I recently received 4 months worth of decapeptyl injections. I had two extremely heavy periods on them but the consultant advised they would stop after the 3rd injection. I still had another bleed. The biggest side affect however has been depression, I am not sure whether it is to do with these injections but since going on them I have entered the worst depression of my life. I have never been so miserable. I have been off of the injections now for around 10 weeks but still cannot get out of this slump. I am just wondering if anyone else has experienced mood changes or depression on Decapeptyl? Does it last? Is this depression a forever thing now? I am now waiting to see the endometriosis clinic as the gynecology consultant referred me to them last October, I called chasing the appointment as I thought I would of had if on the injections but they informed me it's still up to another 18 month wait! I feel deflated.
Decapeptyl & depression : I recently... - Endometriosis UK
Decapeptyl & depression
morning - I was on decepeptyl for 7 months and decided to come off of it. The more I got the injections, the worse I felt. Both physically and mentally.
The only way I can describe my mind was, it was like a big black hole and some days it felt like my world was going to end. The injections are horrendous (for me anyway)! Gave me more symptoms!
After around 6 months I felt much better, it must take time to get out the body?
X
I really do hope I start to feel better, I have never felt depression like it. I have a 1 year old and it's making being a Mother so hard because I am always so unmotivated and down. I wish I knew that depression was one of the side affects as I wouldn't have had them if I had known. I just feel so much sadness, struggle to even smile. I have been back to the GP and they want to put me on all sorts of anti depressants but I refuse, I am beginning not to trust any medication anymore.
Have you been put on anything else instead?
I was put on HRT when I started decepeptyl as the hot flushes and sweats night and day were horrendous. I just couldn’t function. I am still on HRT now and it does help me. Still trying to loose the weight I put on with decepeptyl. It makes you very thick round the stomach and my boobs were so hard and big, if I knew all of this before my gynaecologist put me on it I would have refused it x
I am glad you mentioned that actually because I have felt bigger round the belly since the injections. I am just so fed up. I feel sorry for my son because he is having to deal with me like this 
how you feel will get better - I know it won’t seem like it now. X
Hi, I’m really sorry to hear that you are feeling like this, feeling depressed is draining and can make us feel helpless. I understand you feel dubious about medication - especially at the moment - but as someone who has experience depression myself while having young children (I had post natal depression) the tablets really did help me to get back on an even keel. Please go back to your GP if you are struggling because they can help you. It feels like it will last forever, but it won’t and you will feel better. Re decepeptyl, I’m on 4th injection and it has definitely impacted my mood - all hormonal treatments do with me. I have gained weight also.
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