flushes was this my body rejecting it?

I'm sorry this post is so long. I just feel so sad and angry too. I'm a positive person and I have always had a "our day will come attitude" but it is v hard right now to believe that will happen,? I hope whoever I murdered in a past life was worth if for this hand we have been dealt with).

I always get hope from birth announcements on this forum and positive stories but right I just dont know anymore xx

[User20]

Hi Hopeful,I'm so sorry to hear your transfer has failed. I totally know how you feel. I found out yesterday that our transfer (2nd with DE) has failed. It's so sh.... isn't it! Sending you big hugs 🤗 xxx

[Hopeful80 in reply to User20]

Thank you so much and big hugs back to you too.It is total crap - I'm so sorry your ttansfer also failed it never gets easier

Did you do any extra tests etc between the first and second round of DE?

[User20 in reply to Hopeful80]

I didn't do any other tests, but they increased my progesterone. I'm having my follow up appointment next week, let's see what they say...

[Hopeful80 in reply to User20]

Thank you - I'm attending a clinic abroad so I will do up a list of questions.

[IVFat40]

I'm so so sorry this has happened. There are no words really, it's just so unfair.

[Hopeful80]

Thank you - I hope you are doing well and sending you good wishes

[Marisa32]

Sorry it didn't work out. I would put the 6 day blast in next and if nothing, then definitely look into DNA fragmentation test.

[Hopeful80 in reply to Marisa32]

Thank you Marisa -

[XOXO13]

So sorry your transfer was unsuccessful … sending big hugs ♥️

You said only one of your eggs made it to D5 blastocysts (another to D6), when did the others stop developing? I think it’s if from D3, then it’s likely a sperm issue - maybe ask that question.

I’ve had four transfers in total, and with each unsuccessful one, we tried something new. What tests have you explored? I’ve explored Hysteroscopy, HyCoSy, karyotype screening, tested for blood clotting issues (which I have) and recurrent miscarriage blood tests. My husband had sperm analysis and DNA fragmentation tests. We then moved clinics and explored immunology and I think this was our key to unlocking the right protocol for us because with our fourth transfer, my embryos stuck. The reason we did this was because I felt like I was getting poorly with each transfer (fever, swollen glands, run down and generally like my body was rejecting the embryos. This isn’t supported by science but more my gut).

Could you discuss some of these options with your doctor and see what you could do differently next time?

Sending you lots of hope and luck 🍀 xxx

[Hopeful80 in reply to XOXO13]

HelloThank you so much for the long detailed response.My clinic is abroad so I'm putting a list of questions together to send them. 'm hoping they can tell me at what stage D3-D5 did things slow down etc.

My OH sperm analysis was always ok but we are now thinking DNA fragmentation needs to be looked at too.

I have only had a laproscopy and dye test which came back fine. I have v low AMH so that's why we had to move to DE. My progersterine is always ok. I'm going to look at immune testing now too and will see what my clinic advises.

They had me on clexine which would help if I had any clotting. I'm now thinking should I be on steroids too!!

Sending you luck too thank you xx

[XOXO13 in reply to Hopeful80]

On my fourth round I took steroids (dexamethasone) daily from stim phase and had intrapilids one week before transfer and another when I was about 5 weeks pregnant. I continued steroids until I was about 13 weeks pregnant. I also took clexane and aspirin daily from stim phase and I’m taking them until I’m 34 weeks. My progesterone is also usually okay but they added in POI shots every day until I was twelve weeks and I continue taking pessaries until I’m 24 weeks. On top of that, I also increased my stims dose (as I have lower end AMH for my age) and was closely monitored for any changes. I think all of this made a difference to the success of my fourth round - so keep pushing and ask all of those questions. Everything crossed xx

[Hopeful80 in reply to XOXO13]

Thank you so much I will definitely ask all those questions. When I did ivf with my OE I was on the highest dose of stims but my embryos were never great quality. Congrats to you on your pregnancy wishing you the best of luck. Xx

[ChloeDE]

Sorry to hear you are going through this.

We did a donor round last year with a proven donor. We got 2x blastocysts and transferred both. One stuck but miscarried.

We did another round with a different donor and got 3x blastocysts. We have twins now and one frozen.

My partner's sperm isn't great. We didn't do DNA fragmentation testing but the clinic used MACS to help select the best sperm. I believe they use this for fragmentation issues. It might be worth asking about. Hopefully you don't need it though and your frostie is the one. X

[Hopeful80 in reply to ChloeDE]

Hello Chloe

Thank you so much for replying. I'm sorry you had to go through a miscarriage last year. Our donor was a proven donor too and only 28 so I had foolishly thought ' this will work" I hope the clinic can advise me on some changes if any before I transfer the frostie.

I will definitely enquire about MACs - I'm already thinking of one more go with DE if the frostie doesn't work as financially its getting goo much now.

Congrats on your twins that is the best news I'm sure you are kept busy.

Xxx

[ChloeDE in reply to Hopeful80]

We added Prednisone and clexane for me during the second round too. I didn't do any testing but took them as a precaution. I was told they wouldn't do any harm.

Good luck. X

[Hopeful80 in reply to ChloeDE]

Thank you Chloe xx

[FertileMind]

Sorry to hear about your disappointment...that's so hard.

Have you looked into LIT therapy? I'm wondering if this might be needed in my case too, as I can't seem to implant.

"Lymphocyte Immunization Therapy or LIT is a procedure whereby white blood cells from the prospective father are injected into the skin of the prospective mother to prepare the maternal immune system for pregnancy. Because pregnancy tissues are the product of both the mothers as well as the fathers genes, LIT assists the mothers immune system in the development of immunologic tolerance to the genetically foreign pregnancy tissues."

I'd be interested to hear what your clinic says in your follow up appointment about next steps for you. Keep the faith hun...

[Hopeful80 in reply to FertileMind]

Hello Thank you for replying to me. I have not heard about LIT . I will ask my clinic

I foolishly thought with a DE from a proven donor it would work.

I read with a DE failure it is either the embryo, the lining ( mine was 11m day of transfer) or immune issues.

I will email my clinic with a list of questions tomorrow and also to see if any other drug options should be added before I transfer the frostie.

I will let you know what they say.

Hanging in there xx