Help! Pain relief advice needed! - Endometriosis UK

Endometriosis UK

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Help! Pain relief advice needed!


Hello ladies.

So long story cut short, had Endo and had it removed 1 and half years ago, been diagnosed with adenomyosis now. Lots of lovely pain, had zoladex but now off it and just dealing with it with mefanamic acid and Amytriptyline.

So the big question is, does anyone take cbd oil with Amytriptyline? I'm desperate to try anything, I'm even trying (but failing) to do the endo diet to get some relief. I want to try cbd but know that it can have a negative effect. I only take it at night and wondered if I took the cbd during the day, it might help.

Any advice would be great. Xx

5 Replies

Morning lovely, i hope you are okay today. Does the cbd help ease the pain at night? I think if it is then maybe take some in the morning and see how you feel. It's worth a try and if it doesn't help then go back to your gp to talk about different pain relief. 💛

Morning. Today is not too bad. But I haven't started taking it yet. I'm just curious if others have tried it. But also if they take it with something like Amytriptyline. I may speak to a pharmacist or something to get some advice.

Your GP might not know much about cbd. But there are drug-nutrient-herb interaction databases you can check online. A word of caution, if no interaction is listed that doesn't necessarily mean it's safe, it might mean there just isnt any research in that area. I checked 2 databases, one said no known interactions, the other said as follows:

Interactions between your drugs

Moderate: amitriptyline cannabidiol

Applies to: amitriptyline, cannabidiol

Using amitriptyline together with cannabidiol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.


Thank you. I did find some stuff like that but still wondered about it.

It's worth mentioning to your GP that you are planning to try it, just so they know. Maybe just start with a low dose and see how it affects you, and gradually build up. But hopefully someone else here will have tried it and can give you their personal experience :)

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