I don't know what to do! : Hey all. I... - Fertility Network UK

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I don't know what to do!

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Hey all. I need some words of advice and encouragement. I am 32 with PCOS and currently going through NHS ivf treatment. I am on the menopur injections and started on 125mg a week ago and the dose has now been raised to 300mg as my follicles are not big enough. Basically I am not even reacting to the medication. After this weekends scan I have been advised that if I am still not reacting I have to start the process again. I just feel so disappointed. I don't know what I am doing wrong. Someone please advice anything I can possibly do to increase my chances. Please help!!!!!

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I haven't started my IVF yet but I have read on this site that someone had to start again and responded better. You need to get out of the frame of mind that it's your fault lovely. Unfortunately our bodies react differently to medication. Keep focused on your goal of being a mum and that this is another bump in the road. Good luck xxx

Thank you xxx

It's defiantly not your fault and unfortunately there's nothing you can do to make your body respond. I know it will be very disappointing to stop but it will give your consultant time to come up with another plan to improve your chances. I needed extra days injecting, they don't know how we'll respond to the drugs.

Good luck.

in reply to pm27

Thank you. Xx

I was on Gonal F 150 first time round and basically didn't respond at all. My oestrogen only reached 150. I was absolutely gutted because hadn't even considered how difficult it was to even get to egg collection.

I had to wait for my period and then started again, this time on 300. I had a crazy response (my oestrogen was 20,000). I got 8 eggs last Monday and 4 have fertilised. This time I'm doing a freeze all cos they are worried about hyperstimulation and my progesterone is too high (another thing I didn't know was a factor).

There is nothing you can do to change it and its just part of the IVF rollercoaster. It doesn't mean you won't respond in the future and be successful.

Good luck.


I have severe PCOS too and was resistant to clomifene and similar drugs. As luck would have it I was not resistant to gonal f, which they have used in my IVF treatment at my clinic. I don't know if it's a different drug to menopur but maybe you can try gonal f of you're resistant to menopur? I'm not sure how NHS cycles work as we don't have them near where I live. Good luck!

I'm 31 with PCOS and am on the short protocol as I have unreliable periods. I was on 112.5 of Gonal F last cycle which they upped twice to 150 throughout my stims phase in cycle 1 and it took right up to the 15th day of stimming to be told we could proceed to EC as I didn't react quickly to the drugs. We ended up with 9 eggs. Unfortunately after having 1 healthy blastocyst transferred we had a BFP and it just didn't work for us. I'm now on Cycle 2 with a higher starting dose of Gonal F (150) and I have lots more follicles at this stage than in cycle 1. Is this your first round? I'm told that the first round is really like a trial run as they're testing what dose will work and which drugs are best for your body. If they abandon the cycle they are doing it for good reason, and if it's before EC it means you don't lose a cycle and will get another shot at it. So another way of looking at it is that you're having a 'trial run' without losing a cycle... so next time they will know more about the drugs and dose you need and fingers crossed you'll be reacting more. I know it's disappointing but you wouldn't want to look back with hindsight and wish you'd not gone through to EC on that round if it meant you didn't get any eggs or very few. It's easier said than done but try to have faith in the doc's opinions and know that it really shouldn't take much longer in the grand scheme of things (if your periods are regular it could be as little as 4 weeks delayed). Chin up lovely xx

Thank you all for sharing your experiences and kind words. It really does help boast my confidence. It is my first cycle and everything else was fine until I started the injections. My stats were good and the doctors were impressed which gave me confidence and made me relaxed. So when I found out I wasn't responding to the medication it was a big knock back. I will take your advice and try and stay positive and be patient because I believe I will eventually get there. Thanks again and have a lovely day. Xx

And above everything don't blame yourself.... our bodies all work in mysterious ways!! The docs will find the right dose for you and everything will be perfect in the end xx wishing you lots of luck πŸ€πŸ€πŸ€

Thank you. Wishing you the best too. Xx

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