Recurrent miscarriages - investigations and treatments

[Koalah]

Hi all,

I have had 4 miscarriages in a row since January 2020 trying for baby N1.

I have been referred to recurrent miscarriage clinic after 3. Done all the test possible. Blood tests, etc. Everything came back normal. Husband’s too on private. Genetics analysis on 2 babies came back normal.

I have recently seen a private recurrent miscarriage specialist in London who had done more blood tests (all normal too) and is now suggesting a hysteroscopy. Even though I had the womb checked many times and especially twice during investigations (3D), this well known professor suggests to do a thorough examination in case there is an unspotted issue with the shape of the uterus.

Has anyone done it?

The professor suggests to try again and not take any medicine for next pregnancy.

Also, I have self referred myself to a clinic in Coventry to check natural killers cells. 1st biopsy came back normal, I did the 2nd one recently but high chance that this will also be normal.

The professor at that clinic thinks, since all my miscarriages are missed ones and happening around 6-7 weeks, that I will benefit on taking prednisolone (steroids) along with progesterone and maybe aspirin. Last 2 pregnancies I did take progesterone and aspirin, and I know there is little evidence they these can help but I more interested here in any experience around steroids.

His thought is that maybe my endometrium is enflamed or getting inflamed when pregnant and steroids could help.

Has anyone been using steroids for recurrent miscarriages?

Do you have an opinion on these 2 different views?

> trying again (5th time) with no medication help

> use steroids on next pregnancy

Also do you think thee is any benefit on doing an hysteroscopy?

Littles research in this area means that even the top specialist in recurrent miscarriages disagree in the unproven causes and treatments which make things more challenging.

Thank you for your help,

[Paris1771]

Hi Dear!Sorry to hear u had such a tough time!

I had MC as well and I had blood test that showed I had slightly high immune problem(NK cells) and I hav Prednisolone 10mg on my last cycle up to week12. I had also blood thinner injections Fragmin 5000unit and aspirin during the whole pregnancy! I think Prednisolone was absolutely neccessary for me and I would reccomend u the second option , using steroid!

My fingers are crossed for u! Wish u all the luck!

[Mugsy5]

I had a hysteroscopy and laperoscopy yesterday. (I’ve also had 4 miscarriages since January 2020- so sorry for your losses) she found endometriosis on my ovaries during the lap and a build up of tissues that could be inhibiting implantation in my uterus via the hysteroscopy. I also had several ultrasound and that spot hadn’t shown up on them so I was glad I did both procedures. I had never had painful periods but I had hip pain and left quadrant pain that I believe was the endometriosis all these years. Hope that helps and hope baby number 5 goes well for both of us!