After a meal the blood sugar rises . To counteract this and to make sugar available to the body, specialised cells in the pancreas get activated to secrete insulin. In people with diabetes, this mechanism fails, which leads to elevated blood sugar and a host of other diabetes related complications.
The cellular signal for insulin secretion is an influx of calcium which triggers the release of small hormone containing vesicles. Recent research works indicate that a tiny change in the cells architecture is at the heart of secretion defect.
Using high resolution microscopy, the research group found that calcium normally enters right next to storage vesicles to trigger insulin release. In type 2 diabetes the channel proteins that allow calcium the entry are instead located too far away from insulin vesicles which cause secretion to fail. The findings after a first glimpse at the intricate relationship between insulin secretion machinery and calcium channels suggests that drugs aimed at at their interaction could be developed to treat diabetes .
Look at all Indian philosophy....most of books are written in question and answer form...even 'the very famous 'Charak Sanhita' the great knowledge book of Ayurveda is also written in question and answer form...
Question and answer form is the only form used by ancient Indians to explain the things...that is the way we should reach to truth...
Are u feeling offended??? they are not that tricky questions?? are they??
I thought you would answer the questions happily for the benefit of members...
well sure information is always needed..however it is also expected further discussion on same...
world is full of information...google is always there to help all of us... but just passing information may not be very useful...discussion will help all of us to understand and digest information.
now are we diverting again from main post???
let us discuss more related to post...
then why do we see hyperinsulinemia in newly diagnosed D2 patients???
And particularly for this thread....is it due to disturbance of calcium channels???
That's is indirect relationship 😊😊. D leads to arterial wall edema. Reduced compliance and so high bp. Insulin has nothing to do with bp directly. T1d taking insulin if controls D would have positive effect on bp.
These people are getting lots of funds for just coining such weird theories. Ca influx results in secretion of many hormones. Why should insulin secretion be adversely affected selectively 🐒🐒🐒🐒
So called researchers are puppets and slaves to the money given to them by drug companies.
Sglut2 inhibitor concept is idiotic and criminal. You add to what kidneys are doing. Damage to the K and potentially hazardous presence of glucose in urine. More prone to Urinary infections and presence of sugar in urine hinders the cure. Spread to blood causing lethal septicemia may occur and in such condition sglut2 I add fuel to the fire.
I'd certainly take doctors prescribing such drugs to the criminal court apart from consumer court if something wrong happens. Criminal negligence.
With the menopausal events the endothelial lining becomes thin and more susceptible to insults. If infection occurs, uti esp it is very difficult to eradicate with antibiotics only. Such females need to be given hrt. As such also antibiotics never cure infection if our defence system is weak. Antibiotics weaken the microorganisms which then can easily be removed by white cells and other defence mechanisms. If sugar is present in urine and body it works as tonic and the source of energy for microorganisms.
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