Progesterone pessaries for miscarriage?

[Mama196]

Has anyone taken Cyclogest (progesterone) pessaries after multiple miscarriages? I’ve had two in the last year, one missed at 13 weeks (medical management- foetus 8 weeks gestation) and one at 8 weeks (no fetal pole visible only gestational sac). I’m not eligible for tests on NHS as you need to have had three miscarriages for that but I paid to see a private specialist who said I could take them but there was no evidence it would help. I’ve read studies that said the same about no evidence.

She prescribed them for 8 weeks from positive pregnancy test (yesterday) to 12 weeks.

What dose have people been prescribed?

I’m now nervous about taking them in case they could do more harm than good!

[Fingerscrossed38]

So sorry for your losses.

I have taken them for a year but they aren't enough for me. I also did combined 3x Lubion (progesterone injections) + 4 x cyclogest daily which is a high amount of progesterone and still didn't get me over my clinics threshold of 100. So since Monday I've been on prontogest progesterone in oil injections which hurt as they're intramuscular! But that alongside 3 x cyclogest a day is gotten my progesterone to 173.

I'm not sure of your age or finances but there are so many tests you could do. You may have a blood clotting issue, the embryos may have had chromosomal abnormalities, it's hard to know. You can try again and just supplement progesterone after you're sure you've ovulated each month but be sure to get a progesterone blood test to check your levels and if that doesn't work you may have to pay privately for more extensive testing... Best of luck.🍀

[Mama196 in reply to Fingerscrossed38]

Thank you. I’ve had a bit of testing but not chromosomal- as I already have a son the specialist reckoned that was less likely to be a problem. She just thought they were random to be honest but agreed to prescribe progesterone for my own piece of mind- she doesn’t think there’s any evidence for it.

[Mama196 in reply to Mama196]

I should add - no evidence for natural conceived pregnancy- lots I believe for IVF as that seems standard to maintain an IVF pregnancy.

[Fingerscrossed38 in reply to Mama196]

Apparently you can't have too much progesterone so there's no harm in touching it a whirl. Good luck with it all xx

[Mama196 in reply to Fingerscrossed38]

Thank you. Did you take baby aspirin as well? I’ve been reading that a lot of people do and am unclear if it’s because the progesterone itself can increase risk of clots or just because the previous miscarriages mean a risk of clots. I’ve not been prescribed it. I’m a bit worried about this clotting issue and terrv

[DianeArnold Partner Nurse Fertility Network UK]

Hi Mama. Often extra progesterone is prescribed following a miscarriage for your next transfer. Speak about perhaps trying a low dose aspirin or heparin to ensure good blood flow and help to prevent clot formation - worth asking to see what your specialist feels. A blood test to check out both your chromosomes, just in case there should be a problem there. Just a few ideas, but I do wish you well when you try again, and of course for success. Diane

[Mama196 in reply to DianeArnold]

Thanks for your reply- does progesterone increase risk of blood clots? I’m was worried as the leaflet implies it does and I have the MTHFR mutation which some think can increase risk of clots.

Specialist was against using aspirin and heparin initially as she thinks miscarriages were random and says they carry risks themselves so she’d only recommend if I had a 3rd miscarriage.

[DianeArnold Partner Nurse Fertility Network UK in reply to Mama196]

Hi Mama. I think that I would be more inclined to go for the progesterone to help sustain the womb lining. There is an enzyme called serrapeptase that some women use instead of aspirin/heparin, as it reduces inflammation, so possibly works towards reducing the chance of clot formation. Speak to your specialist and see whether he/she feels you would benefit from its use. Diane

[Hidden]

Hi Hun.

Firstly so sorry to hear of your losses.

Congrats on your BFP hope this is your rainbow baby 👶🏻

Anyways I was prescribed progesterone pessaries to take from a positive test till 12 weeks. I became pregnant with my daughter a year after a CP. ( I fell naturally after my third surgery to treat endo. )I believe the progesterone helped keep my little girl safe ( I had bleeding between 6-14 weeks very stressful) she’s a perfectly healthy 6 month old baby it did her no harm.

All the best with your pregnancy xxx