Reducing Menopur to get better quality eggs?

[IVFat40]

Hello lovely ladies, I'm hoping to pick your collective brains again.

I'm 41. In my last cycle 7 months ago I was on 300iu Menopur and got 18 eggs, 6 good blastocysts (2 BFN, 1 chemical, 3 still frozen).

I'm just starting a new fresh round and my Dr has recommended reducing my Menopur to 225 iu, with the aim of getting less eggs but better quality eggs.

I was a bit surprised as for me/given my age etc. I felt like 6 good blasts last time was a good outcome, plus I'm now 7 months older so might respond slower. But, of course I'm not a Dr and don't want to ignore her advice.

Has anyone had experience of decreasing their Menopur dose, and did you see a change in egg quality?

Thank you!

[Orla9298]

I got better quality definitely from lower doses, my best round was on only 150iu xx

[IVFat40 in reply to Orla9298]

Thank you!

[BBHH1]

Looks like you had a good cycle and should continue. Make sure you se taking CoQ10 and DHEA probably good fit you. Good luck!

[IVFat40 in reply to BBHH1]

Thank you, I did decide to go that way in the end, stuck with my previous dose of 300, so hard to know what's best but fingers crossed. And thank you too I'm on CoQ10 and DHEA (actually I feel they really helped my last round)

[BBHH1 in reply to IVFat40]

But if that cycle does not work I would try decreasing menopur. I actually take 150UI a day. I understand that is because older woman have premature luteinization and too much LH (that menopur has) can be a bad environment and decrease quality.

Also I think it’s important to trigger slightly earlier, when leading follicle 16-18mm (called early retrieval) Best

[IVFat40 in reply to BBHH1]

Thank you hun. I ended up with 4 frozen blastocysts last cycle, with my age and everything I felt happy with that. Only 8 eggs (which is my lowest amount yet), but it felt like a good conversion rate to blastocyst.

I've actually decided to bank those and am about to start my next egg collection (which will be my 5th and last). Thinking I'll stick with the same does of menopur again, but it's still hard to know.

[BBHH1 in reply to IVFat40]

I agree with you. Good results as far as numbers and probably should not change. The only concern is that you can’t know about the quality until you try some... but banking makes sense since you are producing

[IVFat40 in reply to BBHH1]

Thank you 😊

[Hidden]

My first round was 150 units got 8 eggs 2 blasts. 1 chemical one mmc at 6-8 weeks

Second round After 8 months i was on 225 units and got 18 eggs BUT only 9 were useful for icsi and again 2 blasts. Again a chemical so far.

So i start to think my body doest necessary like higher dose BUT you had 6 blasts so chances are you going to have a good outcome again x x x x

[IVFat40 in reply to Hidden]

Thank you hun, our bodies are so hard to predict aren't they. Good luck with your next blast, here's hoping he/she is the one. Sounds like your body does a really good job with implantation, so when that genetically perfect embryo arrives you'll be flying (not that I mean to down play miscarriage and chemicals, I know from my own experience chemicals are so upsetting, and I can only imagine miscarriage is even more painful).

[Hidden in reply to IVFat40]

I know what u mean love 🥰thank u and good luck 💐🤞💐

[try2020]

Hi! can I ask if you have considered pgt-a testing your embryos? good luck with you current cycle 🤞🧡

[IVFat40]

Thank you!

Such a good question at my age. I think for me I've decided I would rather give all my blastocyst embryos a chance and see what happens. Of course that does mean the pain of transferring embryos that aren't genetically viable and so don't succeed, but for me I worry about PGT not being 100% reliable and the possibility (even if small) of discarding an embryo that might have gone on to be a healthy baby. Is it something you've tried/are considering yourself?